The current invention is directed to a medical implant made of bulk-solidifying amorphous alloys and methods of making such medical implants, wherein the medical implants are biologically, mechanically, and morphologically compatible with the surrounding implanted region of the body.

A hearing protection system including an earplug moveably displaceable in a plane covering an ear of a user from an open position to a closed position in response to a signal received from a trigger mechanism. When in the open position, the earplug is positioned adjacent to the ear of the user to allow the user to hear ambient sound at an unchanged volume. When in the closed position, the earplug is positioned over the ear of the user to at least partly block the ambient sound and allow the user to hear the ambient sound at a reduced volume that is less than the unchanged volume.

Intraocular implants and methods of making intraocular implants are provided. The intraocular implants can improve the vision of a patient, such as by increasing the depth of focus of an eye of a patient. In particular, the intraocular implants can include a mask having an annular portion with a relatively low visible light transmission surrounding a relatively high transmission central portion such as a clear lens or aperture. This construct is adapted to provide an annular mask with a small aperture for light to pass through to the retina to increase depth of focus. The intraocular implant may have an optical power for refractive correction. The intraocular implant may be implanted in any location along the optical pathway in the eye, e.g., as an implant in the anterior or posterior chamber.

Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.

Provided is a stent that is placed in the bile duct to facilitate bile secretion into the duodenum. The stent includes an elastically deformable body, a film part, and an anti-inversion part. The body has a predetermined diameter and length and is formed by interlacing wires in the form of a tube. The film part surrounds to cover at least a portion of the body, extends a predetermined length from one end of the body, and is made of a flexible material. The anti-inversion part is connected to the one end of the body from which the film part extends and prevents the film part from being inverted and folded inwardly toward the body.

The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.

A stent system and method to prevent stent migration. The stent system includes a magnetic stent comprising an outer surface and an inner surface, a proximal end, and a distal end with three or more magnets disposed thereon and configured to form a ring. The system may further have a magnetic ring comprising three or more magnets configured to form a ring. The magnetic ring is disposed proximally or distally to the magnetic stent, which allows magnetic repulsion to maintain the position of the stent.

The present invention provides a preparation method preparation method for three-layer artificial blood vessel and application thereof. The three-layer artificial blood vessel comprise three layers, electrospinning inner layer, dense middle layer and electrospinning outer layer, the three-layer structure is closely combined and difficult to separate. The inner layer with a cytoskeleton-like structure can promote the formation of intima; the dense middle layer can effectively prevent the leakage of biomacromolecules and increase the puncture resistance of the whole artificial blood vessel; and the outer layer can promote the growth of tissue cells and better integrate with tissue. The three-layer artificial blood vessel provided by the invention has excellent blood compatibility, good flexibility, good puncture resistance and interlayer peeling resistance. The preparation method is convenient and is suitable for industrial scale production.

The invention relates to a method for producing a vascular endoprosthesis for insertion into a natural cavity of a person's body. The method is based on a three-dimensional model including a main channel, at least one branch of the channel extending from the main channel, and an intersection between the main channel and the branch of the channel. The method includes producing an imprint structure which is designed to follow a shape of the main channel, the imprint structure comprising at least one location corresponding to the intersection of the three-dimensional model, placing a reinforcement at the location of the imprint structure, producing a wall using the imprint structure, the prosthesis wall being made of polymer, a window or a branch of the prosthesis being produced at the location, producing the vascular endoprosthesis including the window or branch of the prosthesis.

The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.