The invention relates to the field of microfluidic detection and analyses. Described herein are methods and devices for the separation, detection and measurement of molecules in liquid samples. Certain aspects of the invention concerns the separation of analyte(s) of interest based on the combined use of: (i) membrane separation, (ii) an electric field and/or a magnetic field; and (iii) capillary action and/or gravity. Envisioned applications include separation, detection and/or measurement of analytes in blood samples, food samples and environmental samples. One particular example is a portable biosensor for the detection and measurement of histamine and diamine oxidase (DOA) in a drop of blood.

The invention relates to the field of microfluidic detection and analyses. Described herein are methods and devices for the separation, detection and measurement of molecules in liquid samples. Certain aspects of the invention concerns the separation of analyte(s) of interest based on the combined use of: (i) membrane separation, (ii) an electric field and/or a magnetic field; and (iii) capillary action and/or gravity. Envisioned applications include separation, detection and/or measurement of analytes in blood samples, food samples and environmental samples. One particular example is a portable biosensor for the detection and measurement of histamine and diamine oxidase (DOA) in a drop of blood.

A 3-dimensional (3D) nasal pod structure is described having a filter that fits in the nasal cavity to capture particles such as pollen, allergens, pollution particles present in air when breathing through the nose.

A 3-dimensional (3D) nasal pod structure is described having a filter that fits in the nasal cavity to capture particles such as pollen, allergens, pollution particles present in air when breathing through the nose.

A method for automated processing of a blood product, the method comprising providing a reusable separation apparatus controlled by a microprocessing unit, said apparatus configurable with settings and configured to associate with a disposable circuit comprising a separator and in communication with a source blood product having a first concentration and first volume. The apparatus and disposable circuit are configured to flow the source blood product into an inlet of the separator and separate supernatant of the source blood product from a first outlet of the separator into a filtrate container. The apparatus and disposable circuit are also configured to separate platelets and remaining supernatant from a second outlet of the separator into a retentate container, wherein the platelets and remaining supernatant in the retentate container have a second concentration greater than the first concentration and second volume less than the first volume.

A method for automated processing of a blood product, the method comprising providing a reusable separation apparatus controlled by a microprocessing unit, said apparatus configurable with settings and configured to associate with a disposable circuit comprising a separator and in communication with a source blood product having a first concentration and first volume. The apparatus and disposable circuit are configured to flow the source blood product into an inlet of the separator and separate supernatant of the source blood product from a first outlet of the separator into a filtrate container. The apparatus and disposable circuit are also configured to separate platelets and remaining supernatant from a second outlet of the separator into a retentate container, wherein the platelets and remaining supernatant in the retentate container have a second concentration greater than the first concentration and second volume less than the first volume.

Disclosed is a hollow fiber that contains an outer layer made of a first polymer and an inner layer made of a second polymer, the inner layer including at its outer surface a macrovoid-free thin interface sublayer in contact with the inner surface of the outer layer. The first polymer is immiscible with the second polymer. Also disclosed is a process of preparing the above-described hollow fiber.

Disclosed is a hollow fiber that contains an outer layer made of a first polymer and an inner layer made of a second polymer, the inner layer including at its outer surface a macrovoid-free thin interface sublayer in contact with the inner surface of the outer layer. The first polymer is immiscible with the second polymer. Also disclosed is a process of preparing the above-described hollow fiber.

The invention relates to a gas in/outlet-adapter system for a container/rack assembly for a diagnostic robot comprising: a receptacle (15) comprising a gas-inlet wherein the receptacle (15) is attached to a container (12), a nozzle (16) comprising a gas-outlet wherein the nozzle (16) is attached to a rack to supply the container (12) via the receptacle (15) with a gas at a defined pressure level, wherein the receptacle (12) provides one opening (24) which provides for a fluidic contact to the interior of the container (12) and a second opening (25) which provides for a gas leak-proof connection to the nozzle (16) on the rack when the receptacle (15) is placed over the nozzle (16), and wherein the nozzle (16) provides one opening (26)which provides for a fluidic contact to a tubing system of the rackand a second opening (27)which provides for a fluidic contact to the nozzle (16) when the receptacle (15) is placed to cover the nozzle (15).

The invention relates to a dialysis cell for sample preparation for a chemical analysis method, in particular for ion chromatography. The dialysis cell comprises a donor channel and an acceptor channel extending parallel thereto. The donor channel and the acceptor channel are separated from each other by a selectively permeable dialysis membrane. In particular, an analyte that is dissolved in a donor solution in the donor channel can enter through the dialysis membrane into the acceptor solution in the acceptor channel. The acceptor channel has at least in some sections a volume that is smaller than the volume of the donor channel extending parallel thereto. Acceptor and donor channels are formed from half-cells, between which the dialysis membrane is arranged, wherein the donor channel and the acceptor channel are designed in each case as a recess in a contact surface of one of the half-cells with the dialysis membrane.