The present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30 C. The disclosure also includes a process for preparing highly concentrated antibody compositions, and highly concentrated antibody products.

The present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30 C. The disclosure also includes a process for preparing highly concentrated antibody compositions, and highly concentrated antibody products.

A control system configured to control operation of reverse osmosis (RO) array(s), nanofiltration (NF) array(s) and/or a blending system including a control panel (CP), regulatory controllers (RCs), and a supervisory controller (SC), wherein the SC is in signal communication with the CP, and with the RCs, wherein the SC is configured to: receive user inputs from the CP, and receive inputs from RCs regarding data from sensors, wherein the RCs are in signal communication with the plurality of sensors, wherein the RCs are configured to: receive data from the sensors, provide outputs to and receive permissions from the SC, and instruct devices in response to the received permissions from the SC, and wherein the SC is configured to: monitor trends in the inputs regarding and/or predict outcomes from data received from the RCs and determine the permissions for RCs based on the monitored trends and/or user inputs from the CP.

A conditioning system for a filter module is disclosed. The conditioning system may generally include an inlet, a heat exchanger, a magnetically levitated pump, a channel provided to bypass the heat exchanger, a controller, an outlet, and a base. The system may have components lined with corrosion-resistant materials. A method of conditioning a filter module is also disclosed. The method may generally include measuring TOC in a source of ultrapure water, heating the ultrapure water, rinsing a filter module with the heated water, flushing the filter module with ambient temperature water, and repeating the rinsing with heated water and flushing with ambient temperature water. A method of facilitating conditioning of the filter module is also disclosed. The method may generally include providing a portable filter module conditioning system and providing instructions for installation or use.

A cleaning-in-place method for cleaning a membrane filter module, the membrane filter module including a membrane having a feed side and a permeate side and being configured to filter a fluid passing through the membrane from the feed side to the permeate side; wherein the method comprises performing a sequence of process cycles, the sequence comprising at least one monitored process cycle, the monitored process cycle comprising: providing a flow of a liquid through the membrane and/or across the feed side of the membrane; monitoring at least one hydraulic parameter associated with the provided flow of the liquid; and terminating the flow of the liquid, when the at least one monitored hydraulic parameter meets a predetermined cycle completion criterion.

A filtration system for a fuel cell hybrid propulsion system includes a first stage filter, a second stage filter positioned downstream of the first stage filter, and a third stage filter positioned downstream of the second stage filter and configured to be positioned upstream of a fuel cell system. The first stage filter has first pores with a first mean pore size. The second stage filter has second pores with a second mean pore size. The third stage filter has third pores with a third mean pore size. The second mean pore size is less than the first mean pore size. The third mean pore size is less than or equal to the second mean pore size. The first, second, and third stage filter are structured to filter an airflow prior to being received by the fuel cell system.

A method for controlling water purification, and a water purification apparatus (1). The apparatus (1) comprises a reverse osmosis membrane (3a) configured to receive feed water from a feed pump (5), and to produce permeate water and reject water. The method comprises measuring (S1) a property indicative of an inlet water quality C.sub.inlet of inlet water to the feed pump (5), and determining (S2) a target recovery for the water purification based on the property indicative of the inlet water quality. The method further comprises controlling (S3) a feed pump speed to a predetermined speed, or to a speed determined based on a relation between the feed pump speed, the inlet water quality C.sub.inlet and a target permeate water quality C.sub.per, based on the inlet water quality. The method comprises measuring (S4) a property indicative of a product water flow rate Q.sub.prod, wherein the product water is permeate water that is delivered for consumption, recirculating (S5) a first portion of the reject water, and controlling (S6) a drain flow rate Q.sub.drain to drain, from a second portion of the reject water, to accomplish the target recovery based on the product water flow rate Q.sub.prod.

A system includes a non-transitory computer-readable medium having instructions stored thereon. The instructions, when executed by one or more processors, cause the one or more processors to acquire air quality data regarding an air quality of air upcoming, proximate, or entering an air inlet of a filtration assembly, close or restrict the air inlet in response to the air quality data indicating that the air upcoming, proximate, or entering the air inlet is of a quality lower than a quality threshold to substantially prevent dirty ambient air from entering the filtration assembly, and activate air storage to provide an air supply to the filtration assembly when the air inlet is closed or restricted.

A method for controlling water purification is disclosed. The method comprises measuring a property indicative of an inlet water quality of inlet water to a feed pump and determining a target recovery for the water purification based on the property. The method further comprises controlling a feed pump speed to a predetermined speed, or to a speed determined based on a relation between the feed pump speed, the inlet water quality, and a target permeate water quality, based on the inlet water quality. The method further comprises measuring a property indicative of a product water flow rate, where the product water is permeate water that is delivered for consumption. The method also comprises recirculating a first portion of the reject water and controlling a drain flow rate to drain, from a second portion of the reject water, to accomplish the target recovery based on the product water flow rate.