Methods and devices that prevent stasis in the LAA by either increasing the flow through the LAA or by closing off or sealing the LAA. Increasing the flow is accomplished through shunts, flow diverters, agitators, or by increasing the size of the ostium. Closing off the LAA is accomplished using seals or by cinching the LAA.

A method for implanting a heart valve assembly includes positioning a bottom portion of a seal against an aortic annulus of a patient. The heart valve assembly includes an inner frame comprising a graft covering housing a prosthetic heart valve, wherein the graft covering extends around the prosthetic heart valve for providing sealing to the heart valve, an outer frame formed from a metallic material and defining a gridded configuration, and being secured to the graft covering by a plurality of stitches, and a sealing material positioned externally to the outer frame for providing sealing between the outer frame and a patient's anatomical wall to prevent paravalvular leaks. The sealing material includes a plurality of radially extending fibers that extend outwardly of the outer frame. The graft covering is made of polyester, polytetrafluoroethylene, expanded polytetrafluoroethylene, or a polymer.

A transcatheter atrio-ventricular valve prosthesis for functional replacement of an atrio-ventricular valve in a connection channel, having a circumferential connection channel wall structure, between atrial and ventricular chambers of a heart, including an inner device to be disposed in the interior of the connection channel, the inner device having a circumferential support structure which is radially expandable and having a valve attached to the circumferential support structure, and an outer device to be disposed on the exterior of the connection channel, wherein the outer device at least partly extends around the inner device at a radial distance to the inner device, wherein the inner and outer devices form a securing mechanism for securing the circumferential connection channel wall structure therebetween.

Compliance control stitch patterns sewn or embroidered into biotextile or medical textile substrates impart reinforcing strength, and stretch resistance and control into such substrates. Compliance control stitch patterns may be customizable to particular patients, substrate implantation sites, particular degenerative or diseased conditions, or desired time frames. Substrates having compliance control stitch patterns sewn or embroidered into them may be used in tissue repair or tissue reconstruction applications.

The invention relates to a mesh support device (10) for supporting a breast implant (20), wherein the mesh support device (10) has a tubular shape. The invention relates further to a breast implant device for implantation in a human body, comprising a breast implant (20) and a mesh support device (10), in which the breast implant (20) is positioned, wherein the mesh support device (10) has a tubular shape. In accordance with the invention, a method for preparing a breast implant (20) for implantation in a human body is also disclosed.

A shunt comprises a central flow portion configured to fit at least partially within an opening in a tissue wall. The tissue wall is situated between a first anatomical chamber and a second anatomical chamber and the opening represents a blood flow path between the first anatomical chamber to the second anatomical chamber. The central flow portion is further configured to maintain the blood flow path from the first anatomical chamber to the second anatomical chamber, prevent in-growth of tissue within the opening, and expand in response to expansion of the tissue wall.

A heart valve assembly includes an inner frame comprising a graft covering housing a prosthetic heart valve, wherein the graft covering extends around the prosthetic heart valve for providing sealing to the heart valve, an outer frame formed from a metallic material and defining a gridded configuration, and being secured to the graft covering by a plurality of stitches, and a sealing material positioned externally to the outer frame for providing sealing between the outer frame and a patient's anatomical wall to prevent paravalvular leaks. The sealing material includes a plurality of radially extending fibers that extend outwardly of the outer frame. The graft covering is made of polyester, polytetrafluoroethylene, expanded polytetrafluoroethylene, or a polymer.

A transcatheter valve includes an outer seal made of outwardly extending fibers and is configured for transfemoral delivery within a patient.

Embodiments relate to the use of auxetic geometries to construct the pores of membranes. Auxetic geometries expand in the transverse direction when stretched along the longitudinal direction. This behavior is counterintuitive as most materials contract in the transverse direction when stretched longitudinally. A mesh with pores that are auxetic has the potential to overcome the primary limitation of most prolapse meshes—pore collapse with tensile loading.

In one aspect, the disclosure relates to free-standing artificial muscles having a polymeric core encased by an elastic spring. The polymeric core can be any two-way shape memory polymer including, but not limited to, a semicrystalline polymer (polybutadiene polymer, a polycaprolactone polymer, a poly(ethylene-co-vinyl acetate)), a rubber, an ionomer, an elastomer, or a gel. In some aspects, the shape memory polymers are crosslinked. In an alternative aspect, the polymeric core is a twisted and coiled polymeric fiber. In other aspects, the polymeric core is reprocessable, remoldable, and/or recyclable. In one aspect, the elastic spring is metallic, ceramic, plastic, or any combination thereof. The stiffnesses or spring rate of the elastic spring and polymeric core, the two-way shape memory effect of the polymeric core, and their geometrical dimensions can be optimized to maximize the actuation strain based on theoretical principles described herein. Also disclosed are devices incorporating the free-standing artificial muscles.