A technology that provides various modular biomimetic microfluidic modules emulating varieties of microvasculature in body. These microfluidic-base capillaries and lymphatic Technology modules are constructed as multilayered-microfluidic microchannels of various shapes, and aspect ratios using diverse biocompatible microfluidic polymers. Then, various semipermeable membranes are sandwiched in between these multilayered microfluidic microchannels. These membranes have different chemical, physical characteristics and MWCO values. Consequently, this design will produce much smaller dimension channels similar to human vasculature to achieve biomimetic properties like of human organs and tissues. By interchanging microfluidic-layers or the membranes various diverse modules are designed that act as building blocks for constructing various medical devices, various forms of dialysis devices including albumin and lipid dialysis, water purification, bioreactors, bio-artificial organ support systems. Connecting various modules in diverse combinations, permutations, in parallel and/or in series to ultimately design many unrelated medical devices such as dialysis, bioreactors and organ support devices.

The present disclosure is directed to methods of purifying solvents. The purified solvents can be used for cleaning a semiconductor substrate in a multistep semiconductor manufacturing process.

An apparatus (100) for purifying fluid, wherein the apparatus (100) comprises an osmosis unit (102) configured for pre-purifying the fluid to be purified by forward osmosis of the fluid, which is to be purified, through an osmosis membrane (104) into a chamber (106) comprising dissolved first ions, in particular first cations and first anions, an ion exchange unit (108) configured for exchanging at least part of the first ions, in particular at least part of at least one of the first cations and the first anions, by second ions, in particular at least one of second cations and second anions, and a re-concentration unit (110) configured for separating the pre-purified fluid after the ion exchange into purified fluid and into a re-concentrate enriched with the respective ions, in particular anions and cations.

An apparatus (100) for purifying fluid, wherein the apparatus (100) comprises an osmosis unit (102) configured for pre-purifying the fluid to be purified by forward osmosis of the fluid, which is to be purified, through an osmosis membrane (104) into a chamber (106) comprising dissolved first ions, in particular first cations and first anions, an ion exchange unit (108) configured for exchanging at least part of the first ions, in particular at least part of at least one of the first cations and the first anions, by second ions, in particular at least one of second cations and second anions, and a re-concentration unit (110) configured for separating the pre-purified fluid after the ion exchange into purified fluid and into a re-concentrate enriched with the respective ions, in particular anions and cations.

The present invention provides, among other aspects, methods for the manufacture of plasma-derived immunoglobulin G compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-A, anti-RAGE, and anti--synuclein antibodies). Advantageously, the methods provided do not affect the manufacturing processes or capabilities for producing plasma-derived IgG therapeutics. Plasma-derived IgG compositions that are highly enriched for anti-brain disease related protein antibodies (e.g., anti-A, anti-RAGE, and anti--synuclein antibodies), as also provided here. Methods for the treatment of brain diseases and disorders by administration of plasma-derived IgG compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-A, anti-RAGE, and anti--synuclein antibodies), are also provided.

Systems and methods of making lactobionic acid are described. The systems include two-compartment cation bipolar electrodialysis assemblies having at least one cell that includes a cation ion-exchange membrane and a bipolar membrane. The membranes define the borders of a pair of flow channels for a separate (i) caustic stream and (i) purified lactobionic acid stream. Lactobionate ions in the lactobionic acid stream do not cross a membrane in the electrodialysis assembly, which reduces membrane fouling. The methods include passing a lactobionate salt through a two-compartment cation bipolar electrodialysis assembly. The electrodialysis assembly includes at least one two-compartment cation bipolar membrane cell, and separates the lactobionate salt into a caustic compound and the lactobionic acid. The assembly is designed so the lactobionate ions do not cross an ion exchange membrane in the assembly to form the lactobionic acid, which reduces membrane fouling.

A purification device for water has a housing with a longitudinal axis, an upper and a lower end and a substantially round cross section. The device includes a first receptacle, arranged parallel to the longitudinal axis of the housing, for a first purification medium, and a second receptacle, which is also arranged parallel to the longitudinal axis of the housing, for a second purification medium. The receptacle for the second purification medium is arranged eccentrically with respect to the longitudinal axis of the housing.

The present invention relates to the extraction of lithium from liquid resources, such as natural and synthetic brines, leachate solutions from clays and minerals, and recycled products.

A portable water conditioning system is provided that includes a water conditioner, a first sensor, a second sensor, and a controller. The water conditioner has a plurality of conditioning stages that condition water. The plurality of conditioning stages include, in a direction of flow of the water through the water conditioner, a reverse osmosis stage and a deionizing stage. The first sensor detects a first condition of the water before the reverse osmosis stage. The second sensor detects a second condition of the water after the reverse osmosis stage. The controller is in communication with the first and second sensors and determines a health status of the reverse osmosis stage based the first and second conditions. The first and second conditions each include a level of total dissolved solids of the water.

The present invention relates to a method for purifying water using at least one unit for trapping one or more ions and at least one membrane filtration unit, wherein an aqueous stream is withdrawn from a source and is fed to the aforementioned unit for trapping one or more ions, wherein the aqueous stream leaving the aforementioned unit is fed to the aforementioned membrane filtration unit, and at least one concentrate stream and one permeate stream are obtained in said membrane filtration unit, wherein at least part of the aforementioned one or more ions that are trapped is added to the aforementioned permeate stream to obtain a permeate stream enriched with one or more ions.