The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

Support and drainage materials, filter including the materials, and methods of use are disclosed.

A filter assembly includes a housing with an inlet and an outlet. The filter assembly also includes a tubular filter element located downstream of the inlet and upstream of the outlet and a sleeve element surrounding and blocking at least a portion of the filter element.

The present invention relates to a filter arrangement (1) comprising: a chamber (12) comprising a chamber inlet for unfiltered liquid, a chamber outlet for filtered liquid and a wall arranged to keep the unfiltered liquid and the filtered liquid separated, a filter element (2) having a longitudinal extension arranged inside of said chamber (12), wherein said filter element (2) comprises a semi-permeable filtration wall (22) comprising a folded filter (24) arranged in a zig-zag configuration between an inner perforated cylinder (26) and an outer perforated cylinder (28) and an internally located back- washing arrangement (3). The back-washing arrangement (3) comprises: an elongated and hollow body (32) having a longitudinal extension, which is substantially parallel to the longitudinal extension of the filter element (2), a mechanism configured to drive said body (32) in a rotational and/or an axial movement, a plurality of nozzles (34) arranged in fluid communication with a cavity inside of said body (32), said plurality of nozzles (34) projecting laterally from said body (32) such that a distal end (36) of each of said plurality of nozzles (34) is arranged in close proximity to said inner perforated cylinder (26) and an outlet (320) arranged in fluid communication with said cavity of said elongated and hollow body and wherein said plurality of nozzles (34) are arranged parallel to each other along a straight line on said body (32) such that they all project in the same direction.

A filter housing can be configured to receive a filter media to form a filter assembly. Water filter media assemblies can be adapted for filter-as-you-pour filtration in the context of container (e.g., pitcher) systems where filtering is achieved as the user pours water from the container. The filter housing can have a frame and an optional casing securable about the frame. The filter assembly can include a filter media within, connected to, or associated with a filter housing. The filter media can be securable in an at least partially curved configuration and/or within, connected to, or associated with the filter housing.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

Support and drainage materials, filter including the materials, and methods of use are disclosed.

Support and drainage materials, filter including the materials, and methods of use are disclosed.

Support and drainage materials, filter including the materials, and methods of use are disclosed.

Support and drainage materials, filter including the materials, and methods of use are disclosed.