The present invention relates to a mixed-matrix composition comprising polymer having a fractional free volume of at least 0.1 and porous particles.

The present invention relates to a mixed-matrix composition comprising polymer having a fractional free volume of at least 0.1 and porous particles.

Embodiments for a crosslinked alkoxysilyl polynorbornene homopolymer and methods of making crosslinked alkoxysilyl polynorbornene homopolymer are provided, where the method comprises polymerizing through addition polymerization or ring opening metathesis polymerization a norbornene monomer comprising an alkoxysilyl moiety in the presence of a catalyst to produce an alkoxysilyl modified polynorbornene homopolymer, and producing a crosslinked alkoxysilyl polynorbornene homopolymer through sol-gel initiated crosslinking of the alkoxysilyl modified polynorbornene homopolymer at ambient conditions, or acid-catalyzed conditions.

The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.

The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.

A substrate surface may be modified with a polymer coating to render the surface suitable for plasma functionalization. The polymer coating is deposited onto the surface at ambient temperature to a thickness of less than 0.1 μm. The polymer coating includes poly(p-xylylene) or a derivative thereof, and is capable of penetrating into pores of a porous substrate while no substantially altering the porosity of the substrate. The coated substrate is selected from a material lacking a primary or secondary aliphatic hydrogen atom.

The present invention provides an intrinsically anti-microbial hollow fiber membrane for filtration of liquids. The membrane comprises a plurality of porous hollow bilayer membrane fibers wherein the liquid enters from outside of the fiber, passing through the porous membrane into the lumen of the fiber and coming out from the hollow ending of the fiber, wherein this configuration provides a liquid outside-in arrangement and retains the filtrate outside. It means that membrane of the invention has built in characteristics to act against microbes in order to provide the use with a safe liquid free from microbes. The outer side or outer wall of the hollow fibers may be configured to become hydrophobic whereas inner side or inner wall of the hollow fiber membrane may be configured to become hydrophilic to enhance the water permeability to a great extent. The hollow fiber membrane may be configured to give it an intrinsic anti-microbial capability. A device containing above said membrane has also been disclosed.

A two-layer membrane including a polymer layer and a support layer, the polymer layer being disposed on a surface of the support layer. The polymer layer, having a pore size of at most 50 nm and a thickness of 5 nm to 10 μm, is formed of an amphiphilic copolymer that contains both charged groups and hydrophobic groups. The support layer has a pore size of 3 nm to 10 μm, which is larger than the pore size of the polymer layer. Also disclosed is a process of filtering a liquid using the two-layer membrane described above.

A two-layer membrane including a polymer layer and a support layer, the polymer layer being disposed on a surface of the support layer. The polymer layer, having a pore size of at most 50 nm and a thickness of 5 nm to 10 μm, is formed of an amphiphilic copolymer that contains both charged groups and hydrophobic groups. The support layer has a pore size of 3 nm to 10 μm, which is larger than the pore size of the polymer layer. Also disclosed is a process of filtering a liquid using the two-layer membrane described above.

There are provide a cell separation filter with which cells can be separated without damage and can suppress adsorption, a filtering device, and a manufacturing method for a cell separation filter. The cell separation filter is composed of a nonwoven fabric that is formed of fibers containing a water-insoluble polymer and a hydrophilizing agent and has a fiber density difference in the film thickness direction. The nonwoven fabric has an average through-hole diameter of 2.0 μm or more and less than 10.0 μm, a void ratio of 75% or more and 98% or less, a film thickness of 100 μm or more, and a critical wet surface tension of 72 mN/m or more.