The invention relates to the field of biomimetic membranes with artificial water channels, notably the use thereof in the context of the production and management of drinking water. The present invention relates to a biomimetic membrane with artificial water channels, the method of synthesis thereof, as well as the use thereof for desalination of brackish water and seawater, production of ultra-pure water or filtration of contaminants.

The present disclosure relates to a method of preparing a thin film composite layer immobilizing vesicles incorporating a transmembrane protein on a porous substrate membrane, comprising providing an aqueous solution comprising the vesicles and a di-amine or tri-amine compound, covering the surface of a porous support membrane with the aqueous solution, applying a hydrophobic solution comprising an acyl halide compound, and allowing the aqueous solution and the hydrophobic solution to perform an interfacial polymerization reaction to form the thin film composite layer.

A spiral wound membrane module is suitable for use with high temperature water that may also have a high pH, for example steam injection produced water. The module uses a membrane with a polyphenylene sulfide (PPS) backing material. The feed spacer of the module may be made from polyphenylene sulfide (PPS) or ethylene chlorotrifluoroethylene (ECTFE). The permeate carrier may be made of a woven nylon (i.e. nylon 6, 6) fabric coated with high temperature epoxy. The core tube and anti-telescoping device may be made of polysulfone. In some examples, the module may be used at a temperature of up to 130° C. Optionally, the module may be used at a pH of 9.5 or more. In a filtration method, the module may be operated at a pressure in the range of 150 to 450 psi. The module may be operated at a generally constant pressure.

A spiral wound membrane module is suitable for use with high temperature water that may also have a high pH, for example steam injection produced water. The module uses a membrane with a polyphenylene sulfide (PPS) backing material. The feed spacer of the module may be made from polyphenylene sulfide (PPS) or ethylene chlorotrifluoroethylene (ECTFE). The permeate carrier may be made of a woven nylon (i.e. nylon 6, 6) fabric coated with high temperature epoxy. The core tube and anti-telescoping device may be made of polysulfone. In some examples, the module may be used at a temperature of up to 130° C. Optionally, the module may be used at a pH of 9.5 or more. In a filtration method, the module may be operated at a pressure in the range of 150 to 450 psi. The module may be operated at a generally constant pressure.

Provided herein are methods of performing viral filtration on a fluid including a recombinant antibody, and the use of these methods in methods of manufacturing or producing the recombinant antibody.

Provided herein are methods of performing viral filtration on a fluid including a recombinant antibody, and the use of these methods in methods of manufacturing or producing the recombinant antibody.

The present disclosure provides, in some embodiments, devices, methods, and kits for purifying extracellular vesicles (EVs) using size exclusion chromatography in tandem with cation exchange chromatography, which can be referred to as dual-mode chromatography (DMC).

The present disclosure provides, in some embodiments, devices, methods, and kits for purifying extracellular vesicles (EVs) using size exclusion chromatography in tandem with cation exchange chromatography, which can be referred to as dual-mode chromatography (DMC).

A heat exchanger for a blood circulation circuit includes a hollow fiber membrane layer having a plurality of laminated hollow fiber membranes 31. Each of the hollow fiber membranes 31 has a barrier layer 5 having a hydrogen peroxide barrier property, and the barrier layer 5 has an oxygen permeability coefficient of 6 cc.Math.cm/m.sup.2.Math.24 h/atm or less at 25° C.

Lactic acid is obtained by a method including (A) a step of continuous fermentation wherein a fermentation culture medium of a microorganism having an ability of lactic acid fermentation is filtered through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm with a transmembrane pressure difference within the range of 0.1 to 20 kPa, and the permeate is collected, while retaining the non-permeated liquid in or returning the non-permeated liquid to the culture, and adding a fermentation feedstock to the culture; (B) a step of filtering the permeate obtained in Step (A) through a nanofiltration membrane; and (C) a step of distilling the permeate obtained in Step (B) under a pressure of not less than 1 Pa and not more than atmospheric pressure, at 25° C. to 200° C. to recover lactic acid.