The present disclosure relates to a microporous hollow fiber filter membrane having a large inner diameter and a thin wall. The fiber can be used for sterile filtration of liquids or removal of particles from liquids. The disclosure further relates to a method for producing the membrane and a filter device comprising the membrane.

The present disclosure relates to a microporous hollow fiber filter membrane having a large inner diameter and a thin wall. The fiber can be used for sterile filtration of liquids or removal of particles from liquids. The disclosure further relates to a method for producing the membrane and a filter device comprising the membrane.

A method for coating a porous support with a thin membrane selective layer via interfacial free-radical polymerization. The method is carried out by immersing a porous support in a monomer-containing solution, removing the porous support from the solution, covering the porous support with a second solution immiscible with the first solution, the second solution containing a polymerization initiator, activating the initiator to effect polymerization of the monomer, and washing the porous support having the membrane selective layer. Also disclosed are membranes prepared by the method and filtration methods using the membranes.

A method for coating a porous support with a thin membrane selective layer via interfacial free-radical polymerization. The method is carried out by immersing a porous support in a monomer-containing solution, removing the porous support from the solution, covering the porous support with a second solution immiscible with the first solution, the second solution containing a polymerization initiator, activating the initiator to effect polymerization of the monomer, and washing the porous support having the membrane selective layer. Also disclosed are membranes prepared by the method and filtration methods using the membranes.

A method for forming an isoporous graded film comprising multiblock copolymers and isoporous graded films. The films have a surface layer and a bulk layer. The surface layer can have at least 110.sup.14 pores/m.sup.2 and a pore size distribution (d.sub.max/d.sub.min)) of less than 3. The bulk layer has an asymmetric structure. The films can be used in filtration applications.

A method for forming an isoporous graded film comprising multiblock copolymers and isoporous graded films. The films have a surface layer and a bulk layer. The surface layer can have at least 110.sup.14 pores/m.sup.2 and a pore size distribution (d.sub.max/d.sub.min)) of less than 3. The bulk layer has an asymmetric structure. The films can be used in filtration applications.

The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.

The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.

An article that can be used for biomaterial capture comprises

(a) a porous substrate; and

(b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.

An article that can be used for biomaterial capture comprises

(a) a porous substrate; and

(b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.