A transcatheter valve assembly replacement device includes an improved paravalvular seal.

The abstract has been amended to the following: “A heart valve replacement device for endovascular repair is provided. The heart valve replacement device includes a plurality of fibers for creating a seal with an anatomy of the patient. A heart valve carried by an inner graft covering. The plurality of fibers form an outer seal for preventing paravalvular leaks between the replacement heart valve and the native valve of a patient.”

Soft tissue grafts, packaged soft tissue grafts, and methods of making and using soft tissue grafts are disclosed. One soft tissue graft includes processed tissue material having first and second opposed surfaces. The first and second opposed surfaces are bounded by first and second edges. The first edge has a concave shape that curves toward the second edge. The second edge has a convex shape that curves away from the first edge. The first surface comprises a plurality of apertures. At least one of the apertures is formed from a multi-directional separation in the first surface. One method of making a soft tissue graft includes positioning a cutting die on a surface of tissue material, pressing the cutting die into the tissue material to cut the tissue material, and processing the cut tissue material to create processed tissue material.

A device includes an elastic tubular stent including struts forming closed cells arranged in rows along a circumferential direction of the stent, with each cell having a first obtuse-angled corner on one end of the cell along a longitudinal direction of the stent and a second obtuse-angled corner on an opposing end of the cell along the longitudinal direction. The stent may be fabricated by cutting an array of quadrilateral cells in a nitinol hypotube to form a stent, with each cell having four corners with approximately equal angles. The stent may then be expanded radially such that each cell has a first obtuse-angled corner on one end of the cell along a longitudinal direction of the stent and a second obtuse-angled corner on an opposing end of the cell along the longitudinal direction, and heat treated to fix the shape of the stent.

Various aspects of the present disclosure are apparatuses, systems and methods for altering blood flow in a vessel of a patient. The apparatuses, systems and methods may include restricting blood flow within a first side branch vessel to reduce flow into the first side branch and increase flow into one or more arteries distal to the first side branch vessel.

A transcatheter valve assembly replacement device includes a paravalvular seal that includes outwardly extending fibers that create a seal with the annulus when the valve assembly is deployed.

A prosthetic implant with improved properties, suitable for implantation to the human body, comprising a composite comprising a base material and a plurality of additives, wherein the additives are selected from radiolucent additives and/or hyperechoic additives; or wherein the additives are selected to reduce the solvent concentration by between 5%-95%; or wherein the additives are selected to increase the elastic modulus by more than 20%; or wherein the additives are selected for combining these effects.

A prosthetic heart valve includes a valve frame (2), on which a plurality of valve leaflets (8) are fixed, and a fastening area for fastening in a blood vessel, which axially adjoins the valve frame (2). A stabilizing ring (14) is arranged in the fastening area. The stabilizing ring (14) defines a predetermined shape and a predetermined diameter of the fastening area and has at least one predetermined expansion point (22), whereby it is possible to expand the stabilizing ring (14) by an action of radial force on an inner circumference.

A stent-graft assembly is provided for a variety of medical treatments. The stent-graft assembly includes a stent disposed to and attached between an inner layer of graft material and an outer layer of graft material. One of both of the graft layers includes one or more of a depression, dimple or detent that increases the localized surface area of the graft in one or more portions of the stent otherwise susceptible to graft stretching in the absence of the depression, dimple or detent. There is also described a method of forming dimples in selective locations on one or port graft layers in one or more locations relative to a portion of the stent where a portion of the graft may be susceptible to stretching or tearing during crimping or loading operations.

A tubular seal includes an outflow end region and an inflow end region. The inflow end region is a portion of a polymeric web retaining a woven fabric, wherein the woven fabric has a non-linear edge defining an interface between the inflow end region and the outflow end region.