A cartridge is provided for dialysis or other blood processing therapy. In the cartridge, fibers may be substantially uniformly distributed near a midplane, but near an end, in the inter fiber space, there may be void flow channels, which may cause fluid flow in the inter fiber space to transition within a short region to uniform flow with minimal stagnation zones. Void flow channels may be be radially oriented, introducing fluid from the outer circumference, or axially oriented, introducing fluid along the axial direction through passageways through the potting material. The fluid flow in the inter fiber space may be perpendicular to the fibers, or radial with respect to a cartridge longitudinal axis. The cartridge may have blood flow in the inter fiber space, and flow of dialysate or ultrafiltrate in the lumens of the fibers, or the opposite situation.

Disclosed are a hollow fiber membrane module, a filtration apparatus based on the same, and a method for manufacturing the filtration apparatus. The hollow fiber membrane module includes two headers respectively provided with a permeate collecting unit therein, wherein each of the headers has grooves on its two sides, the grooves being extended in a length direction of the hollow fiber membrane. Since one slide rod can simultaneously be inserted into grooves of two adjacent hollow fiber membrane modules, the hollow fiber membrane modules can mutually serve as guides for insertion/ejection thereof. Also, since the grooves formed on the header can serve as insertion holes into which a clamp is inserted, the clamp can be used for coupling between the hollow fiber membrane module and another element and reinforcement of the coupling.

A contactor system includes a plurality of contactor panels. Each contactor panel includes a frame member and a membrane array adapted to be received within the frame member. The membrane array defines a first end portion, a second end portion, and a plurality of hollow fibers. The contactor system also includes a first manifold in selective fluid communication with the first end portion of the membrane array of each contactor panel. The contactor system further includes a second manifold in direct fluid communication with the second end portion of the membrane array of each contactor panel. The contactor system includes a controller configured to provide selective fluid communication between the first manifold and the first end portion of the membrane array of each contactor panel.

The present invention relates to a gas exchange unit for use in extracorporeal membrane oxygenation (ECMO) or extracorporeal live support (ECLS) according to a method for producing such a gas exchange unit as well as a kit with a gas exchange unit and a humidifying and heating device.

A hollow fiber membrane module including a plurality of hollow fiber membranes, a case, in an accommodation interior of which the plurality of hollow fiber membranes are accommodated, the accommodation interior being open at both ends, and a pair of sealing and fixing portions that seal gaps among the plurality of hollow fiber membranes in a state where each of hollow interiors of the plurality of hollow fiber membranes is open on each of one end side and the other end side of the case, wherein the hollow fiber membrane module further including a holding member provided in the case and configured to hold the plurality of hollow fiber membranes, and the plurality of hollow fiber membranes are fixed to the holding member by the pair of sealing and fixing portions.