Certain aspects of the present disclosure provide a flexible scaffold implant comprising a plurality of layered structures, the plurality of layered structures comprising: a first layered structure having a three-dimensional (3D) shape and formed from a bioresorbable material, and a second layered structure conforming to the corresponding 3D shape of the first layered structure and formed from the bioresorbable material. The first layered structure is arranged in proximity to the second layered structure. The first layered structure is configured to dissolve for resorption at a different rate than the second layered structure based on design elements of the first layered structure and the second layered structure. The plurality of layered structures are flexible.

A bone implant for enclosing bone material is provided. The bone implant comprises a nonwoven mesh having an inner surface and an outer surface opposing the inner surface and configured to receive a bone material when the inner surface of the mesh is in an open configuration. A plurality of projections are disposed on or in at least a portion of the inner surface of the mesh, the outer surface of the mesh or both the inner and outer surfaces of the mesh, the plurality of projections extending from at least the portion of the inner surface, the outer surface of the mesh or both the inner and outer surfaces of the mesh and are configured to engage a section of the inner surface of the mesh or a section of the outer surface of the mesh or both in a closed configuration so as to enclose the bone material.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provide high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold is typically formed from non-degradable material and will be modified to expand and/or uncage after deployment.

An integrally woven manifold is disclosed including a primary portion having a primary lumen disposed therein, a secondary portion branching off the primary portion, the secondary portion having a secondary lumen disposed therein in fluid communication with the primary lumen, and a first transitional portion connecting the primary portion to the secondary portion, the first transitional portion having a first aperture through which the secondary lumen fluidly communicates with the primary lumen. The primary portion has a first weave pattern, the secondary portion has at least a second weave pattern, and the first transitional portion is free of punctures, cuts, and bursts. A method for forming the integrally woven manifold is disclosed including continuously interlacing warp and weft to form the primary portion, intermittently interlacing the warp and the weft to form the secondary portion, and disengaging and reengaging the warp and the weft to form the first transitional portion.

An improved gastroesophageal reflux preventer and related methods are provided. The improved gastroesophageal reflux preventer may include an absorbable material able to be placed in contact with a body organ and configured to induce a scarification of the body organ in response to absorption by the body organ of the material. In this manner, a proximate sphincter may be tightened, such as to ameliorate reflux through a gastroesophageal sphincter.

Luminal grafts and methods of making and using the same. An exemplary luminal graft of the present disclosure is configured as a generally tubular element configured for nerve cells to grow therethrough and comprises at least one sheet of biological tissue having elastin fibers and collagen fibers, with the elastin fibers being a dominant component thereof; and a plurality of microchannels formed on a surface of the at least one sheet of biological tissue, each of the microchannels extending longitudinally between a first end and a second end of the at least one sheet of biological tissue and configured to provide intraluminal structural guidance to nerve cells proliferating therethrough.

An implantable medical device may comprise an elongated tubular body having a scaffolding forming a plurality of cells. A polymeric covering may be disposed over at least a portion of the stent. The covering may include a plurality of voids formed in an outer surface thereof. An extracellular matrix material coating may be disposed over the polymeric covering and within the plurality of voids.

The invention relates to a mesh support device (10; 20) for supporting a breast implant (30), wherein the mesh support device (10; 20) is tubular and comprises a first circumferential mesh area (11; 21), which is characterized by a first set of mesh characteristics and which has a first circumferential length, and a second circumferential mesh area (12; 22), which is characterized by a second set of mesh characteristics and which has a second circumferential length, the first set of mesh characteristics being different from the second set of mesh characteristics. The invention relates also to a breast implant device comprising the breast implant (30) and the mesh support device (10; 20).

The present disclosure provides devices, systems, and methods relating to performing a medical procedure. In particular, the present disclosure is directed to devices, systems, and methods for positioning and securing a body implant in a subject in a manner that is customizable for each subject and minimizes implant migration. The devices, systems, and methods described herein utilize biocompatible and biodegradable materials that provide enhanced long-term fixation of the implant.