The present invention provides, among other aspects, methods for the manufacture of plasma-derived immunoglobulin G compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-A, anti-RAGE, and anti--synuclein antibodies). Advantageously, the methods provided do not affect the manufacturing processes or capabilities for producing plasma-derived IgG therapeutics. Plasma-derived IgG compositions that are highly enriched for anti-brain disease related protein antibodies (e.g., anti-A, anti-RAGE, and anti--synuclein antibodies), as also provided here. Methods for the treatment of brain diseases and disorders by administration of plasma-derived IgG compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-A, anti-RAGE, and anti--synuclein antibodies), are also provided.

Apparatuses and methods of treating, storing, and delivering water such that the water may be suitable for washing, rinsing, etc., without forming water spots on a surface or finish. The disclosed systems and methods may treat and store water by a combination of filtration, reverse osmosis, and/or ion exchange.

Dumping a reverse osmosis (RO) reject stream from a wastewater treatment and reclamation plant (WWTRP) into the sea directly destroys aquatic life and indirectly affects public health. This triggers solving the problem by methods and systems provided herein. One embodiment begins with utilizing two types of waste; one is the RO reject stream in its entirety, and the other is letdown steam from once-through-steam-generators (OTSGs) or steam from a standalone OTSG fueled by co-produced sour gas. It ends with thermally sterilizing toxicity and isolating it by the alkalinity content of the RO reject stream itself, combating sulfate scale and recovering it as a useful product, and producing distillate for heavy oil recovery by steam injection and de-scaled brine for improved oil recovery by water flooding. The vehicle to attain this set of solutions is a recycle-brine multi-stage flash (RB-MSF) desalination train with two modified flashing stages.

A multilayer nano-cell includes an innermost water phase core including biomolecules in an aqueous solution; a first layer, including an oil phase layer encapsulating the innermost water phase core, thereby forming a water-in-oil structure, the oil phase layer including caprylic/capric triglyceride and macrogol-35-glycerol-rizinoleat; a second layer, including a water phase layer encapsulating the first layer, the water phase layer including hyaluronic acid, Cu-GHK tripeptide, palmitoyl-KTTKS pentapeptide, and hexapeptide argireline; a third layer, including another oil phase layer encapsulating the second layer; a fourth layer, including another water phase layer encapsulating the third layer; a fifth layer, including another oil phase layer encapsulating the fourth layer; and a sixth layer, including an outmost cream layer encapsulating the fifth layer.

Produced water from a crude oil or natural gas production process is purified using a membrane purification system for petroleum production, agricultural, commercial and domestic uses. The produced water is pretreated to remove, at least, particulates and oil from the produced water. The minimally pretreated water is then purified in a membrane purification system, that is operated at conditions such that membrane scaling is reduced or prevented. In particular, the membrane purification system is operated to maintain the turbidity of clarified water feed to the system or intermediate aqueous streams that are cascading through the membrane purification system. Ensuring that the turbidity of the reject streams generated in the membrane system are useful in achieving long membrane operating life.

Produced water from a crude oil or natural gas production process is purified using a membrane purification system for petroleum production, agricultural, commercial and domestic uses. The produced water is pretreated to remove, at least, particulates and oil from the produced water. The minimally pretreated water is then purified in a membrane purification system, that is operated at conditions such that membrane scaling is reduced or prevented. In particular, the membrane purification system is operated to maintain the turbidity of clarified water feed to the system or intermediate aqueous streams that are cascading through the membrane purification system. Ensuring that the turbidity of the reject streams generated in the membrane system are useful in achieving long membrane operating life.

A high salinity water purification system and process, including a forward osmosis system and a reverse osmosis or nanofiltration system. A concentrated brine of a zinc or iron complex combined with a salt or acid draws pure water across the FO membrane from the influent water. The diluted brine is pumped through a vessel holding an anionic adsorption media to remove the zinc or iron complex and the resultant brine is passed through the RO or nanofiltration system to obtain purified water and a concentrated brine stream. The adsorption media is regenerated by a rinse cycle using fresh water or water from the RO system, removing the zinc or iron complex adhered to the media. The resultant brine is stored and mixed with the output of the RO system. Charged membrane can be used as a standalone membrane in FO process or in combination with resin or resin embedded membrane.

The analyzing method for quantifying urea in a sample solution includes: a pretreatment step of pretreating the sample solution with at least one of a membrane device including a reverse osmosis membrane and an ion exchange device including an ion exchanger; and an analyzing step of analyzing a target substance in the pretreated sample solution. The analyzing step is based on, for example, flow injection analysis (FIA), and includes a step of quantifying the target substance by measuring the absorbance of a liquid containing a substance generated by reacting the target substance with a reagent.

The present invention relates to a method for separating sialylated oligosaccharides from a fermentation broth in which they are produced by a genetically modified microorganism The separation comprises the steps of: i) ultrafiltration; ii) nano-filtration; iii) optionally, activated charcoal treatment; and iv) treatment with strong anion and/or cation exchange resin.

An object of the present invention is to provide a chemical liquid which has excellent defect inhibition performance and hardly breaks a transfer pipe line that a device for manufacturing the chemical liquid includes at the time of manufacturing the chemical liquid. Another object of the present invention is to provide a chemical liquid storage body, a manufacturing method of a chemical liquid, and a manufacturing method of a chemical liquid storage body. The chemical liquid according to an embodiment of the present invention is a chemical liquid containing an organic solvent and an ion of at least one kind of atom selected from the group consisting of an Fe atom, a Cr atom, a Ni atom, and a Pb atom, in which in a case where the chemical liquid contains one kind of the ion, a content of the metal ion is 0.1 to 100 mass ppt, in a case where the chemical liquid contains two or more kinds of the ions, a content of each of the metal ions is 0.1 to 100 mass ppt, and a charge potential is equal to or lower than 100 mV.