A method of operating a filtration unit of a filtration system includes feeding, during filtration, feed water containing suspended particulate material to an inside of each of a plurality of hollow fibres through a first inlet and a second inlet of each hollow fibre while simultaneously removing a filtrate from an outside of each of the hollow fibres through an outlet of a filtration elements. In addition, the method includes feeding, during back-washing, back-wash water to the outside of the hollow fibres through the outlet of the filtration element. Further the method includes discharging, in a first back-wash cycle, back-wash water containing entrained particulate material from the inside of the hollow fibres from one end thereof. Still further, the method includes discharging, in a second back-wash cycle, back-wash water containing entrained particulate material from the inside of the hollow fibres from the other end thereof.

Aspects of the present disclosure relate to filtration systems and methods for production of biologically-produced products, which may include pharmaceutical and/or protein products. Certain biomanufacturing systems described herein comprise a bioreactor (e.g., a perfusion bioreactor, a chemostat) and a filter probe comprising a filter bundle comprising a plurality of hollow fibers (e.g., longitudinally aligned hollow fibers). According to some embodiments, a center-to-center distance between any two hollow fibers within the fiber bundle at one or more points along a length of the fiber bundle is relatively large (e.g., greater than or equal to an average outer diameter of the hollow fibers of the fiber bundle, greater than or equal to 1.1 times a minimum diameter of the two hollow fibers). In some embodiments, the hollow fibers within the fiber bundle are arranged in an array (e.g., a hexagonal, linear, annular, or square array).

A hollow fiber membrane module includes a housing having an inlet formed one end thereof and an outlet formed on the other end thereof, in which hot and humid humidifying fluid flows in through the inlet and the humidifying fluid after humidifying a cool and dry fluid flowing out of the housing through the outlet; at least one hollow fiber membrane bundle which is inserted into the housing in the longitudinal direction; a partitioning part for supporting the hollow fiber membrane bundle and partitioning an inflow space, in which the humidifying fluid flowing into the housing momentarily remains, and an outflow space, in which the humidifying fluid momentarily remains before being discharged through the outlet; and a potting part for potting both ends of the hollow fiber membrane bundle to the housing.

Described is a gas exchanger with a restriction element or elements to reduce gas exchange as desired to avoid hypo-capnia and hyper-oxygenation in small patients. The gas exchanger includes a gas exchanger housing with an outer wall and a core which defines an inner wall and having a blood inlet for receiving a blood supply and a blood outlet. The gas exchanger also includes: a hollow fiber bundle disposed within the housing between the core and the outer wall; and a gas inlet compartment for receiving an oxygen supply and directing the oxygen supply to first ends of the hollow fiber bundle, wherein the gas inlet compartment includes at least one restriction element configured to allow the oxygen supply to reach only a portion of the hollow fiber bundle.

Disclosed are system and method for filtration capable of minimizing the energy consumption. The filtration system of the invention comprises a processing tank, a first pump for supplying a feed water to be treated to the processing tank, a filtering apparatus in the processing tank, and a second pump for providing the filtering apparatus with a negative pressure so that the filtering apparatus can treat the feed water to produce a permeate, wherein the processing tank is sealable so that the feed water in the processing tank can be pressurized by the first pump after the processing tank is filled with the feed water.

A hollow-fiber membrane module according to an embodiment of the present disclosure includes a rectangular tubular outer casing with at least one sidewall being open, the outer casing having a plurality of open ports, and an inner casing configured such that a plurality of hollow-fiber membranes aligned in a longitudinal direction of the outer casing are placeable in the inner casing and configured to be insertable into the one sidewall.

The disclosure relates to a container for filtering a suspension which comprises a lid and a vessel. The container comprises a filter that divides an interior space of the container into a first compartment and a second compartment. The lid comprises a first access and a second access. The first access is connected to the first compartment, and the second access is connected to the second compartment.

In order to efficiently transport a filtration target liquid to a separation membrane module and to facilitate additional simplification of equipment in a filtration device including the separation membrane modules in which a plurality of lines thereof are disposed in series, a filtration device according to the present invention is a filtration device including a plurality of separation membrane modules each of which separates a liquid to be filtrated into a permeated liquid and a non-permeated liquid, in which the filtration device includes: a series non-permeated liquid flow channel that forms a series unit by connecting non-permeation sides of the plurality of separation membrane modules in series; and a parallel permeated liquid flow channel that forms a parallel unit by connecting permeation sides of the plurality of separation membrane modules in parallel.

A filter module (10) including: a housing (12) extending between an opposing first (14) and second end (16) and defining an inner chamber (18), a plurality of hollow fiber membranes (20) located within the inner chamber, a tubesheet (26) including the ends (24) of the hollow fibers encased but open within a block of potting material, an end cap (30) secured to the end of the housing and including: a permeate fluid outlet (32) in fluid communication with the ends of the hollow fibers, and a concentrate fluid outlet (34) in fluid communication with the inner chamber, wherein the permeate and concentrate fluid outlets are axially aligned, and a concentrate distributor (36) including: an annular ring (38) located adjacent to the second end of the housing, at least one aperture (40) in fluid communication with the inner chamber, and an annular concentrate passageway (42) extending from the aperture and concentrically about the permeate tubesheet to the concentrate fluid outlet of the permeate end cap.

The present disclosure relates to capillary dialyzers for blood purification comprising from 85-95% crimped fibers and from 5-15% non-crimped fibers.