A module having polymeric gas-separation membranes is capable of operation in extreme temperature environments. In one embodiment, the module includes polymeric fiber membranes, a tubesheet for holding the membranes, and a sleeve encasing the membranes, all of which are made of materials having coefficients of thermal expansion which differ from each other by not more than about 10%. In another embodiment, the membranes, the tubesheet, and the sleeve are all made of materials having a glass transition temperature greater than a highest anticipated temperature of operation of the module. In another embodiment, the module includes a head, and a clamshell having multiple protrusions which engage corresponding grooves in the head and in at least two grooves formed in the tubesheet.

The present invention provides an intrinsically anti-microbial hollow fiber membrane for filtration of liquids. The membrane comprises a plurality of porous hollow bilayer membrane fibers wherein the liquid enters from outside of the fiber, passing through the porous membrane into the lumen of the fiber and coming out from the hollow ending of the fiber, wherein this configuration provides a liquid outside-in arrangement and retains the filtrate outside. It means that membrane of the invention has built in characteristics to act against microbes in order to provide the use with a safe liquid free from microbes. The outer side or outer wall of the hollow fibers may be configured to become hydrophobic whereas inner side or inner wall of the hollow fiber membrane may be configured to become hydrophilic to enhance the water permeability to a great extent. The hollow fiber membrane may be configured to give it an intrinsic anti-microbial capability. A device containing above said membrane has also been disclosed.

The present invention relates to high performance, crosslinked hollow-fibre membranes and a new process for manufacturing the same.

The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.

The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.

The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.

This forward-osmosis composite hollow fiber membrane module has hollow fiber bundles, wherein: the hollow fibers are each such that a separation active layer of a high-molecular polymer thin film is provided on the inner surface of a macroporous hollow fiber support film formed from a high-molecular polymer including polyketone; the film surface area of the hollow fiber bundles is 100 cm.sup.2 or greater; and the coefficient of variation of the average thickness of the separation active layer in the radial and thickness directions of the hollow fiber bundle is 0-60%, said coefficient being calculated through a method for measuring the mass of the separation active layer portion in a scanning electron microscope image in which a thickness-direction cross section of the separation active layer is imaged.

The present disclosure relates to bundles of hollow fiber membranes and a process for their production. The bundles are used for the manufacture of filtration and/or diffusion devices, e.g., capillary dialyzers.

A device for extracting biomolecules includes a membrane tube and a container. The membrane tube has an upper portion and a lower portion, wherein the upper portion has an open end and the lower portion contains permeable membranes and also has an open end. The container has an upper portion and a lower portion, wherein the upper portion has an open end, allowing the membrane tube to be pushed into the container and form a liquid-tight seal between the membrane tube and the container, and the lower portion has a closed end.

In a method for manufacturing an oxygenator, an intermediate spacer is disposed between a cylindrical heat exchange unit configured by winding a first hollow fiber membrane and a cylindrical gas exchange unit configured by winding a second hollow fiber membrane so that a first gap is formed between one end portions of the heat exchange unit and the gas exchange unit, and a first partition section of a first cover member is inserted into the first gap. In such an oxygenator, a first end portion of the intermediate spacer is located at a part that does not overlap the first partition section in a radial direction in the heat exchange unit and the gas exchange unit. The intermediate spacer is formed by winding an intermediate hollow fiber membrane.