A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

Soft tissue repair grafts are described comprising an anti-adhesion layer, a structural layer, and a localization layer. These layers may be distinct or integrated into one substrate. The term layer is used to distinguish tissue repair graft functionality rather than distinct material layers. The distinct layers of functionality may comprise a single plane of a substance.

A bifunctional expandable stent delivery assembly having a bifunctional expandable stent, a breakable cover, and a balloon. The bifunctional expandable stent has a balloon-expandable body portion and a self-expandable trumpet portion. The breakable cover fits over only the self-expandable trumpet portion and prevents self-expansion. The balloon is used to expand the balloon-expandable portion, which breaks the breakable cover and allows the self-expandable trumpet portion to self-expand. A method of stenting a patient using the bifunctional expandable stent delivery assembly is also provided.

The invention relates to medicine, in particular, to gynecology and urology, namely, to for ligature delivery system for axial fixation of pelvic floor structures in pelvic organ prolapse and stress urinary incontinence. Ligature delivery system for axial fixation of pelvic floor structures in pelvic organ prolapse and stress urinary incontinence consisting of the mesh material that is woven from a non-biodegradable and biodegradable monofilament threads, according to the invention so that non-biodegradable threads are arranged along to the implant axis and are not linked with each other. The technical effect is providing the axial support that is physiological for apical structures of pelvic floor and minimizing risks of mesh-associated postsurgical complications.

Biocompatible intraocular implants may include a brimonidine free base and a biodegradable polymer associated with the brimonidine free base to facilitate the release of the brimonidine free base into an eye with the polymer matrix lasts a period of time of not more than twice the drug release duration, but more than the drug release duration.

A vascular filter system for deploying a vascular filter utilizes a plurality of tensors that extend radially outward from a deployment sheath. The ends of the tensors are coupled with an attachment ring of the vascular filter and a plurality of attachment barbs are coupled with the attachment ring for securing the filter to the vessel wall. A method for retrieving the vascular filter from the vessel utilizes a reverse curve catheter, a guidewire that extends therethrough and an intravascular snare. The guidewire is advanced around the filter and into the snare which secures the guidewire around the filter for retrieval. A vessel distention device utilizes one or more distention tensors having a distention feature on the extended end, such as a blunt tip, to press on the inside vessel wall. The distention tensors extend out radially from a sheath to press on the vessel wall.

Absorbable implants for breast surgery that conform to the breast parenchyma and surrounding chest wall have been developed. These implants support newly lifted breast parenchyma, and/or a breast implant. The implants have mechanical properties sufficient to support a reconstructed breast, and allow the in-growth of tissue into the implant as it degrades. The implants have a strength retention profile allowing the support of the breast to be transitioned from the implant to regenerated host tissue, without significant loss of support. Three-dimensional implants for use in minimally invasive mastopexy/breast reconstruction procedures are also described, that confer shape to a patient's breast. These implants are self-reinforced, can be temporarily deformed, implanted in a suitably dissected tissue plane, and resume their preformed three-dimensional shape. The implants are preferably made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof. The implants have suture pullout strengths that can resist the mechanical loads exerted on the reconstructed breast.

A vascular stent including at least two layers of magnesium alloy latticed support walls, a cavity, and an expandable balloon. The expandable balloon is disposed in the cavity.

A replacement heart valve prosthesis for transcatheter repair of a native valve, the replacement heart valve comprises a valve construct mounted to the exterior surface of an expandable frame. The frame comprises an expandable region near the distal end of the frame, and a cusp region near the proximal region comprising a plurality of valve attachment features. The valve construct may be attached to the valve construct at least at the valve attachment features. The replacement heart valve prosthesis of present disclosure may be a more durable and long-lasting valve that has added benefits by placing valve tissue between the expandable frame and native cardiac tissue.

A void occlusion device that includes a scaffold defining a plurality of voids and a reinforcement member is described. The scaffold is configured to permit the infiltration of human tissue into the plurality of voids. The reinforcement member extends through at least a portion of the scaffold and is configured to resist compressive forces exerted on the scaffold. Also described are embodiments where the void occlusion device is biocompatible, bioresorbable, elastic, and suitable for radio imaging.