The present invention provides a coated hollow fiber membrane which has an isoporous inner skin and a porous outer support membrane, i.e. an inside-out isoporous composite hollow fiber membrane, and to a method of preparing such membranes. The coated hollow fiber membrane is prepared by a method comprising providing a hollow fiber support membrane having a lumen surrounded by the support membrane, and coating and the inner surface thereof by first passing a polymer solution of at least one amphiphilic block copolymer in a suitable solvent through the lumen of the hollow fiber support membrane and along the inner surface thereof, thereafter pressing a core gas stream through the lumen of the coated hollow fiber mebrane, and thereafter passing a non-solvent (precipitant) through the lumen of the coated hollow fiber membrane. In order to remove the solvent or solvents completely, the membranes are kept in water for 1-2 days and washed prior to use. In order to maintain the porosity of support membrane, membrane pretreatment is advantageous prior to coating which reduces the infiltration of block copolymer solution. The membranes are useful infiltration modules, in particular microfiltration modules, ultrafiltration modules, nano-filtration modules.

The present invention addresses the problem of providing: a composite hollow-fiber membrane having high permeability and high membrane strength; and a production method therefor. The present invention pertains to a composite hollow-fiber membrane that at least has a layer (A) and a layer (B), wherein the layer (A) contains a thermoplastic resin, the layer (A) is provided with a co-continuous structure comprising voids and a phase containing the thermoplastic resin, the co-continuous structure has a structural cycle of 1-1000 nm, and the hole area rate H.sub.A of the layer (A) and the hole area rate H.sub.B of the layer (B) fulfill the relation: H.sub.A<H.sub.B.

Excess water can be removed from blood by passing the blood through channels that are surrounded by nanotubes with spaces therebetween. Each channel is wide enough for blood to flow through, and the nanotubes are spaced close enough to each other to retain the blood within the channels. Gas passing through the spaces between the nanotubes outside the channels comes into contact with the blood at the outer boundaries of the channels, and the excess water in the blood evaporates into the gas. In other embodiments, an undesirable molecule (e.g., ammonia) can be removed from blood by passing the blood through channels that are surrounded by nanotubes with spaces therebetween. Gas passing through the spaces between the nanotubes outside the channels comes into contact with the blood at the outer boundaries of the channels, and the undesirable molecule in the blood diffuses into the gas.

A molecule can be removed from blood by passing the blood through channels that are surrounded by nanotubes with spaces therebetween. Each channel is wide enough for blood to flow through, and the nanotubes are spaced close enough to each other to retain the blood within the channels. Gas passing through the spaces between the nanotubes outside the channels comes into contact with the blood at the outer boundaries of the channels, and the molecule in the blood diffuses into the gas. In other embodiments, a molecule can be introduced into blood by passing the blood through channels that are surrounded by nanotubes with spaces therebetween. Gas that includes the molecule passes through the spaces between the nanotubes outside the channels. The gas comes into contact with the blood at the outer boundaries of the channels, and the molecule in the gas diffuses into the blood.

The present disclosure relates to a filtration device comprising a plurality of hollow fiber membranes, a process for its production, and its use for the dead-end filtration of infusion liquids.

The invention relates to an undulated thermostable hollow fiber membrane of reduced wall thickness, wherein the wall thickness amounts to 20 m or greater and 30 m or less and the waveform of the hollow fiber membrane exhibits a wavelength in the range of from more than 1 mm and less than 5 mm. In particular, the invention relates to a method for producing an undulated thermostable hollow fiber membrane of lower wall thickness.

The present invention provides a hollow fiber membrane module which makes it possible to concentrate incubated platelets by efficiently removing water from an incubated platelet suspension liquid containing incubated platelets while suppressing deterioration of the function of the incubated platelets. The present invention provides an incubated platelet concentration module in which a plurality of hollow fiber membranes each having pores with an average pore diameter of 2 m or less on a surface of the hollow fiber membrane are packed in a casing having at least one inlet for supplying an incubated platelet suspension liquid before concentration into the hollow fiber membranes, wherein a value (X/Y1) obtained by dividing a total cross-sectional area (X) of the plurality of hollow fiber membranes by a total cross-sectional area (Y1) of the least one inlet is 4.0 or less.

The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.

Disclosed herein is a single pass cross flow filtration system comprising: a filtration module comprising two or more filtration segments fluidly connected in series, each having an upstream side and a downstream side; wherein each filtration segment comprises hollow fiber filter membranes, and wherein, when in use, the desired permeate flux is controlled by a configuration comprising; each filtration segment having a selected length; the hollow fiber filter membranes of each filtration segment having a selected inner diameter, wherein the selected inner diameters may be the same or different, provided that at least one of the selected inner diameters differs from the others, and provided that the two or more filtration segments are arranged such that no inner diameter is larger on the upstream side; and one or more pumps, mounted in the permeate channel.

A thin-film-composite hollow-fiber membrane includes a phase-inversion layer, which is in the form of a hollow fiber, and an active layer coated on the phase-inversion layer. The active layer selectively allows passage of water molecules but rejects at least some dissolved ions. The thin-film-composite hollow-fiber membrane can have an internal burst pressure of at least 4 MPa. In a method for forming the membrane, the polymer concentration in the spinning dope from which the hollow-fiber substrate is formed can have a polymer concentration no greater than 5% below the critical concentration.