An implantable vein frame is contemplated in which two ring members are rigidly joined in spaced axial alignment via one or more interconnecting members. One of the one or more interconnecting members defines a protruding region that acts upon the implant placed within the frame and/or the vein that the vein frame is placed within to define a sinus region. The implant is placed within and scaffolded by the vein frame, and the vein frame is subsequently inserted within a vein via a venotomy, or interposed between two vein segments via vein interposition graft. The vein frame acts to support the structural integrity of the implant, and to scaffold and anchor the implant in place with the vein.

An implantable prosthetic device such as might be used to treat poor function of a diseased heart valve in a medical patient includes a body portion and an anchor portion including a plurality of paddles. Clasps attached to the paddles include fixed arms and moveable arms operable to secure the device to the patient's native valve leaflets.

An actuator sleeve includes resiliency features that may reduce chronic strain on valve annulus implants. The resiliency features may relate to one or more of a material, a manufacture, a dimension, and/or design attribute of the sleeve. In one aspect the resiliency features may allow deformation of the sleeve at frame interfaces to distribute forces to reduce the frame fatigue.

A stent, a stent delivery system, and a method of delivering a stent are described that allow the porosity of the stent to be changed dynamically during a delivery procedure. Unlike prior stents and procedures that are configured to deploy with a predetermined porosity, the physician can create a region of high stent porosity over certain vessel features, a low stent porosity over other vessel features, and can create these porosity changes with at least one stent or stent layer.

Described is a prosthesis for implantation beneath the skin of a subject, the prosthesis comprising a support structure of super elastic material (e.g., nitinol), wherein the support structure is sized and shaped for augmenting, replacing, or reconstructing tissue of the subject, such as the breast. In certain embodiments, the prosthesis further includes an elastomeric outer shell having a cavity therein, the outer shell being sized and shaped for augmenting or replacing, for example, breast tissue of the subject; wherein the support structure is disposed within the cavity of the elastomeric shell.

Bone anchors and bone anchor insertion systems are provided that enable smaller bone holes for inserting a bone anchor by eliminating the need for a cannula. Smaller bone holes may help reduce patient recovery times. The provided bone anchor includes two flexible wings extending from a base portion that splay away from the base portion's central axis at rest, though may be bent towards or away from the central axis in response to an applied force. The bone anchor includes a drive feature that enables an inserter to couple and decouple to the bone anchor. A surgeon may drive the bone anchor through a bone hole via the coupled inserter while the bone hole maintains the bone anchor in a compressed state, and may decouple the inserter when the bone anchor is properly positioned, thereby eliminating the need for a cannula.

The present disclosure relates to valve replacement devices that are foldable for catheter-based deployment to the site of implantation, as well as systems for the delivery of valve prostheses, including prostheses having the special characteristics of the disclosed valve replacement devices. The devices include highly effective adhering mechanisms for secure and enduring precision implantation. The adhering mechanisms may employ a unique sealing mechanism that includes a cuff that expands slowly whereby the device is not secured in place until the completion of the implantation procedure. The implanted device, optionally together with the cuff, prevents perivalvular leaks and incorporate an appropriate leaflet system for reliable functioning in situ.

Method of endovascular intervention in neurovascular anatomy of a patient including deploying an anchor of a tethering device in an anchoring vessel of a neurovascular anatomy, the anchor coupled to a tether extending proximally from the anchor. Method includes advancing a guide-sheath over the tether of the tethering device anchored in the anchoring vessel and attached to the tether, the guide-sheath includes at least one lumen and a distal opening from the lumen. Method includes advancing a treatment device through the lumen of the guide-sheath and out the distal opening from the at least one lumen and through an entrance of a target intracranial vessel, and deploying the treatment device at a treatment site within the target intracranial vessel without a combined therapy of two or more anti-platelet therapeutic agents during a pen-procedural period. Related systems, devices, and methods are disclosed.

Devices and methods for treating heart disease by increasing the pulmonary vascular compliance and thereby decreasing the right ventricular afterload are disclosed. Devices may include a means for reducing the cross-sectional area of the pulmonary artery during diastole and allowing the cross-sectional area to increase during systole.

The devices and methods of this disclosure relate to a heart valve prosthesis that is configured to be implanted within a native heart valve having a smaller perimeter annuli with a generally elliptical shape.