The present invention provides an artificial skin and a preparation method thereof. The present invention takes the xenogeneic acellular dermal matrix particles as main materials, and obtains the dermis layer by three-dimensional printing technologies, and then obtains the artificial skin by combining the epidermis layer with the dermis layer. The dermis layer of artificial skin in present invention has three-dimensional porous structure, which retains main components of natural dermal matrix in composition, and imitates distributed structure at fiber bundle diameter and pore size of natural dermal matrix in structure. This kind of novel biomimetic dermal scaffolds have obvious advantages in inducing migration and regeneration of skin cells, accelerating vascularization, promoting wound healing and improving healing quality. The dermis layer of artificial skin in present invention is obtained by three-dimensional printing technologies, which has precise and controllable structure, simple preparation method and high products qualification rate.

A branch vessel stent comprising a stent body and a first developing member, wherein the first developing member comprises a first developing portion and a second developing portion. A length of the first developing portion and a length of the second developing portion in an axial direction of the stent body are both not less than 0.5 mm. A distance between the intersections of the first developing portion and the second developing portion on a plane perpendicular to the axial direction of the stent body gradually increases from a position where the distance is the minimum distance to an end that is away from a first end of the first developing portion or the second developing portion. The minimum distance between the intersections of the first developing portion and the second developing portion on a plane perpendicular to the axial direction of the stent body is not more than 2 mm. The branch vessel stent is capable of accurately positioning the position thereof, and is capable of identifying a distortion and knotting of the stent for the branch vessel.

Embodiments herein relate to an implant for insertion into a patient. The implant comprises a plurality of unit cells arranged to form a three-dimensional lattice structure, the three-dimensional structure comprising a resting volume of the implant. The plurality of unit cells are arranged to form a porous network of the three-dimensional structure, and wherein the three-dimensional structure is a reversibly compressible three-dimensional structure, wherein a bulk porosity of the three-dimensional structure of the implant is at least 50%. Also disclosed is a method of tissue reconstruction or tissue augmentation. The method comprises implanting into the body of a subject an implant of the disclosure.

A coiled anchor is positioned at a mitral valve by extending and deflecting a catheter such that a distal end portion of the catheter has a curved shape that is disposed in a left atrium and a distal end of the catheter is positioned near a commissure of the mitral valve. A ventricular portion of the coiled anchor is advanced from the catheter under the mitral valve at the commissure and into a left ventricle. An atrial portion of the coiled anchor is deployed in the left atrium by retracting the catheter off the atrial portion of the coiled anchor while maintaining the position of the ventricular portion of the coiled anchor in the left ventricle.

A covered stent includes a tubular main stent and a connection stent disposed on the main stent. An opening is formed in a side wall of the main stent. The connection stent includes a fixed segment connected to the side wall of the main stent and a free segment connected to the fixed segment. Each of the fixed segment and the free segment further includes a stent and a coating covering the surface of the stent. One end of the free segment distant from the fixed segment is connected to the edge of the opening, and a gap is formed between one side of the free segment near to the side wall of the main stent and the side wall of the main stent. This stent can effectively resolve the problem of the limitation of an adjusted angle at a connection segment of an external connection stent and has better flexibility.

A device having a structured coating for adhering to rough, in particular, biological surfaces, includes a carrier layer, wherein a plurality of protrusions is arranged on the carrier layer, which protrusions each comprise at least one stem having an end face pointing away from the surface, and wherein a further layer is arranged at least on the end face, wherein the layer has a lower modulus of elasticity and is in the form of a film that interconnects the protrusions. The film can also be in the form of a removable film.

A double-layer lumen stent (100) includes a main body lumen stent (10) and an outer-layer skirt stent (20) surrounding an outer wall of the main body lumen stent (10); the outer-layer skirt stent (20) includes a support structure (21) and a cover layer (22) arranged on the support structure (21); one end of the outer-layer skirt stent (20) is connected to the outer wall of the main body lumen stent (10); the other end of the outer-layer skirt stent (20) is an opening structure (24) composed of the support structure (21); and the cover layer (22) is formed into an oblique cut shape at an edge of the opening structure (24). In the double-layer lumen stent (100), when a clinician releases the double-layer lumen stent (100) at a human tissue such as a vessel through a delivery device, constraint from the cover layer (22) to the opening structure (24) of the outer-layer skirt stent (20) can be reduced, and the adhesion between the cover layer (22) at the opening structure (24) on the outer-layer skirt stent (20) and the main body lumen stent (10) is reduced, thereby reducing release resistance to the outer-layer skirt stent (20) during the release process of the double-layer lumen stent (100).

An implant is produced by fabricating first and second layers. The first layer of repeated and truncated building units is fused together to define pores. The second layer of repeated and truncated building units are fused together to define pores and fused onto the first layer of truncated building units. The first and the second layers form at least part of a porous portion of the implant. The formed porous portion is attached onto a base portion of an implant. The truncated building units of each of the first and the second layers are in the form of spatially overlapping three-dimensional shapes.

A lightweight reinforced mesh, such as a surgical mesh, suitable for use in various applications, including breast reconstruction, cosmetic breast surgery, mastopexy, breast augmentation, breast reduction, soft tissue reconstruction, hernia repair, tissue plication reinforcement, tissue support and repair, tendon support and repair, tissue engineering, and procedures or other applications requiring additional soft tissue strength or thickness. In addition, disclosed is a use of such a mesh for tissue engineering, regardless of the surgical application. In particular, the present disclosure relates to a surgical mesh capable of providing enhanced support while maintaining flexibility, low density, and absorbable characteristics. Further the present disclosure, focuses on reducing the material burden of a scaffold while increasing void space to facilitate tissue ingrowth.

A tubular construct that includes a braided tube embedded therein is disclosed herein. The braided tube may be embedded between layers of the tubular construct or may alternatively be positioned flush with the inside of the tubular construct. The tubular construct is resistant to kinking and has enhanced radial strength. The braided tube reinforces the wall of the tubular construct by improving burst pressure resistance, tube strength, and torque transmission. When radial pressure is applied to the braided tube that is embedded in the construct, the braided tube cannot expand lengthwise. Thus, the compression strength of the construct is increased in the radial direction. This feature takes advantage of the same principle used in the children's toy colloquially known as a Chinese finger trap. The increased radial strength of the tubular construct prevents the construct from collapsing and thereby enhances its structural integrity.