A method of operating a membrane separation device in a continuous flow process includes in the membrane separation device, separating a supply liquid into a first partial stream and a second partial stream, wherein flow rate of the second partial stream and/or recovery rate of the second partial stream is influenced by at least one influencing variable that varies during operation, and varying the flow rate of the first partial stream to compensate for a change of the at least one influencing variable to control flow rate and/or recovery rate of the second partial stream to a preset value.

The present invention relates to a filtration device including: a flow rate control unit; a separation membrane module; a liquid flow rate detection unit detecting a liquid flow rate at a freely-selected part; and an external control unit controlling a state of the flow rate control unit, in which the external control unit includes: a target range setting step of setting a target flow rate range A; a control state recording step of recording a state S of the flow rate control unit when the liquid flow rate at the freely-selected part first enters within the target flow rate range A; a state setting step of setting the flow rate control unit to the state S; and a flow rate controlling step of controlling the liquid flow rate to be within the target flow rate range A.

Filtering systems, methods, and devices, particularly adapted for apheresis of cellular bodies and more specifically for apheresis of circulating tumor cell bodies (CTCs) employs a cross-flow channel. Systems and methods as well as devices for such a system are described. Embodiments include a cylindrical filter that employs a thin micro-machined porous filter membrane with a regular array of pores and reliably pass blood while trapping CTCs.

A water treatment system according to an embodiment of the present invention includes a tank that stores water to be treated, a crossflow filtration membrane module that filters the water to be treated, a supply passage through which the water to be treated is supplied from the tank to the filtration membrane module by using a supply pump, and a recirculation passage through which the water to be treated, the water having passed through a membrane upstream side of the filtration membrane module, is recirculated to the tank. The tank has an upper space above a liquid surface of the stored water to be treated, the upper space being hermetically filled with an inert gas. The water treatment system further includes a gas transport passage through which the inert gas is introduced from the upper space into the supply passage or the filtration membrane module, and a compressor that is disposed in the gas transport passage and that pressurizes the inert gas. The compressor is preferably a water-sealed compressor.

The present invention provides a method for preparing a composition comprising highly concentrated antibodies by ultrafiltration in batch concentration mode having a first constant feed rate step and a second controlled feed rate step.

The present invention provides a method for preparing a composition comprising highly concentrated antibodies by ultrafiltration in batch concentration mode having a first constant feed rate step and a second controlled feed rate step.

The present invention provides a method for preparing a composition comprising highly concentrated antibodies by ultrafiltration in batch concentration mode having a first constant feed rate step and a second controlled feed rate step.

The invention relates to an ultrafiltration unit for continuous buffer or medium exchange, a method for continuous buffer or medium exchange in the ultrafiltration unit, and a plant in particular for (semi)continuous production of biopharmaceutical and biological macromolecular products in particular, such as proteins, e.g. monoclonal antibodies and vaccines, comprising the ultrafiltration unit according to the invention.

Exemplary systems and methods are provided for receiving a feed flow at a feed flow inlet of a single pass tangential flow filtration unit, wherein the single pass tangential flow filtration unit includes one or more membranes or membrane devices in a one-or two-stage configuration, and wherein a pressure drop across the one or more membranes or membrane devices is less than or equal to 30 psi. The systems and methods are configured to separate, using the one or more membranes or membrane devices in a one-or two-stage configuration, the feed stream into a permeate stream and a retentate stream and output the permeate stream through one or more permeate outlets and the retentate stream through one or more retentate outlets.

A method for filtering a dairy product is used in a filter system that includes at least one pump loop having a pump and a filter, with the pump being arranged to feed a feed product to the filter for filtering the feed product and outputting a permeate product and a retentate product. The method includes supplying the feed product to the pump at a feed pressure, during a first operational mode in which the feed pressure is below a first predefined threshold, controlling the pump to operate at a first power that is within a first percentage range of a maximum rated power of the pump, and during a second operational mode in which the feed pressure is above the first predefined threshold, controlling the pump to operate within a second percentage range of the maximum rated power which is higher than the first percentage range.