A hollow-fiber membrane according to an aspect of the present disclosure contains a polytetrafluoroethylene or a modified polytetrafluoroethylene as a main component and has an average outer diameter of 1 mm or less and an average inner diameter of 0.5 mm or less. In a measurement of a heat of fusion of the polytetrafluoroethylene or the modified polytetrafluoroethylene with a differential scanning calorimeter, when the polytetrafluoroethylene or modified polytetrafluoroethylene is subjected to a first step of heating from room temperature to 365° C., a second step of cooling from 365° C. to 350° C., maintaining the temperature, subsequently cooling from 350° C. to 330° C., and further cooling from 330° C. to 305° C., and a third step of cooling from 305° C. to 245° C. at a rate of −50° C./min and subsequently heating from 245° C. to 365° C. at a rate of 10° C./min, a heat of fusion from 296° C. to 343° C. in the third step is 30.0 J/g or more and 45.0 J/g or less.

The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.

The invention relates generally to methods of preparing one or more organs from a donor for transplantation to a recipient comprising passing blood from the donor through an extracorporeal membrane having a plurality of pores having an average pore size of at least 60 kDa.

The Invention relates to a method for preparing a multichannel hollow fiber membrane. According to a certain ratio, ceramic powder, a macromolecular polymer, an organic solvent, and a dispersant are mixed evenly to prepare a membrane casting solution; and after bubble removing processing is performed on the membrane casting solution, a membrane green body is formed with the cooperation of a multichannel hollow fiber die and phase inversion. After the membrane green body is roasted at a high temperature, a multichannel ceramic hollow fiber membrane is formed. The multichannel ceramic hollow fiber membrane has an asymmetric structure and a skeleton structure in an inner cavity and can meet the strength and flux requirements of a ceramic hollow fiber membrane.

The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.

The present disclosure relates to a microporous hollow fiber filter membrane having a large inner diameter and a thin wall. The fiber can be used for sterile filtration of liquids or removal of particles from liquids. The disclosure further relates to a method for producing the membrane and a filter device comprising the membrane.

The present invention is directed to a process for the preparation of a tube with an outer diameter in the range of from 10 μm to 250 μm consisting of a composition comprising a thermoplastic polyurethane as well as to a tube with an outer diameter in the range of from 10 μm to 250 μm consisting of a composition comprising a thermoplastic polyurethane obtained or obtainable by the process according to the invention. The invention is further directed to the use of a tube according to the invention as a tube for the transportation of a fluid or as gas membrane tube or as an elastic fiber.

Disclosed herein is a single pass cross flow diafiltration system comprising: a filtration module having; two or more filtration segments fluidly connected in series, each having an upstream side and a downstream side; wherein each filtration segment comprises hollow fiber filter membranes, and wherein each filtration segment has a selected length; wherein the hollow fiber filter membranes of each filtration segment have a selected inner diameter; wherein the selected inner diameter of each filtration segment may be the same or different, provided that at least one selected inner diameter differs from another selected inner diameter, and provided that the two or more filtration segments are arranged such that no selected inner diameter in a given filtration segment is larger on the upstream side; one or more pumps, mounted to urge fluid flow; and one or more points of introduction of a diadiluent, each of said points of introduction being fluidly connected to an upstream filtration segment.

A hollow fiber membrane laminate that includes a plurality of hollow fiber membranes wound to form a plurality of layers in a cylinder shape. The hollow fiber membranes are wound around a central axis while reciprocating a feeding point of the hollow fiber membranes along a central axis. Hollow fiber membranes adjacent to each other in each respective layer are separated by a predetermined separation distance. A speed differential z is reduced for successive layers approaching an outer side of the cylinder to maintain the predetermined separation distance. The speed differential z has a value obtained by dividing a pitch of the hollow fiber membranes within a respective layer by a traverse reciprocating distance.

The present disclosure relates to a hemodialysis membrane for the treatment of restless leg syndrome (RLS), especially in severe and very severe cases and/or in patients which suffer from kidney failure and already receive hemodialysis. The present disclosure therefore also relates to methods of treating restless leg syndrome. The treatment and method encompasses using a hemodialysis membrane which is characterized in that it comprises at least one hydrophobic polymer and at least one hydrophilic polymer and in that it has a MWRO of between 8.5 and 14.0 kD and a MWCO of between 55 kD and 130 kD.