The present disclosure relates to a hemodialysis membrane for the treatment of restless leg syndrome (RLS), especially in severe and very severe cases and/or in patients which suffer from kidney failure and already receive hemodialysis. The present disclosure therefore also relates to methods of treating restless leg syndrome. The treatment and method encompasses using a hemodialysis membrane which is characterized in that it comprises at least one hydrophobic polymer and at least one hydrophilic polymer and in that it has a MWRO of between 8.5 and 14.0 kD and a MWCO of between 55 kD and 130 kD.

The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.

The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.

The invention relates to a hollow fiber membrane filter for purifying liquids with improved separation properties, comprising a cylindrical housing, first inflow or outflow spaces and second inflow or outflow spaces, each of which surrounds a first and a second end region of the cylindrical housing, the hollow fiber membrane filter having an aspect ratio of the actual effective length of the hollow fiber membrane and inner diameter of the cylindrical housing which is such that improved flow of a liquid against the hollow fiber membranes in the interior of the cylindrical housing can take place.

The present disclosure relates to capillary dialyzers for blood purification comprising from 85-95% crimped fibers and from 5-15% non-crimped fibers.

Disclosed are a bundle of hollow fiber membranes to improve use efficiency of the hollow fiber membranes and a method of manufacturing the same. The bundle of hollow fiber membranes includes a plurality of yarns to form fluid channels and serve as spacers disposed between the hollow fiber membranes to create a bundle. The method includes spinning including supplying a spinning dope to a nozzle and conducting spinning to form a plurality of hollow fiber membranes, coagulating the hollow fiber membranes formed during spinning, and yarn feeding including inserting a plurality of yarns between the hollow fiber membranes to form a bundle. The method is effective in uniformly distributing a fluid through fluid channels formed between the hollow fiber membranes and maximizes usage efficiency of the hollow fiber membranes.

The present invention provides a medical material and a blood purification apparatus each having high anti-thrombotic properties and high safety. The apparatus is produced by incorporating therein a medical material which has a hydrophilic copolymerization polymer present on a surface thereof which is to be in contact with blood, wherein particulate protuberances each having a particle diameter of 50 nm or more are present on the surface which is to be in contact with blood at a density of 3 particles/?m.sup.2 or less and the relaxation time of adsorbed water in the hydrophilic copolymerization polymer is 2.5?10.sup.?8 seconds or shorter and 5.0?10.sup.?10 seconds or longer at ?40? C.

The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.

The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.

A filter module of an extracorporeal blood treatment machine with a filter casing in which a hollow fiber bundle is attached whose hollow fibers comprise a hollow fibre wall made of a semi-permeable membrane, and whereby in their longitudinal extension the hollow fibers comprise a number of changes in their diameter. An amplitude of 0.1 to 1 mm is achieved for the exterior diameter of the respective hollow fiber starting from the hollow fiber's axis, whereby the periodicity provided in the axial direction of the hollow fiber is within a range of 1 to 10 cm and on the inside of the filter casing at least one radial constriction is configured or provided by which the fiber bundle is locally constricted.