Provided herein are an apparatus and process for manufacturing a formulation comprising a drug substance, said drug substance comprising a recombinant Listeria strain comprising a prostate specific antigen (PSA) or a chimeric HER2 antigen fused to a Listeriolysin O (LLO) protein fragment.

A reverse osmosis main plant which may receive non-potable water and discharge out permeate through a permeate out line and concentrate through a concentrate line is disclosed.

Methods for producing a bioproduct selected from acetone, isopropanol and a combination thereof with a microorganism in a fermentor are disclosed. The methods include separating cells of the microorganism from a fermentation broth to form separated cells and recycling at least a fraction of the separated cells to the fermentor to achieve one or more of the following: (1) cell concentration in said fermentor greater than 2 g/L; mass yield on a first feedstock greater than 32%; productivity greater than 0.12 g/L/h; and bioproduct titer greater than 10 g/L.

A water filtration system (100) is provided. The water filtration system (100) includes: a filter cartridge assembly (10), a water-intake pipe (20), a purified-water pipeline (30), a pure-water pipeline (40) and a waste discharge pipeline (50). The filter cartridge assembly (10) has a water inlet (110), a purified-water outlet (120), a purified-water return port (130), a pure-water outlet (140) and a waste discharge port (150). The pure-water pipeline (40) is communicated with the pure-water outlet (140), and the pure-water pipeline (40) has a pure-water external port (410) and a second valve (420) configured to control on and off of the pure-water pipeline (40). The waste discharge pipeline (50) has a first end communicated with the waste discharge port (150) and a second end communicated with an outside.

Disclosed herein are systems and methods in which multivalent ions are selectively retained in an aqueous stream. According to certain embodiments, multiple separations may be used to process an aqueous feed stream containing solubilized monovalent ions and solubilized multivalent ions to produce a stream enriched in the solubilized multivalent ions. The separations may be arranged, according to certain embodiments, to enhance the overall separation process such that the product stream containsrelative to the initial aqueous feed streama high amount of solubilized multivalent ions, a high amount of water from the aqueous feed stream, and/or a high ratio of solubilized multivalent ions to solubilized monovalent ions.

The present invention relates to a method of concentrating an aqueous solution by low pressure under a zero osmotic pressure difference condition, and more particularly to a method of concentrating a solute-containing aqueous solution by low pressure under a zero osmotic pressure difference condition. When the method of the present invention is used, there are advantages in that energy consumption is low, and an aqueous solution can be concentrated until it can reach the maximum solute concentration or a solute concentration of 100%, without having to use an extraction solvent. In addition, there is an advantage in that the need to use a separate osmotic pressure draw solution is eliminated.

The present invention relates generally to processes for converting fructose-containing feedstocks to a product comprising 5-(hydroxymethyl)furfural (HMF) and water in the presence of water, solvent and an acid catalyst. In some embodiments, the conversion of fructose to HMF is controlled at a partial conversion endpoint characterized by a yield of HMF from fructose that does not exceed about 80 mol %. In these and other embodiments, the processes provide separation techniques for separating and recovering the product, unconverted fructose, solvent and acid catalyst to enable the effective recovery and reutilization of reaction components.

A forward osmosis process for concentration of lithium-containing salt solutions is described. A difference in osmotic pressure between a lithium-containing salt solution and a second salt solution of higher osmotic pressure is used as a driving force to pass water through a semi-permeable forward osmosis membrane from said lithium-containing salt solution of lower osmotic pressure to the salt solution of higher osmotic pressure. Also, a two-part operation is described wherein reverse osmosis process technology and forward osmosis process technology are used in tandem to concentrate lithium-containing salt solutions and to recover water that can be recycled to the process. The forward osmosis process is conducted without requiring (i) use of superatmospheric pressure or (ii) use of subatmospheric pressure or (iii) use of both such pressures, or (iv) use of one or more additives to assist in causing the flow of water through a forward osmosis membrane.

The present invention relates to a method for producing lithium hydroxide and lithium carbonate, wherein the lithium hydroxide and the lithium carbonate can be produced by a series of steps of: performing bipolar electrodialysis of a lithium-containing solution from which divalent ion impurities have been removed; concentrating lithium in the lithium-containing solution and at the same time, converting the lithium to lithium hydroxide; and carbonating the lithium hydroxide to obtain lithium carbonate.

In one embodiment, a renewable energy storage system includes a forward osmosis system, a hydro-turbine, and a separation (e.g., CEDI) system powered by one or more natural regenerating energy sources, such as wind or solar. In another embodiment, a renewable energy storage system includes a forward osmosis system, a hydro-turbine, a solar thermal heat exchanger through which the diluted osmotic draw solution can be directed for purposes of heating up the draw solution, and a solvent-water separator configured to separate the draw solution from the water. One example method includes drawing water across a forward osmosis membrane in a forward osmosis system such that the water drawn across the membrane dilutes an osmotic draw solution; directing the diluted osmotic draw solution to drive a hydro-turbine to produce energy; and separating the water from the draw solution using one or more natural regenerating energy sources.