The application relates to a heart valve clamp, comprises a fixed arm mechanism, a clamping arm mechanism, and a driving mechanism. The fixed arm mechanism comprises a fixed arm body and at least two fixed arms, extending outward from the fixed arm body, and integrally formed with the fixed arm body. The clamping arm mechanism comprises a clamping arm body connected to a bottom of the fixed arm body, and at least two clamping arms extending outward from the clamping arm bodies and integrally formed with the clamping arm body; and the driving mechanism comprises a second driving assembly that drives the fixed arm and the clamping arm to open or close. The fixed arm mechanism and the clamping arm mechanism of the entire heart valve clamp respectively forms an integral form, which can avoid the risk of the fixed arm or the clamping arm being disengaged, the stability of the whole structure is better. The fixed arm and the clamping arm clamp the valve leaflets under three-dimensional ultrasound and angiography navigation, so that the regurgitation area is reduced, which is capable of treating mitral or tricuspid regurgitation while keeping heat beating.

A compliant scaffold incorporates a plurality of elongated apertures that form a geometric pattern enabling biaxial expansion or contraction. An elongated aperture has a pair of nodes located on opposing sides of the aperture and between a pair of antinodes located on the extended and opposing ends of the elongated aperture. A geometric pattern may have various geometric shapes, or tiles, between the plurality of apertures. The geometric tiles have a bounded perimeter formed by the plurality of elongated apertures. A substantial portion of the elongated apertures may be configured with the antinodes proximal to one of said pair of nodes of a separate elongated aperture; wherein the antinodes are closer to one of the pair of nodes than to any other antinode. This unique arrangement of the elongated apertures may be formed in biological material in vivo or ex vivo.

Reversibly deformable corneal implants for replacing excised corneal tissue, the implants including an optical portion and an anchoring portion having different mechanical properties from each other.

An implantable endoluminal prosthesis for use in the treatment of aneurysm involving branches is described, where at least one self-expandable braided framework extending along an axis is able to expand from a radially compressed state in a delivery configuration to a radially expanded state. The self-expandable braided framework includes a plurality of layers of wires made of biocompatible material forming a lattice with a plurality of wires of said layers; the wires being integrated in the mesh of at least one of the adjacent layers; the self-expandable braided framework including a lumen in a cylindrical form; characterized in that, in radially expanded state, a ratio of a thickness of a wall of the implantable endoluminal prosthesis in the radially expanded state to the diameter of wire being greater than 3.0; and the surface coverage ratio (SCR) of the braided framework is at least 30% and at most 50%.

A low profile implant, system and method of deployment includes a frame comprising an elongate body having ends that overlap to form an annular configuration of the frame. A circumference of the frame may be modified by varying an extent of the overlap between the ends of the elongate body. The elongate structure may extend through a sleeve of a number of respective anchor housings of the implant along a first axis, and anchors may be deployed through bores in the anchor housings along a second axis to secure the anchor housings to tissue. The implant may be deployed about and anchored to a valve annulus, and the circumference of the frame, and associated anchored tissue, may be adjusted to reconfigure the valve annulus.

This application relates to a stent inserted in an eustachian tube for treatment of eustachian tube dysfunction. In one aspect, the stent includes a pressure controller which blocks the eustachian tube and is opened/closed according to a pressure difference between front and rear portions thereof to control a pressure in the eustachian tube. The stent may also include a eustachian tube expansion portion which is connected to the pressure controller and has a hollow portion passed therein to make a fluid move in back and forth directions of the eustachian tube, and is inserted in the eustachian tube to expand the eustachian tube by transforming a shape thereof in a radial direction of the eustachian tube.

A prosthetic valve includes a frame and a flow control component. The frame has an aperture extending through the frame about a central axis. The flow control component is mounted within the aperture and is configured to permit blood flow in a first direction approximately parallel to the vertical axis from an inflow end to an outflow end of the flow control component and to block blood flow in a second direction, opposite the first direction. The frame has an expanded configuration with a first height along the central axis, a first lateral width along a lateral axis perpendicular to the central axis, and a first longitudinal length along a longitudinal axis perpendicular to the central axis and the lateral axis. The frame has a compressed configuration with a second height less than the first height and a second lateral width less than the first lateral width.

A compressible and expandable stent assembly for implantation in a body lumen such as a mitral valve, the stent assembly including at least one stent barrel that is shaped and sized so that it allows for normal operation of adjacent heart structures. One or more stent barrels can be included in the stent assembly, where one or more of the stent barrels can include a cylinder with a tapered edge.

A prosthetic assembly configured for endovascular placement within an aortic arch and method of use thereof. The prosthetic assembly includes a proximal aortic stent-graft prosthesis configured to be positioned within a proximal portion of the aortic arch adjacent to the brachiocephalic artery, a distal aortic stent-graft prosthesis configured to be positioned within a distal portion of the aortic arch adjacent to the left subclavian artery, a first branch stent-graft prosthesis configured to be positioned within the brachiocephalic artery and a second branch stent-graft prosthesis configured to be positioned in one of the left common carotid and the left subclavian artery. When deployed, a proximal end of the first branch stent-graft prosthesis is disposed within a lumen of the proximal aortic stent-graft prosthesis to proximally displace the ostium of the brachiocephalic artery. When deployed, a proximal end of the distal aortic stent-graft prosthesis is disposed within the distal end of the proximal aortic stent-graft prosthesis to form an overlap between the proximal and distal aortic stent-graft prostheses. The overlap is relatively increased by the first branch stent-graft prosthesis proximally displacing the ostium of the brachiocephalic artery.

A hybrid actuation device includes an artificial muscle, a first plate coupled to a second plate, and a shape memory alloy wire. The artificial muscle includes a housing, a first electrode and a second electrode, and a dielectric fluid. The housing includes a first film layer, a second film layer, an electrode region, and an expandable fluid region. The first electrode and the second electrode are each disposed in the electrode region of the housing. The dielectric fluid is disposed within the housing. The first plate and the second plate are positioned within the housing, the first plate positioned between the first film layer and the first electrode, and the second plate positioned between the second film layer and the second electrode. The shape memory alloy wire extends from the first plate to the second plate and through the dielectric fluid.