The present invention provides a membrane filtration module comprising a housing in which the filtration membrane is disposed in a fixed positional relationship by a potting or bonding material obtained by the curing of a two component (2K) composition consisting of: a first component (A) comprising at least one compound (a) having at least two acetoacetate functional groups; and, a second component (B) comprising at least one compound (b) having at least one amino group, each said amino group being a primary or secondary amino group.

A reverse osmosis filtering module includes: a purified water discharge pipe in which a purified water discharge path is formed, and which has a communication hole that is formed on an outer periphery thereof and communicates with the purified water discharge path; a reverse osmosis filtering part including a reverse osmosis filtering member in which a purified water flow space is formed, and which is wound around the purified water discharge pipe such that the purified water flow space communicates with the communication hole; a first flow channel formation cap provided at one side and having an inlet hole; and a second flow channel formation cap provided at the other side of the reverse osmosis filtering part and having an outlet hole.

A sanitary membrane cartridge for use in reverse osmosis filtering includes an outer housing, a central core tube, and a membrane leaf wound around the central core tube to form a cylindrical filter. The cartridge further includes a sealant layer disposed around the cylindrical filter to form a sealed filter, the sealed filter disposed within the housing. The sealant layer preferably has a surface roughness value, Ra, ranging from about 0.38 m to about 0.82 m. The cartridge further includes a brine seal, disposed between the sealant layer and the housing, having one or more notches formed on an outer diameter of the brine seal such that the feed flow through the notches allows bypass flow, between the sealant layer and the housing, of 1% to 25% of a total feed flow through the sealed filter.

A filtration unit for purifying or treating fluid that includes one or more membrane units having a permeate section. The permeate section of the membrane units is fed fluid that passes through a sealing insert having a fluid inlet and a passage that discharges in fluid communication with the permeate section. The sealing insert is arranged in a support frame of the membrane unit to form a fluid channel for delivering fluid through the insert and along an outer perimeter surface that maintains performance of the membrane unit during operation.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

A spiral wound membrane module adapted for hyperfiltration and including at least one membrane envelope and feed spacer sheet wound about a central permeate tube to form an inlet and outlet scroll face and an outer periphery, wherein the feed spacer sheet includes: i) a feed entrance section extending along the permeate collection tube from the inlet scroll face toward the outlet scroll face, ii) a feed exit section extending along the outer periphery from the outlet scroll face toward the inlet scroll face, and iii) a central feed section located between the feed entrance section and the feed exit section; and wherein the feed entrance section has a median resistance to flow in a direction parallel to the permeate collection tube that is less than 25% of the median resistance to flow of the central feed section in a direction perpendicular to the permeate collection tube.

An apparatus is disclosed for separating and preserving biomolecules of a biological fluid sample. The apparatus includes an assembly having sides forming a hollow shape having a first opening at one end and second opening at the opposite end, a sample mixing chamber positioned adjacent the first opening within the assembly, the sample mixing chamber from which a flow of the biological fluid sample is actuated in a direction from the sample mixing chamber to the first matrix layer, the sample mixing chamber being in a direction downstream of the first opening, a first valve positioned between the sample mixing chamber and the first matrix layer, the first valve configured to control the flow to the first matrix layer, a first input in fluid communication with the sample mixing chamber and positioned upstream of the first valve, a second input positioned between the first matrix layer and the second matrix layer, and a second valve positioned between the second matrix layer and the second opening, the second valve configured to control the flow to the second matrix layer.

A filter element assembly comprises a filtration media and an end fitting through which a sealing connection is made between the assembly and a housing so that the end fitting defines a flow path between the housing and the filtration media. The end fitting has first and second parts which can be separated axially, and the filter media extends axially away from the second part in a direction away from the first part. Each of the parts has an outer wall with an external threaded cylindrical surface, and each of the first and second parts has an axially facing edge surface which faces the other of the first and second parts, the facing edge surfaces shaped to define a pre-determined relative rotational alignment of the first and second parts, where the parts fit together so that the threads on the external surfaces of the parts form a continuous thread.

Cassettes for tangential flow filtration (TFF) are disclosed which reduce assembly and disassembly required for aseptic filtration. Packaging systems and methods for the TFF cassettes are also disclosed.