The present invention provides an organic bioelectronic HD device system for the effective removal of protein-bound substances, comprising PEDOT:PSS, a multiwall carbon nanotube, polyethylene oxide (PEO), and (3-glycidyloxypropyl)trimethoxysilane (GOPS). The composite nanofiber platform exhibited (i) long-term water-resistance; (ii) high adhesion strength on the PES membrane; (iii) enhanced electrical properties; and (iv) good anticoagulant ability and negligible hemolysis of red blood cells, suggesting great suitability for use in developing next-generation bioelectronic medicines for HD.

A system is disclosed for the automated collection of dialysis and physiological data. An example system includes a dialysis machine configured to generate dialysis data and a wireless peripheral device configured to generate physiological data. The system also includes a personal digital device including an application configured to communicatively couple to the dialysis machine. The application is further configured to detect being within a wireless range of the wireless peripheral device, pair with the wireless peripheral device, receive the physiological data from the wireless peripheral device, and transmit the received physiological data to the dialysis machine. The dialysis machine is configured to store the received physiological data in conjunction with the dialysis data.

A system is disclosed for the automated collection of dialysis and physiological data. An example system includes a dialysis machine configured to generate dialysis data and a wireless peripheral device configured to generate physiological data. The system also includes a personal digital device including an application configured to communicatively couple to the dialysis machine. The application is further configured to detect being within a wireless range of the wireless peripheral device, pair with the wireless peripheral device, receive the physiological data from the wireless peripheral device, and transmit the received physiological data to the dialysis machine. The dialysis machine is configured to store the received physiological data in conjunction with the dialysis data.

A device for extracorporeal blood treatment, in particular a dialysis device, including an internal fluidic system for a treatment liquid, in particular for a dialysis liquid, the internal fluidic system having at least two liquid connectors for connecting a substantially cylindrical filter element, in particular a dialyzer, to the internal fluidic system for passing a treatment liquid through the filter element, and including a mounting for exchangeably holding the filter element in such a way that the filter element can be connected to the liquid connectors of the internal fluidic system and to an extracorporeal blood line in an intended manner, wherein the mounting for holding the filter element is designed in such a way that a cylinder longitudinal axis of the filter element is substantially horizontally aligned.

A device for extracorporeal blood treatment, in particular a dialysis device, including an internal fluidic system for a treatment liquid, in particular for a dialysis liquid, the internal fluidic system having at least two liquid connectors for connecting a substantially cylindrical filter element, in particular a dialyzer, to the internal fluidic system for passing a treatment liquid through the filter element, and including a mounting for exchangeably holding the filter element in such a way that the filter element can be connected to the liquid connectors of the internal fluidic system and to an extracorporeal blood line in an intended manner, wherein the mounting for holding the filter element is designed in such a way that a cylinder longitudinal axis of the filter element is substantially horizontally aligned.

Methods and systems for quantifying blood brain barrier (BBB) permeation of glycosylated peptides. The methods and systems feature microdialysis probes and mechanisms for infusing preservative agents into the outflow tubes of the microdialysis probes. The preservative agents help reduce unwanted degradation of the glycosylated peptides or other compounds, which can lead to a more accurate and complete analysis of the outflow tube perfusate.

Methods and systems for quantifying blood brain barrier (BBB) permeation of glycosylated peptides. The methods and systems feature microdialysis probes and mechanisms for infusing preservative agents into the outflow tubes of the microdialysis probes. The preservative agents help reduce unwanted degradation of the glycosylated peptides or other compounds, which can lead to a more accurate and complete analysis of the outflow tube perfusate.

The specification discloses a portable dialysis machine having a detachable controller unit and base unit. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The manifold includes diaphragms adapted to minimize the dead space between the dialysis machine pins and improve responsivity. The base unit has a planar surface for receiving a container of fluid, a scale integrated with the planar surface and a heater in thermal communication with the container. Embodiments of the disclosed portable dialysis system have improved structural and functional features, including improved modularity, ease of use, and safety features.

The specification discloses a portable dialysis machine having a detachable controller unit and base unit. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The manifold includes diaphragms adapted to minimize the dead space between the dialysis machine pins and improve responsivity. The base unit has a planar surface for receiving a container of fluid, a scale integrated with the planar surface and a heater in thermal communication with the container. Embodiments of the disclosed portable dialysis system have improved structural and functional features, including improved modularity, ease of use, and safety features.

A filter device (10) for filtration of fluids, in particular for the dialysis of blood. The filter device (10) comprises a housing (12) having a first end (14) and a second end (16) and defining a fluid chamber (18) extending between the first end (14) and the second end (16). The filter device (10) further comprises a first lid (20) provided at the first end (14) of the housing (12) and comprising a first fluid port (22), a first compartment (24), a second compartment (26) and a first internal separating wall (28) separating the first compartment (24) from the second compartment (26). The filter device (10) further comprises a second lid (30) provided at the second end (16) of the housing (12) and comprising a second fluid port (32), a third fluid port (33), a third compartment (34), a fourth compartment (36) and a second internal separating wall (38) separating the third compartment (34) from the fourth compartment (36). The filter device (10) further comprises a plurality of hollow fibers (40) arranged within the housing (12), wherein each of the plurality of hollow fibers (40) comprises a semi-permeable membrane and defines a fluid channel extending longitudinally through an interior of the respective hollow fiber (40). The filter device (10) further comprises a first sealing means (42) which separates the fluid chamber (18) from the first and the second compartment (24, 26), the first sealing means (42) having a first longitudinal end facing away from the second lid (30). The filter device (10) further comprises a second sealing means (46) which separates the fluid chamber (18) from the third and the fourth compartment (34, 36), the second sealing means (46) having a second longitudinal end facing away from the first lid (20). Still further, the filter device (10) comprises a fourth fluid port (50) and a fifth fluid port (52) both provided at the fluid chamber (18) and located between the first longitudinal end of the first sealing means (42) and the second longitudinal end of the second sealing means (46).