Vascular endografts and methods of making and using the same are provided. The vascular endograft includes an elongated body defining a lumen configured to allow blood to flow therethrough and further defining an exterior surface, and a plurality of bristles extending outwardly from the exterior surface of the elongated body. In an instance in which the endograft is positioned within a blood vessel at a location corresponding to a blood vessel pathology, the bristles encourage positive remodeling of the blood vessel.

The present invention provides an artificial skin and a preparation method thereof. The present invention takes the xenogeneic acellular dermal matrix particles as main materials, and obtains the dermis layer by three-dimensional printing technologies, and then obtains the artificial skin by combining the epidermis layer with the dermis layer. The dermis layer of artificial skin in present invention has three-dimensional porous structure, which retains main components of natural dermal matrix in composition, and imitates distributed structure at fiber bundle diameter and pore size of natural dermal matrix in structure. This kind of novel biomimetic dermal scaffolds have obvious advantages in inducing migration and regeneration of skin cells, accelerating vascularization, promoting wound healing and improving healing quality. The dermis layer of artificial skin in present invention is obtained by three-dimensional printing technologies, which has precise and controllable structure, simple preparation method and high products qualification rate.

Embodiments herein relate to an implant for insertion into a patient. The implant comprises a plurality of unit cells arranged to form a three-dimensional lattice structure, the three-dimensional structure comprising a resting volume of the implant. The plurality of unit cells are arranged to form a porous network of the three-dimensional structure, and wherein the three-dimensional structure is a reversibly compressible three-dimensional structure, wherein a bulk porosity of the three-dimensional structure of the implant is at least 50%. Also disclosed is a method of tissue reconstruction or tissue augmentation. The method comprises implanting into the body of a subject an implant of the disclosure.

Compositions and methods for generating insulin-producing beta cells from pluripotent stem cells are provided. The compositions and methods of the present invention involve stepwise differentiation while the differentiating cells are cultured on a lung tissue-derived acellular scaffold.

The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises: a three-dimensionally warped and branched sheet (2) where (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume V.sub.E; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; iv) the three-dimensionally warped and branched sheet (2) has a volume V.sub.S; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); (vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2); and (viii) where the conduits (5) have (a) a mean diameter D.sub.C; and (b) an anisotropicity index of 1.01 to 5.00.

Apparatuses, systems and methods for providing improved ophthalmic lenses, particularly intraocular lenses (IOLs), include features for reducing dysphotopsia effects, such as haloes and glare. Exemplary ophthalmic lenses may include a central zone with a first set of two echelettes arranged around the optical axis, the first set having a profile in r-squared space. A middle zone includes a second set of two echelettes arranged around the optical axis, the second set having a profile in r-squared space that is different than the profile of the first set. A peripheral zone includes a third set of two echelettes arranged around the optical axis, the third set having a profile in r-squared space that is different than the profile of the first set and the profile of the second set, the third set being repeated in series on the peripheral zone.

The present disclosure provides a method for producing a multifunctional implantable structure, the method having: preparing an implantable base; coating a polymer layer on the base, wherein the polymer layer is partially curable; curing the polymer layer such that the polymer layer has cured and non-cured portions; and dry-etching the polymer layer to remove the non-cured portion thereof, to allow the polymer layer to have a nano-turf structure having pores defined therein.

A coronary stent is disclosed herein as having a lattice configuration on a generally thin-walled cylindrical tube. This particular stent is fabricated using an elongated thin-walled tubular solid that has a diameter equal to that of the final expanded configuration of the stent. In other words, the lattice configuration is cut onto the surface of the tubular solid that has a diameter substantially equal to the inner diameter of the blood vessel for which the stent is intended. The tubular lattice is then shrunk (collapsed) axisymmetrically to a new cylindrical configuration with a diameter substantially less than the blood vessel for which the stent is intended. The stent in its reduced diameter state can then be delivered to a desired site in the body via a catheter with an inflatable balloon at its distal portion. Upon the inflation of the balloon, the stent will assume its expanded, deployed configuration into the original diameter at the desired site in the body.

A device having a structured coating for adhering to rough, in particular, biological surfaces, includes a carrier layer, wherein a plurality of protrusions is arranged on the carrier layer, which protrusions each comprise at least one stem having an end face pointing away from the surface, and wherein a further layer is arranged at least on the end face, wherein the layer has a lower modulus of elasticity and is in the form of a film that interconnects the protrusions. The film can also be in the form of a removable film.

The present invention provides a jig for forming a dysphonia treatment tool, the jig being capable of bending a front piece in a position not through a hole. A jig 20C for forming a dysphonia treatment tool X by deformation, the dysphonia treatment tool X including: a plurality of clamping sections each having a front piece 1a disposed on a front surface of incised thyroid cartilage and a rear piece disposed on a rear surface of the thyroid cartilage, the clamping sections configured to be fit to respective cut ends of the thyroid cartilage facing each other; and a bridging section linking the clamping sections to each other, the front piece having a hole 3 formed therein, the forming jig includes a clip section 22 having a pair of maintaining sections 21a, 21b configured to sandwich the front piece 1a from both surfaces to cover at least a portion of the hole 3.