A prosthetic heart valve includes (a) a stent body including a generally tubular annulus region having a tubular wall and a proximal-to-distal axis, the stent body having a radially expanded condition when the stent body is implanted, (b one or more prosthetic valve elements mounted to the stent body and operative to allow blood flow in a distal direction through the annulus region but to substantially block blood flow in a proximal direction through the annulus region, (c) a cuff coupled to the stent body, and (d) one or more biasing elements connected to the stent body and to the cuff, the biasing elements being adapted to bias at least a portion of the cuff outwardly with respect to the stent body.

The present disclosure provides meshed acellular dermal tissue matrix compositions, devices, and methods of use. The meshed devices can be used in conjunction with a variety of implants such as breast implants or tissue expanders.

An adhesive-applicator, and an implant that includes a wall formed from a porous fabric, are transcatheterally advanced to a heart of a subject. While a nozzle of the adhesive-applicator is disposed within an interior of the implant, the external surface of the wall is adhered to tissue of the heart by using the adhesive-applicator to apply an adhesive via the nozzle to the interior, such that a portion of the adhesive passes through the porous fabric of the wall to the external surface. Other embodiments are also described.

A valve repair device includes a pair of anchors and at least one leak inhibitor. The device can also include a spacer or coaptation element. The pair of anchors can be coupled to the spacer or coaptation element. The pair of anchors are movable between an open position and a closed position and are configured to attach the valve repair device to the native valve of the patient. The at least one leak inhibitor extends between the pair of anchors and is configured to inhibit retrograde blood flow through the device, for example, between one or more openings between leaflet portions that are in the anchors.

A surgical device for performing a repair of lacerated or ruptured tendons is disclosed. The surgical device comprises a tip or first end, a base or second end opposite to the first end, and a length between the first and second end configured to pass at least in part through a tendon sheath. The surgical device increases in diameter from the first end to the second end over at least a portion of the length. The second end is shaped to accommodate retracted proximal end of the damaged tendons. The second end is inserted into a flexor fibro-osseous tunnel configured to distend and enlarge its pathway. The second end is sutured to the retracted proximal end and towed via the fibro-osseous tunnel, thereby providing a gentle, guided, and non-traumatic passage of the flexor tendon and retrieving the retracted proximal end of the damaged flexor tendon simultaneously to the repair zone.

A prosthetic mitral valve includes an anchor assembly, an annular strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The annular strut frame is disposed radially within the anchor assembly. An atrial end of the annular strut frame is attached to the anchor assembly such that a ventricular end of the annular strut frame is spaced away from the anchor assembly.

A prosthesis secures a replacement valve in a heart. The prosthesis includes a radially expandable inflow section and outflow section, and migration blocker rods. The inflow section has a tapered shape and is implanted within an atrium of a heart adjacent a native valve annulus. The outflow section couples to the inflow section, and is configured to be implanted through the native valve annulus and at least partially within a ventricle of the heart. The migration blocker rods extend circumferentially around at least a portion of the outflow section and hold native leaflets of the heart valve. In a contracted configuration, the prosthesis may be implanted through a catheter into the heart. In an expanded configuration, the tapered shape of the inflow section in the atrium cooperates with the migration blockers in the ventricle to hold the prosthesis against the native valve annulus.

Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an anchoring member having an upstream portion configured to engage with tissue on or near the annulus of the native heart valve and to deform in a non-circular shape to conform to the tissue. The device can also include a mechanically isolated valve support coupled to the anchoring member and configured to support a prosthetic valve. The device can further include an atrial extension member extending radially outward from the upstream portion of the anchoring member and which is deformable without substantially deforming the anchoring member. In some embodiments, the upstream portion of the anchoring member and the extension member may be deformed while the valve support remains sufficiently stable.

Implantable devices formed of materials which are not readily imageable are delivered and deployed with a deployment/delivery device having one or more sensors generating a signal indicating a condition of the implantable device relative to the deployment site. For instance, the signal indicates at least one or more of the following: purchase of the implantable device with tissue, level of purchase of the implantable device with tissue, the position of the implantable device relative to the deployment site, seating of tissue with respect to the implantable device, extent of contact of the implantable device with tissue, or further information about the implantable device and/or the delivery/deployment device. As such, the implantable device need not be imaged to determine the relationship of the implantable device relative to the deployment site.

A prosthetic device for sealing a native heart valves to prevent or reduce regurgitation comprises a spacer having one or more anchors. The spacer may also have atrial support structures, ventricular support structures, or both atrial and ventricular support structures In some cases, the spacer has anchors that attach to the leaflets as well as atrial and ventricular support. In some cases, the spacer straddles the annulus and is located by anchors, and in some cases the support structures can be implanted within the native heart valve. In some cases, the prosthetic device reduces the annulus diameter when implanted within the native heart vasculature. In some cases, the prosthetic device cinches the annulus when implanted within the native heart vasculature.