The present disclosure relates to hollow fiber membrane filtration devices for the production of ready-to-use dialysis fluid by forward osmosis, and a cost-efficient and simple method and system for preparing ready-to-use dialysis fluid from raw water and liquid dialysis concentrate by forward osmosis.

A composite semipermeable membrane includes a porous support membrane, a separation functional layer containing a polyamide disposed on the porous support membrane, and a coating layer disposed on the separation functional layer, wherein a water contact angle of a surface of the coating layer is 40° or less, and a protein adsorption force of the surface of the coating layer is 0.4 nN or less.

Provided is a method for preparing a peptide emulsion formulation capable of preparing a desired peptide emulsion formulation. A method for preparing a peptide emulsion formulation includes a step of mixing an aqueous solution containing a compound consisting of an amino acid sequence represented by Formula (1), a pharmaceutically acceptable salt thereof, and a peptide consisting of an amino acid sequence represented by WAPVLDFAPPGASAYGSL (SEQ ID NO: 1) or a pharmaceutically acceptable salt thereof with an oily formulation and applying vibration mixing; and a membrane emulsification step of passing a premixed solution after the vibration mixing through a membrane filter to emulsify the premixed solution.

Provided is a method for preparing a peptide emulsion formulation capable of preparing a desired peptide emulsion formulation. A method for preparing a peptide emulsion formulation includes a step of mixing an aqueous solution containing a compound consisting of an amino acid sequence represented by Formula (1), a pharmaceutically acceptable salt thereof, and a peptide consisting of an amino acid sequence represented by WAPVLDFAPPGASAYGSL (SEQ ID NO: 1) or a pharmaceutically acceptable salt thereof with an oily formulation and applying vibration mixing; and a membrane emulsification step of passing a premixed solution after the vibration mixing through a membrane filter to emulsify the premixed solution.

The present invention relates to highly selective ultrathin polymer nanofilm; its composite membrane; its method of preparation. Composite membranes are produced via interfacial polymerization with addition of surface active reagents (SLS) to aqueous phase of piperazine amine and reacted with trimesoyl chloride. Fabricated ultrathin polymer nanofilm composite membrane gives high water permeance in range of 47.9-59.6 Lm.sup.−2h.sup.−1bar.sup.−1 with high rejection of Na.sub.2SO.sub.4 (91.77-98.47%); low rejection of MgCl.sub.2 (3.2-10.0%); NaCl (8.9-15.3%); high water permeance in range of 8.1-16.4 Lm.sup.−2h.sup.−1bar.sup.−1 with high rejection of Na.sub.2SO.sub.4 (99.81-99.99%); high rejection of MgCl.sub.2 (96.7-98.4%); NaCl (42.1-56.9%) when tested under 5 bar applied pressure at 25 (±1)° C. with 2 gL.sup.−1 feed. Ideal salt selectivity for NaCl/Na.sub.2SO.sub.4 is in range of 296.3-4310.

The present invention relates to a separation membrane including a thermoplastic polymer selected from a cellulose ester and a polyamide, in which, when regions obtained by dividing a cross-sectional surface perpendicular to a longitudinal direction of the separation membrane into 5 at an equal interval are defined as regions 1 to 5, all the regions 1 to 5 have a number average pore diameter changing rate a of −0.25 to 0.25, and at least one of the regions 1 to 5 is a region P that satisfies conditions (a) and (b): (a) a value of area average pore diameter D.sub.s/number average pore diameter D.sub.n is 2.50 to 6.00; and (b) a number average W of fine pores that are located at a distance smaller than L.sub.a from a center of respective coarse pores is 10 to 30.

The present invention relates to a separation membrane including a thermoplastic polymer selected from a cellulose ester and a polyamide, in which, when regions obtained by dividing a cross-sectional surface perpendicular to a longitudinal direction of the separation membrane into 5 at an equal interval are defined as regions 1 to 5, all the regions 1 to 5 have a number average pore diameter changing rate a of −0.25 to 0.25, and at least one of the regions 1 to 5 is a region P that satisfies conditions (a) and (b): (a) a value of area average pore diameter D.sub.s/number average pore diameter D.sub.n is 2.50 to 6.00; and (b) a number average W of fine pores that are located at a distance smaller than L.sub.a from a center of respective coarse pores is 10 to 30.

Water permeable membranes and methods of preparation are described. The water permeable membrane can comprise a porous support, and a polyamide layer comprising a crosslinked polyamide on a surface of the porous support, wherein the polyamide layer further comprises nanoparticles and a hydrophilic additive, and wherein the hydrophilic additive covalently bonds to the crosslinked polyamide. The crosslinked polyamide can be interfacially polymerized on the porous support. Methods for desalinating water, performing dialysis, or performing pervaporation using the water permeable membranes are disclosed.

Water permeable membranes and methods of preparation are described. The water permeable membrane can comprise a porous support, and a polyamide layer comprising a crosslinked polyamide on a surface of the porous support, wherein the polyamide layer further comprises nanoparticles and a hydrophilic additive, and wherein the hydrophilic additive covalently bonds to the crosslinked polyamide. The crosslinked polyamide can be interfacially polymerized on the porous support. Methods for desalinating water, performing dialysis, or performing pervaporation using the water permeable membranes are disclosed.

A chemical liquid manufacturing apparatus is provided. The manufacturing apparatus at least includes an ion exchange medium and an ion adsorption medium configured downstream from the ion exchange medium. A material of the ion adsorption medium includes a resin material having an amide bond or an imide bond. A manufacturing method of a chemical liquid using the apparatus is also provided.