A method of preventing paravalvular leakage includes concurrent delivery of a heart valve prosthesis and an annular sealing component. During delivery, the sealing component is moved from a first position to a second position of the heart valve prosthesis which is longitudinally spaced apart from the first position of the heart valve prosthesis. The sealing component is secured around the heart valve prosthesis at the second position by a contoured outer surface of the heart valve prosthesis. The sealing component may be a flexible ring or may be a cylindrical flexible sleeve having a plurality of ribs longitudinally extending over the cylindrical sleeve. The ribs operate to deploy the sealing component such that at least a portion of the cylindrical sleeve buckles outwardly away from the outer surface of the heart valve prosthesis.

Methods, devices and systems for anchoring and/or sealing a heart valve prosthesis and, in particular, a mitral valve prosthesis (202). Inflatable elements (204, 206) are used to seal and anchor the mitral valve prosthesis (202) and/or other elements associated with repairing a native mitral valve.

The present invention relates to a medical chamber system (700) for implantation in the chest of a patient to support the heart activity, preferably by displacing the heart apex (105), comprising at least a first chamber (702) for arrangement inside the heart sac (300) and a second chamber (701) for arrangement outside the heart sac (300), wherein the chambers (701, 702) comprise at least one connection portion or connection channel (703) which connects the two chambers (701, 702) to each other, the chambers (701, 702) and the connection channel (703) are further embodied to be filled with fluid (705) and, preferably in the implanted state, to be arranged such that the heart activity acts on the first chamber (702) and that the second chamber (701) acts as a volume storage and/or energy storage for the fluid (705). Furthermore, the present invention relates to an introduction system for a medical chamber system (700) and to a kit, encompassing a medical chamber system (700) and an introduction system.

A system for treating an aneurysm comprises an elongate flexible shaft and an expandable member. An expandable scaffold is disposed over the expandable member and may be expanded from a collapsed configuration to an expanded configuration. A double-walled filling structure is disposed over the scaffold and has an outer wall and an inner wall. The filling structure is adapted to be filled with a hardenable fluid filing medium so that the outer wall conforms to an inside surface of the aneurysm and the inner wall forms a substantially tubular lumen to provide a path for blood flow. In the expanded configuration the scaffold engages the inner wall of the filling structure. A tether is releasably coupled with the filling structure and the flexible shaft thereby constraining axial movement of the structures relative to each other.

An intraocular lens (IOL) with a shape-changing optic is provided. The shape-changing optic includes an elastic anterior face located anterior to the equator. The anterior face has an anterior surface, a posterior surface, and a periphery. The shape-changing optic also includes a posterior face having an anterior surface, a posterior surface, and a periphery. An elastic side wall can extend across the equator and extend from the anterior face to the posterior face. A chamber can be located between the anterior face and the posterior face. The IOL can further include at least one haptic extending from the periphery of the anterior face, the periphery of the posterior face, or both.

An implant can be used for the treatment of fat pad atrophy. The implant can be installed in the ball of the foot, the heel of the foot, the hands, or other areas. The implant can supplement or replace a patient's fat pads. In some instances, the implant can include an implant pad having a non-permeable external lining and an internal cavity enclosed by the external lining. The internal cavity can include a filler material. The implant can include features that resist rupture and/or migration.

An intraocular lens (IOL) having an optical axis extending in an anterior-posterior direction and an equator extending in a plane substantially perpendicular to the optical axis is described. The IOL includes: an elastic anterior face located anterior to the equator; a posterior face located posterior to the equator, wherein the anterior face, the posterior face, or both comprises a poly(dimethylsiloxane) elastomer having a durometer between about 20 Shore A to about 50 Shore A; and a chamber located between the anterior face and the posterior face comprising a silicone oil comprising polysiloxanes comprising diphenyl siloxane and dimethyl siloxane units, the silicone oil having a maximum viscosity of about 800 cSt at 25° C.

A prosthetic assembly for repairing a target tissue defect within a target vessel region configured includes an exclusion structure sized to substantially bypass target tissue defect, and includes a branch assembly. The branch assembly can include a self-expanding outer branch prosthesis having an inflow region configured to deform to a non-circular cross-sectional-shape when deployed, and a support structure at least partially disposed within the inflow region. The support structure preserves blood flow to the branch vessel while the deformed inflow region inhibits blood leakage between and/or around the prosthetic assembly.

An apparatus for partially supporting a leaflet of a regurgitant heart valve includes at least one subvalvular device including a subvalvular supporting portion and an anchor portion. The subvalvular supporting portion and anchor portion are each at least partially formed from at least one of braided mesh strands of a first configuration, braided mesh strands of a second configuration, a balloon, a plurality of longitudinally extending struts, and a plurality of laterally extending struts. A connector neck is interposed longitudinally between, and is attached to both of, the subvalvular supporting portion and the anchor portion. The connector neck penetrates longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site.

Procedural methods are provided that are capable of forming a protuberant region, in which the surface of a living body protrudes, in a less-invasive manner and a medical device capable of forming the protuberant region in a less-invasive manner. A procedural method for forming a protuberant region, in which a surface of a living body protrudes, includes an introduction step of introducing a container having flexibility into the living body, a protuberant region forming step of forming the protuberant region, in which the surface of the living body protrudes, by filling the container with a filling material to expand the container, and a placement step of placing the expanded container in the living body.