Composite polyether block amide (PEBA) copolymer tubes incorporate an ultra-thin PEBA layer that enables rapid moisture transfer and exchange through the tube. A composite PEBA film may include a porous scaffold support and may be formed or incorporated into the composite PEBA tube. A porous scaffold support may be coated or imbibed with PEBA to form a composite PEBA film. A composite PEBA film may be wrapped on a mandrel or over a porous scaffold support to form a composite PEBA tube. A film layer may be applied over a wrapped composite PEBA film to secure the layers together. The film layer by applied by dipping, spraying or painting.

Composite polyether block amide (PEBA) copolymer tubes incorporate an ultra-thin PEBA layer that enables rapid moisture transfer and exchange through the tube. A composite PEBA film may include a porous scaffold support and may be formed or incorporated into the composite PEBA tube. A porous scaffold support may be coated or imbibed with PEBA to form a composite PEBA film. A composite PEBA film may be wrapped on a mandrel or over a porous scaffold support to form a composite PEBA tube. A film layer may be applied over a wrapped composite PEBA film to secure the layers together. The film layer by applied by dipping, spraying or painting.

A filtering device is for obtaining a chemical liquid by purifying a liquid to be purified, and the filtering device has an inlet portion, an outlet portion, a filter A, at least one filter B different from the filter A, and a flow path which includes the filter A and the filter B arranged in series and extends from the inlet portion to the outlet portion, in which the filter A has a porous base material made of polyfluorocarbon and a coating layer which is disposed to cover the porous base material and contains a resin having an adsorptive group.

A filtering device is for obtaining a chemical liquid by purifying a liquid to be purified, and the filtering device has an inlet portion, an outlet portion, a filter A, at least one filter B different from the filter A, and a flow path which includes the filter A and the filter B arranged in series and extends from the inlet portion to the outlet portion, in which the filter A has a porous base material made of polyfluorocarbon and a coating layer which is disposed to cover the porous base material and contains a resin having an adsorptive group.

Hollow fiber membranes, membrane contactors, and related production and use methods. The asymmetric hollow fiber membranes include a porous substrate having a multiplicity of pores and including at least one semi-crystalline thermoplastic polyolefin (co)polymer. A skin layer including at least one polydiorganosiloxane polyoxamide copolymer overlays the porous substrate. The skin layer is less porous than the porous substrate and forms an outer surface of the asymmetric hollow fiber membrane, while the porous substrate forms an inner surface of the hollow fiber membrane. The skin layer is preferably nonporous.

Hollow fiber membranes, membrane contactors, and related production and use methods. The asymmetric hollow fiber membranes include a porous substrate having a multiplicity of pores and including at least one semi-crystalline thermoplastic polyolefin (co)polymer. A skin layer including at least one polydiorganosiloxane polyoxamide copolymer overlays the porous substrate. The skin layer is less porous than the porous substrate and forms an outer surface of the asymmetric hollow fiber membrane, while the porous substrate forms an inner surface of the hollow fiber membrane. The skin layer is preferably nonporous.

A serial filtration system for liquid purification includes a preliminary-stage reverse-osmosis (RO) module and a first-stage, high-permeability, reverse-osmosis (HiRO) module. Both modules include (a) a chamber including an inlet, a retentate outlet, and a permeate outlet, and (b) at least one membrane separating the chamber into a retentate side on an upstream side of the membrane and a permeate side on a downstream side of the membrane. The membrane in the preliminary stage is an RO membrane, while the membrane in the first stage is an oxidized membrane. The first-stage inlet is in fluid communication with the preliminary-stage, retentate outlet; and the oxidized membrane in the first stage, comprises an oxidized polyamide active layer coated on a porous support, wherein the oxidized polyamide active layer has an atomic oxygen/nitrogen ratio of at least 1.5.

A serial filtration system for liquid purification includes a preliminary-stage reverse-osmosis (RO) module and a first-stage, high-permeability, reverse-osmosis (HiRO) module. Both modules include (a) a chamber including an inlet, a retentate outlet, and a permeate outlet, and (b) at least one membrane separating the chamber into a retentate side on an upstream side of the membrane and a permeate side on a downstream side of the membrane. The membrane in the preliminary stage is an RO membrane, while the membrane in the first stage is an oxidized membrane. The first-stage inlet is in fluid communication with the preliminary-stage, retentate outlet; and the oxidized membrane in the first stage, comprises an oxidized polyamide active layer coated on a porous support, wherein the oxidized polyamide active layer has an atomic oxygen/nitrogen ratio of at least 1.5.

The present disclosure relates to a dialysis apparatus comprising a membrane having at least one protein from the lipocalin family bound thereon. The disclosure further relates to methods of removing non-polar, hydrophobic and/or protein bound uremic toxins from a target subject utilizing the dialysis apparatus described herein as well as methods of extracorporeal detoxification.

The present disclosure relates to a dialysis apparatus comprising a membrane having at least one protein from the lipocalin family bound thereon. The disclosure further relates to methods of removing non-polar, hydrophobic and/or protein bound uremic toxins from a target subject utilizing the dialysis apparatus described herein as well as methods of extracorporeal detoxification.