The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

Support and drainage materials, filter including the materials, and methods of use are disclosed.

A filter element may include and endcap, filter media extending from the endcap, and a sleeve disposed at least partially surrounding the filter media. The sleeve may include an outer surface including a plurality of protrusions and a plurality of openings may be formed through the sleeve. The protrusions may direct fluid to be filtered by the filter media along a path that allows particulates to exit the fluid prior to contacting the filter media.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

An improved solids interceptor and methods of using the same. The solids interceptor includes a tank having an inlet and at least one outlet, and an access opening on an upper end of the tank. A perforated basket is removably received within the tank via the access opening. When the basket is installed within the tank, wastewater entering the tank via the inlet flows into the basket, with the solid waste being collected in the basket and the liquid waste flowing out of the basket via the perforated screen. The basket and tank include an interlocking flange assembly that automatically axially aligns a basket inlet with an inlet pipe simply by inserting the basket into the tank. The basket is removable from the tank to easily clean out and discard solid waste accumulated in the basket.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.