A Light Adjustable Lens (LAL) Tracker comprises an Imaging System, for creating a LAL image by imaging a LAL implanted into an eye; and an Image Recognition System, coupled to the Imaging System, for determining a disk cross-correlator with the LAL image; determining an edge cross-correlator with the LAL image; and determining a LAL position by determining a combined cross-correlator from the disk cross-correlator and the edge cross-correlator. A Tracking-based Illumination Control System comprises the LAL Tracker for tracking a LAL implanted in an eye, including an Imaging System, and an Image Recognition System; and an Illumination Controller, coupled to the LAL Tracker, configured for determining a LAL misalignment factor, corresponding to a LAL misalignment that characterizes a misalignment of the LAL position with a LAL illumination pattern, and generating an illumination control signal in relation to the determined LAL misalignment factor.

A method and prosthesis is provided for percutaneous repair of an anatomical defect, such as an inguinal hernia. The method involves percutaneously accessing the inguinal canal of a patient. Following hernia reduction, if required, the hernia defect may be accessed and repaired percutaneously from within the inguinal canal. An implantable prosthesis may be percutaneously delivered into the inguinal canal. The prosthesis may be advanced along the inguinal canal from the percutaneous entry location to the defect site, where it may be deployed over and/or within the defect. A biocompatible foam material may be percutaneously delivered into the inguinal canal to reduce and/or repair the hernia defect. The foam may fill and solidify in the canal to prevent abdominal viscera from reentering the canal. Ablative therapy may be performed within the inguinal canal to cause a fibrotic response resulting in scar tissue formation and/or tissue shrinkage that narrows the canal.

Methods and compositions are provided for inducing phagocytosis of a target cell, treating an individual having cancer, treating an individual having an intracellular pathogen infection (e.g., a chronic infection), and/or reducing the number of inflicted cells (e.g., cancer cells, cells infected with an intracellular pathogen, etc.) in an individual. Methods and compositions are also provided for predicting whether an individual is resistant (or susceptible) to treatment with an anti-CD47/SIRPA agent. In some cases, the subject methods and compositions include an anti-MHC Class I/LILRB1 agent. In some cases, the subject methods and compositions include an anti-MHC Class I/LILRB1 agent and an anti-CD47/SIRPA agent (e.g., co-administration of an anti-MHC Class I/LILRB1 agent and an anti-CD47/SIRPA agent). Kits are also provided for practicing the methods of the disclosure.

A fenestrated endoprosthesis for the correction of aortic arch aneurysms comprising: a stent (20) having a first oblong lateral hole (23) having an area equal to the total area occupied by the innominate artery (11) and by the carotid artery (12); said stent (20) comprises a metal skeleton (21) covered with a fabric (22); characterized by comprising a flexible sac (30) that covers said stent (20) covered with fabric (22); said sac (30) comprises a second lateral hole (32) having an area larger than said first hole (23), so that the edges (26) of said stent (20) covered with fabric (22) that delimit said first hole (23) are visible; the edges (33) of said sac (30) that delimit the hole (32) are welded to said stent (20) covered with fabric (22); a volume (31) is created between said stent (20) covered with fabric (22) and said sac (30); said volume (31) is filled with a polymer.

A method of treating an aortic aneurysm of a patient with an endovascular graft system and mitigating post implant syndrome associated therewith comprises placing at least one prosthesis across an aneurysmal space. The prosthesis comprises a double-walled filling structure and a stent-graft. The stent graft is radially expanded at a first pressure and the filing structure is filled with a first filing agent to contact a thrombus in the aortic aneurysmal space. After the first filling agent is removed, the filling structure is filled with a second filling agent to contact the thrombus. Next the stent-graft is expanded at a second pressure causing the filing structure to place an effective amount of pressure on the thrombus and substantially mitigating the effects of post implant syndrome associated with the prosthesis.

Embodiments of a modulable absorption light adjustable lens (MALAL) comprise a light adjustable lens that is capable of changing its optical properties upon an adjusting irradiation, including a photo-modifiable material; and a modulable absorption front protection layer, including a modulable absorption compound whose absorption properties can be modulated with a modulating stimulus. Other embodiments include a method of adjusting an optical property of a modulable absorption light adjustable lens, the method comprising: reducing an absorption of a modulable absorption compound of a modulable absorption front protection layer of the MALAL by a modulating stimulus, the MALAL having been previously implanted into an eye; and changing an optical property of a light adjustable lens of the MALAL by applying an adjusting irradiation.

In a representative embodiment, a method comprises implanting first and second inflatable bodies within an annulus of a native heart valve by securing the inflatable bodies to tissue of the native heart valve with sutures, and implanting a prosthetic heart valve between the inflatable bodies such that the prosthetic heart valve is retained within the annulus by the inflatable bodies.

A system for treating an aneurysm comprises an elongate flexible shaft and an expandable member. An expandable scaffold is disposed over the expandable member and may be expanded from a collapsed configuration to an expanded configuration. A double-walled filling structure is disposed over the scaffold and has an outer wall and an inner wall. The filling structure is adapted to be filled with a hardenable fluid filing medium so that the outer wall conforms to an inside surface of the aneurysm and the inner wall forms a substantially tubular lumen to provide a path for blood flow. In the expanded configuration the scaffold engages the inner wall of the filling structure. A tether is releasably coupled with the filling structure and the flexible shaft thereby constraining axial movement of the structures relative to each other.

An implantable prosthesis and a method of attaching the prosthesis to a tissue structure disclosed. The prosthesis includes a body having a first side arranged to face the tissue structure having a defect and second side opposite the first side. One or more adhesive-filled pods are disposed on the first side of the body and selectively openable to supply an adhesive in between the tissue structure and the first side of the prosthesis body after the prosthesis body is positioned relative to the defect. The pods may be pierced, punctured, broken, and/or ruptured to supply the adhesive. A deployment device having a piercer may be used to puncture the pods.

A device for adjusting a shape of a coronary sinus in a heart of a patient, the device comprising a flexible tube having: an outer wall extending between a proximal end and a distal end; a first bore extending from the proximal end to the distal end; a proximal flange attached to the proximal end; a distal flange attached to the distal end; wherein, the outer wall includes at least one accordion-like hinge region.