An intraocular lens for providing a subject with vision at various distances includes an optic having a first surface with a first shape, an opposing second surface with a second shape, a multifocal refractive profile, and one or more diffractive portions. The optic may include at least one multifocal diffractive profile. In some embodiments, multifocal diffractive and the multifocal refractive profiles are disposed on different, distinct, or non-overlapping portions or apertures of the optic. Alternatively, portions of the multifocal diffractive profiles and the multifocal refractive profiles may overlap within a common aperture or zone of the optic.

Implantable in vivo sensors used to monitor physical, chemical or electrical parameters within a body. The in vivo sensors are integral with an implantable medical device and are responsive to externally or internally applied energy. Upon application of energy, the sensors undergo a phase change in at least part of the material of the device which is then detected external to the body by conventional techniques such as radiography, ultrasound imaging, magnetic resonance imaging, radio frequency imaging or the like. The in vivo sensors of the present invention may be employed to provide volumetric measurements, flow rate measurements, pressure measurements, electrical measurements, biochemical measurements, temperature, measurements, or measure the degree and type of deposits within the lumen of an endoluminal implant, such as a stent or other type of endoluminal conduit. The in vivo sensors may also be used therapeutically to modulate mechanical and/or physical properties of the endoluminal implant in response to the sensed or monitored parameter.

An implant that may maintain position with a Eustachian tube of a patient, the implant includes an engagement body, an anchoring assembly, and a pressure balance assembly. The engagement body includes an exterior surface dimensioned to bear radially outward against the Eustachian tube. The anchoring assembly may lock the implant in the Eustachian tube. The pressure balance assembly includes a vented pathway that may transition between an occluded state and a vented state. The vented pathway may provide fluid communication between the proximal end and the distal end of the implant in the ventilated state while inhibiting fluid communication between the proximal end and the distal end of the implant in the occluded state.

An endoluminal prosthesis including a radially expandable support member having interior and exterior surfaces and a wall with openings, a first covering member including a biocompatible polymer material at least partially positioned against the interior surface, and a second covering member including a biocompatible polymer material at least partially positioned against the exterior surface. The first covering member attaches to the second covering member at predetermined bonding locations within less than all of the openings thereby leaving unbonded regions.

In an artificial blood vessel of the present invention, the artificial blood vessel has a warp yarn 1 extending along the axial direction and a weft yarn 2 extending along the circumferential direction of the artificial blood vessel VE, and it has a structure in which the warp yarn 1 extends in a wavy shape when the artificial blood vessel VE is viewed in the radial direction such that positions of the warp yarn 1 at top parts Mt1, Mt2 of a pair of mountain parts M adjacent in the axial direction match in the circumferential direction and a position of the warp yarn 1 at a bottom part Vb of a valley part V between the pair of mountain parts M is offset in the circumferential direction relative to positions of the warp yarn 1 at the top parts Mt1, Mt2 of the pair of mountain parts M.

A device comprising a microstructured surface wherein in one aspect, the microstructured surface is arranged hierarchically with dual-functioning textured features. The surface may achieve adhesive properties by varying the parameters of the microstructure features. Additionally, the surface may achieve cellular and/or tissues in-growth functionality by varying the same parameters. Generally, the dual-functional aspect includes at least one surface feature having a varied periodicity which may be imposed on at least one other surface feature.

Certain aspects of the disclosure concern a device for repairing or replacing a native heart valve. The device can include a frame including a first set of struts intersecting with a second set of struts at a plurality of strut connection points. The frame can be radially expandable from a radially collapsed state to a radially expanded state. The device can include at least one expansion feature including a screw head and a screw shaft connected to the screw head. The screw shaft can extend through a first strut connection point and a second strut connection point. The device can further include a plurality of penetrating members extending from a first end of the frame. Rotating the screw shaft in a first direction can radially expand the frame from the radially collapsed state to the radially expanded state.

Various embodiments for a composite endovascular device (and variations thereof) that include an inner polymer structure and an outer thin-film shape memory structure. The inner polymer structure extends from a distal end to a proximal end along a longitudinal axis. The outer thin-film shape-memory structure has an inner thin-film surface coupled to the outer surface of the inner polymer structure from the distal end to the proximal end with a retrieval member at the proximal end to allow for the prosthesis to be retrieved after placement in a body vessel. The inner polymeric structure can be blended with a suitable bio-active agent or the agent can be loaded into the pores. The device can be permanent or temporary by virtue of being retrievable.

The intervertebral three-dimensional structure comprises a top side, an underside, a front face, a rear face, and a plurality of boreholes designed to receive affixation elements.

Described embodiments are directed toward prosthetic valves having leaflets that move asymmetrically in that a leaflet second side region of the leaflet initially moves toward the open position before a leaflet first side region and the leaflet first side region initially moves toward the closed position before the leaflet second side region. In the fully open position, the leaflet first side region opens less than the leaflet second side region. Asymmetric opening and final open position, in synchrony with the other leaflets having the same motion and final open position creates spiral flow exiting the open valve that increases blood flow on the downstream side of the leaflet and thus reduces stagnation of the blood that might lead to thrombus formation. Controlled asymmetric movement of the leaflet reduces closing volume by initiating closure on the leaflet first side region and finishing closures on the leaflet second side region.