Provided is a membrane module which has a simple and easy structure to restrain its vessel from being increased in costs, and which allows to fabricate the vessel by a simple and easy work, and further to locate an inlet for a fluid, and others at respective predetermined positions of the membrane module.

A fluid to fluid pressurizer includes an elongated stationary portion comprising a plurality of flow channels, said stationary portion comprising a first face at a first end and a second face at a second end. A first and second rotor housing are disposed adjacent to the end of the elongated stationary portion and have a fluid inlet fluidically coupled to respective first and second annular channels. A first and second rotary valve plates are in the housings and have inlet valve ports coupling the fluid inlet to the plurality of flow channels and outlet valve ports fluidically coupling the flow channels to adjacent the rotor faces. The rotary valve plates have sealing surfaces adjacent the stator faces. Annular seals are disposed between the rotor housings and the rotary valve plate between the annular channels. A motor or motors rotate the rotary valve plates within the housings.

A fluid to fluid pressurizer includes an elongated stationary portion comprising a plurality of flow channels, said stationary portion comprising a first face at a first end and a second face at a second end. A first and second rotor housing are disposed adjacent to the end of the elongated stationary portion and have a fluid inlet fluidically coupled to respective first and second annular channels. A first and second rotary valve plates are in the housings and have inlet valve ports coupling the fluid inlet to the plurality of flow channels and outlet valve ports fluidically coupling the flow channels to adjacent the rotor faces. The rotary valve plates have sealing surfaces adjacent the stator faces. Annular seals are disposed between the rotor housings and the rotary valve plate between the annular channels. A motor or motors rotate the rotary valve plates within the housings.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

A filtration vessel, having within constituent filter media is formed using plastic injection molding to meet the interior specifications of a high-pressure filtration encasement system while remaining a separate replaceable component. The encasement system supports and encases walls of the filtration vessel enabling the vessel to be designed with sufficient strength and resiliency to form a seal and constrain filter media prior to and after use without necessitating construction to endure independent high-pressure operations. The bottom or base of the vessel includes a plurality of holes through which the filtrate may flow. Interposed between the base of the vessel and the filter media is a semi-permeable barrier imbedded into the injection molded walls and base of the vessel. The barrier prevents residue from contaminating the filtrate.

A resin barrier device for connection in a vacuum line, for use in resin infusion during composite manufacture, includes a housing having an inlet port for connection to a resin source and an outlet port for connection to a vacuum source. A flow path extends between the inlet and outlet ports. A gas-permeable membrane is disposed across the flow path to prevent resin from flowing to the vacuum pump. A gasket supports the membrane and is adapted to prevent resin leakage. A method of infusing a preform with a resin also is provided.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

The present disclosure relates to a gasket assembly that can be manufactured with improved productivity and can dramatically reduce maintenance costs, and a fuel cell humidifier including the same. A gasket assembly according to an embodiment of the present disclosure is provided for a fuel cell humidifier including a mid-case, a cap fastened to the mid-case, and at least one cartridge disposed in the mid-case and accommodating a plurality of hollow fiber membranes.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

Filtration apparatus for the assay of biological and biochemical reactants, for example, is provided and includes a substrate such as a plate having one or more wells open at each end, and a porous membrane positioned in each well forming a discrete filtering area. The filtration apparatus includes a seal that is in a compressible relationship with the face of the porous membrane, the surface of the compression element, and the well wall. Each well includes a compression element, such as an internal well insert or sleeve, which compresses the seal so that the seal contacts the membrane face, the surface of the compression element, and the well wall in a liquid-tight manner. The compression element may be configured so that it is fixed in the well such as by an interference fit with the well wall or by bonding to a surface of the substrate.