The invention relates to a filtration assembly (5) comprising an annular support (12) which comprises an annular step (13) having an apex on which a filter membrane (11) rests, and a cover (20) covering the annular support in order to hold a periphery of the membrane between the cover and the annular support. The cover comprises a ring (21) which fits around the step to trap the periphery of the membrane between the ring and the annular support, the ring being extended by a skirt (22) which extends as a projection from the ring to cover an external peripheral wall of the annular support and to exhibit an end face (23) which extends in continuity with a bearing face (24) of the annular support. The invention also relates to a removable cassette for an apparatus for sampling nanoparticles comprising such a filtration assembly.

A membrane gas-liquid contactor is arranged to define a fluid flow path for contact with a membrane in a manner to improve degassing efficiency. A degassing module housing the membrane is arranged with flow fields for distributing the fluid flow throughout the membrane contact area. The distributed fluid flow may have a uniform membrane contact opportunity.

A filtration filter is suitable for performing cross-flow filtration by using a metallic porous membrane. A metallic porous membrane has a membrane portion for filtering filtration objects contained in a fluid and a held portion provided at its outer periphery. A first frame member and a second frame member hold the held portion of the metallic porous membrane there between. The held portion has a bent portion bent to a second principal surface side opposing a first principal surface of the membrane portion. The first frame member is in contact with the held portion at the first principal surface side of the metallic porous membrane. The second frame member is disposed at an inner side portion of the first frame member and is in contact with the held portion at the second principal surface side of the metallic porous membrane.

A cell-capturing filter that filters out cells includes a metallic porous film having a plurality of through holes that extend through a first main surface and a second main surface, which are opposite to each other. The metallic porous film includes a filtering portion including the plurality of through holes, and a frame portion disposed to surround an outer periphery of the filtering portion. In the filtering portion, a first film thickness of the metallic porous film at a center of the filtering portion is smaller than a second film thickness of the metallic porous film at a portion located closer to the frame portion than the center of the filtering portion.

In a cell-capturing filter including a metal porous membrane, degradation over time is determined earlier. A cell-capturing filter includes a metal porous membrane having a plurality of through-holes that penetrate between two principal surfaces facing each other. The metal porous membrane is made of an alloy of nickel and an element selected from the group consisting of gold, platinum, and palladium, or a metal containing nickel as a main component. A metal containing copper as a main component is attached to a part of either one of the principal surfaces of the metal porous membrane. By checking a state change of the metal containing copper as a main component, degradation over time of the metal porous membrane can be determined earlier.

Provided herein is a membrane filter device comprising a cell top cover (A, Y) and a cell bottom cover (B, Z) covering the device, a flexible tube (35, E, F) whereas at the end of the tube, a nozzle jet (22) is also secured via conical reducer to produce upper Reynold's number and for distributing the feed fluid, within the hex hollow chamber (C, X) for storing and receiving feed fluid, a reducer chamber (C, R1, R2) for storing and receiving permeate filtrated fluid, a connector (32, 53, 56) connecting both feed chambers (A, Y, Z) and reducer chambers (A, Y, Z), a membrane assembly (M/F) comprising a layer of membrane (130) sandwiched by a pair of seal rings (P1, OR, P2) and a layer of support net (MS) for securing said membrane (M/F). Most of the joints are connected using threaded joint and flow pressure, therefore no external clamp, nuts or bolts is needed. The flexible tube and the cylindrical shape ensure uniform flow in chambers. The apparatus is therefore a user-friendly and steadfast membrane filter device.

A frit comprising a plurality of grooves; a drain hole; a transverse crossing lane; wherein said plurality of grooves are substantially parallel to one another and extend longitudinally across said frit; wherein said plurality of grooves comprise at least two different lengths; wherein said transverse crossing lane is substantially perpendicular to said plurality of grooves; wherein said drain hole is located within said transverse crossing lane; wherein said drain hole is located at a center of said transverse crossing lane.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

A catheter for intravascular use has a blood inlet and a blood outlet, and includes a membrane arranged in the catheter in such a way that at least one part of the blood flowing into the catheter via the blood inlet during operation comes into contact with the membrane. The membrane allows an exchange of at least one substance between a carrier medium and the blood. The carrier medium is a carrier fluid in which the substance to be exchanged can be dissolved, and the catheter includes a delivery device that is designed to at least partially compensate for a pressure difference between the blood inlet and the blood outlet during operation. A method for removing at least one substance from venous blood for diagnostic purposes uses a device of this type.

A new method is disclosed for extracting plasma from whole blood and metering the amount of plasma to an exact volume for dispensing into a diagnostic test, in a fully automatic and self-contained device. The device can be used in resource limited settings by unskilled users to facilitate sophisticated medical diagnostic testing outside of a hospital, clinic or laboratory.