A flat membrane support plate includes a connection portion, a honeycomb structural portion and a support portion. The connection portion is configured to connect a diaphragm to the flat membrane support plate in a sealing manner, is arranged at a periphery of the flat membrane support plate, and is provided with at least one water outlet. The honeycomb structural portion is arranged on the flat membrane support plate in an area enclosed by the connection portion, is provided with a first flow channel for communicating with an interior of the entire honeycomb structural portion and communicating the honeycomb structural portion with the water outlet. The support portion is configured for reinforcing the honeycomb structural portion and is arranged between the honeycomb structural portion and the connection portion.

Disclosed is a method for preparing a precursor of a recombinant human insulin or an analogue thereof, comprising: a. bacterial fermentation, centrifuging a fermentation broth in a continuous flow to collect a supernatant; b. filtering the supernatant in step (a) by means of a hollow fiber membrane and collecting the filtrate; and c. purifying the filtrate in the step (b) by means of a chromatography column. The method has the advantages of streamlined steps, scalability, no use of organic solvents, high yield, etc. The purity of the insulin precursor can exceed 90%, the host cell protein removal rate exceeds 90%, and the exogenous DNA removal rate is 89% or greater, achieving less than 0.1 ng/mg.

The present invention relates to separation of desired target products from biological, plant, and waste-type material, wherein the desired target products include renewable fuels such as ethanol, biobutanol, and biodiesel, wherein the separation is conducted with a cross-flow filtration system having the ability to separate desired products from both non-viscous and viscous medium.

The present invention relates to a method for removing biopolymer aggregates and viruses from a fluid. In a first step, the biopolymer aggregates are selectively removed by filtration through a porous, polyamide-comprising shaped body having a native surface. In a second step, the biopolymer aggregate-free fluid is filtered through at least one suitable virus-retentive membrane.

The present invention relates to a method for removing biopolymer aggregates and viruses from a fluid. In a first step, the biopolymer aggregates are selectively removed by filtration through a porous, polyamide-comprising shaped body having a native surface. In a second step, the biopolymer aggregate-free fluid is filtered through at least one suitable virus-retentive membrane.

The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.

A manufacturing facility for the continuous production of biopharmaceuticals integrated with single-use disposable technology.

A process for treating waste water, including the steps of extracting by forward osmosis treated water from a wastewater feed stream and transferring it to a saline draw stream, and extracting from the saline draw stream treated water by a reverse osmosis process.

We provide methods, systems, and apparatus for treatment of high chemical oxygen demand wastewater using anaerobic treatment with ceramic membranes. We also provide post-treatment using microbial fuel cells.

Disclosed are methods of treating wastewater using a membrane bioreactor and achieving a target phosphorus concentration for the membrane permeate stream. These methods include the steps of dosing a wastewater stream with a rare earth clarifying agent and passing the dosed wastewater stream through the membrane to obtain a membrane permeate stream with a permeate concentration that is less than the phosphorus concentration of the influent stream. This permeate concentration also can be equal to or less than a target phosphorus concentration. In the methods as disclosed herein, the rare earth clarifying agent can be chloride salts of one or more rare earth elements and in certain embodiments, the rare earth clarifying agent can be CeCl.sub.3 and LaCl.sub.3.