Disclosed herein is a single pass cross flow diafiltration system comprising: a filtration module having; two or more filtration segments fluidly connected in series, each having an upstream side and a downstream side; wherein each filtration segment comprises hollow fiber filter membranes, and wherein each filtration segment has a selected length; wherein the hollow fiber filter membranes of each filtration segment have a selected inner diameter; wherein the selected inner diameter of each filtration segment may be the same or different, provided that at least one selected inner diameter differs from another selected inner diameter, and provided that the two or more filtration segments are arranged such that no selected inner diameter in a given filtration segment is larger on the upstream side; one or more pumps, mounted to urge fluid flow; and one or more points of introduction of a diadiluent, each of said points of introduction being fluidly connected to an upstream filtration segment.

A hydrophobic-oleophilic and hollow fiber composite membrane includes hollow tubular braids and surface separation layers coated on the outer surfaces of the hollow tubular braids. Membrane-forming polymers in the surface separation layers are polyvinylidene fluoride, and all other components are hydrophobic ingredients, including graphene. A preparing method includes preparing hollow tubular braids by two-dimensional braided technique using polyester filaments, wherein the hollow tubular braids are used as the reinforcements. The method further includes mixing polyvinylidene fluoride, hydrophobic pore-forming agent, and the rest of solvent to prepare a casting solution of surface separation layer. The method further includes pre-treatment processing of the reinforcements; and coating the casting solution of surface separation layer on the outer surface of the processed reinforcements through a spinning spinneret to form a primary membrane. The reinforcements are replaced by the primary after post-processing, and repeating the coating process.

A filtration module according to an embodiment of the present invention includes a plurality of hollow fiber membranes held while being aligned in one direction and a pair of holding members that fix both ends of the hollow fiber membranes. In the holding members, an existence region where the hollow fiber membranes exist has a rectangular shape in a direction perpendicular to the direction in which the hollow fiber membranes are aligned; a ratio of an average length of the existence region in a long side direction to an average length of the existence region in a short side direction is 10 or more and 50 or less; an average outer diameter of the hollow fiber membranes is 1 mm or more and 6 mm or less; and a ratio of an average effective length of the hollow fiber membranes between the holding members to the average length of the existence region in the short side direction is 40 or more and 200 or less.

The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.

An environmental control system includes an air conditioning subsystem and a contaminant removal subsystem downstream of the environment to be conditioned. The contaminant removal subsystem includes: a first gas-liquid contactor-separator; a second gas-liquid contactor-separator; and a dehumidifier disposed either upstream of the first gas-liquid contactor-separator or downstream of the second gas-liquid contactor-separator.

A hollow-fiber membrane according to an aspect of the present disclosure contains a polytetrafluoroethylene or a modified polytetrafluoroethylene as a main component and has an average outer diameter of 1 mm or less and an average inner diameter of 0.5 mm or less. In a measurement of a heat of fusion of the polytetrafluoroethylene or the modified polytetrafluoroethylene with a differential scanning calorimeter, when the polytetrafluoroethylene or modified polytetrafluoroethylene is subjected to a first step of heating from room temperature to 365° C., a second step of cooling from 365° C. to 350° C., maintaining the temperature, subsequently cooling from 350° C. to 330° C., and further cooling from 330° C. to 305° C., and a third step of cooling from 305° C. to 245° C. at a rate of −50° C./min and subsequently heating from 245° C. to 365° C. at a rate of 10° C./min, a heat of fusion from 296° C. to 343° C. in the third step is 30.0 J/g or more and 45.0 J/g or less.

The present invention addresses the problem of providing: a composite hollow-fiber membrane having high permeability and high membrane strength; and a production method therefor. The present invention pertains to a composite hollow-fiber membrane that at least has a layer (A) and a layer (B), wherein the layer (A) contains a thermoplastic resin, the layer (A) is provided with a co-continuous structure comprising voids and a phase containing the thermoplastic resin, the co-continuous structure has a structural cycle of 1-1000 nm, and the hole area rate H.sub.A of the layer (A) and the hole area rate H.sub.B of the layer (B) fulfill the relation: H.sub.A<H.sub.B.

The present disclosure relates to a hemodialysis membrane for the treatment of restless leg syndrome (RLS), especially in severe and very severe cases and/or in patients which suffer from kidney failure and already receive hemodialysis. The present disclosure therefore also relates to methods of treating restless leg syndrome. The treatment and method encompasses using a hemodialysis membrane which is characterized in that it comprises at least one hydrophobic polymer and at least one hydrophilic polymer and in that it has a MWRO of between 8.5 and 14.0 kD and a MWCO of between 55 kD and 130 kD.

A membrane distillation device, provided with a membrane distillation module including a plurality of hydrophobic porous hollow fiber membranes, and a condenser for condensing water vapor extracted from the module. The average pore diameter of the porous hollow fiber is 0.01-1 μm. The filling ratio of the porous hollow fiber of the membrane distillation module is 10-80%, and the pressure condition for the membrane distillation is equal to or greater than 1 kPa and equal to or less than the saturated vapor pressure of water at the temperature of the water being treated.

The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.