Compliance control stitch patterns sewn or embroidered into biotextile or medical textile substrates impart reinforcing strength, and stretch resistance and control into such substrates. Compliance control stitch patterns may be customizable to particular patients, substrate implantation sites, particular degenerative or diseased conditions, or desired time frames. Substrates having compliance control stitch patterns sewn or embroidered into them may be used in tissue repair or tissue reconstruction applications.

Methods and devices that prevent stasis in the LAA by either increasing the flow through the LAA or by closing off or sealing the LAA. Increasing the flow is accomplished through shunts, flow diverters, agitators, or by increasing the size of the ostium. Closing off the LAA is accomplished using seals or by cinching the LAA.

Concepts disclosed relate to multi-frame prosthetic valves including leaflet and anchor frame subcomponents, where the leaflet frame subcomponent does not directly couple with patient anatomy and is separated from the anchor frame subcomponent by a gap/space. An optional connecting sheath may be provided to interconnect the subcomponents and assist with prosthetic valve delivery and deployment. One or more bridging members, or annular groove covers, are provided to bridge and cover gap or space between the anchor frame subcomponent and leaflet frame subcomponent, such as at the inflow and/or outflow ends of the subcomponents. Such bridging/cover features may provide smoother flow profiles, reduce incidence of complications, facilitate perfusion during delivery, assist with device nesting during delivery, assist with relative subcomponent positioning following delivery, or provide any of a variety of additional or alternative functions and advantages.

A transcatheter valve assembly replacement device includes an improved paravalvular seal.

A growth-accommodating prosthetic valve system that can accommodate a patient's growth over time. The system features an expandable stent that can expand from a contracted configuration to an expanded configuration and leaflets attached to the scaffold that is sewn along a path such that the length of the path stays generally the same as the scaffold moves from the contracted configuration to the expanded configuration.

A stent according to the invention includes: a strut extending in a predetermined direction; a first protrusion provided on the strut, the first protrusion being substantially L-shaped and extending in a direction away from the strut and in a direction toward a distal side in the predetermined direction; a second protrusion that is provided on the strut and located distal to the first protrusion, the second protrusion being substantially L-shaped, extending in a direction away from the strut and in a direction toward a proximal side in the predetermined direction, and having a tip spaced apart from a tip of the first protrusion; and an opaque member being substantially tubular and highly opaque to radiation, the opaque member having two end portions in which the first and second protrusions are inserted, respectively.

A stent for aorta is formed by weaving at least two types of filaments having different diameters, such as a first filament and a second filament. The stent is configured to be at least partially compressible and extensible along the axial direction of the stent in a natural release state, wherein the first filament has a diameter of 20-150 μm, and the second filament has a diameter of 150-800 μm. When the stent is used in the treatment of aortic aneurysm and/or aortic dissection lesions, due to the axial compressibility and extensibility of the stent, low liquid permeability and strong radial support force are provided where needed in the aorta, and due to the axial stretchability thereof, the stent can be easily assembled to a delivery system having an appropriate diameter. Also provided are a stent kit comprising the stent and a stent delivery system.

Disclosed in the present invention are a stent apparatus having a self-pleated skirt, a processing method therefor, a skirt pleating method, and a cardiac valve. The stent apparatus comprises a stent, and is further provided with a flexible skirt. The skirt comprises: an unfolded state, where the skirt extends axially and surrounds the periphery of the stent before release; and a stacked state, where the skirt is driven by deformation during release of the stent, and gathers and is stacked along an axial direction of the released stent to form an annular perivalvular leakage blocking part. The stent apparatus is further provided with a pull-wire which is merely threaded on the skirt, and the pull-wire may react to the radial deformation during the release of the stent to drive the skirt to enter the stacked state. According to the present invention, based on perivalvular leakage prevention technology, an interventional stent is fitted with the lining of the blood vessels, so that the stent will not easily be migrated and is more stable, the scope of the applicable population is expanded, additional surgical risks are lowered, and perivalvular leakage, thrombi and other complications are prevented. Better hemodynamic performance is provided, the coverage function of endothelial cells of the host is enhanced, the probability of occurrence of endocarditis is lowered, and the normal blood supply function of the heart and blood vessels is recovered.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

A meshed, dehydrated, placental tissue allograft that can be used in the treatment of wounds. Specifically, the meshed allograft has the property of being able to be expanded to cover an irregularly shaped wound, therefore reducing the need to apply multiple, uniform sized grafts to a single wound site. The meshed, dehydrated placental tissue allograft is sourced from a human donor, and is then processed to remove any potential contaminants or microbes prior to applying a specific mesh pattern to the tissue. The meshed, dehydrated, placental tissue graft is reconstituted prior to applying to the subject, and can then be configured to optimally cover the shape of the wound site.