The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

The invention relates to membrane modules, in particular membrane pocket modules, which comprise membrane pocket stacks which are disposed in a housing having at least one feed inlet, at least one retentate outlet, and at least one permeate outlet. The invention also relates to the use of the membrane module according to the invention for separating mixtures of liquids and/or gases. The membrane of the previously known type, also referred to as a GS module, comprises a housing which for forming a container interior space by means of finisher discs at two end sides is closed in a pressure-tight manner. The finisher discs comprise at least one feed inlet, at least one retentate outlet, and one permeate outlet, wherein at least one membrane pocket stack which has a plurality of membrane pockets which are lined up beside one another and are mutually separated by seals and which are push-fitted onto a permeate tube is disposed in the container interior space. The permeate tube protrudes beyond the at least one permeate outlet of the finisher discs. The membrane module according to the invention is characterized in that the permeate tube and the permeate outlet of the finisher discs are aligned in an alternating manner by way of a key-and-groove connection.

A central tube assembly for a filter cartridge and a manufacturing method for the central tube assembly are provided. The central tube assembly includes a first half-tube defines a first flow passage, and having a first water inlet at an end thereof and a water output hole in a side wall thereof a filtering membrane bent to form a first membrane layer and a second membrane layer, the first half-tube being disposed between the first membrane layer and the second membrane layer; an input-water filtering net connected to the first half-tube and disposed between the first membrane layer and the second membrane layer a second half-tube disposed outside of a bending of the filtering membrane, defining a second flow passage, and having a water input hole in a side wall thereof and a first water outlet at an end thereof and a produced-water filtering net.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

A selectively permeable membrane device for separating a first fluid from a second fluid in a flow can include a membrane conduit configured to receive the flow and to allow permeation of the first fluid therethrough, and configured to not allow permeation of the second fluid. The device can include a residence time enhancing structure disposed within the membrane conduit and configured to increase residence time of the flow within the membrane conduit.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

There is provided a single pass electro-separation system for separating substantially all of a charged molecule from a fluid stream in a single pass, the system comprising an assembly adapted to be disposed between a cathode and an anode. The assembly comprises: at least a first, second, and third separation membrane each having defined pore sizes; a first spacer disposed between the first and second separation membranes and having a void extending from an inlet to an outlet to define a first fluid flow path for a first fluid stream between the first and second separation membranes; and a second spacer disposed between the second and third separation membranes and having a void extending from an inlet and an outlet to define a second fluid flow path for a second fluid stream between the second and third separation membranes

Hydrogen generation assemblies, hydrogen purification devices, and their components, and methods of manufacturing those assemblies, devices, and components are disclosed. In some embodiments, the devices may include an insulation base having insulating material and at least one passage that extends through the insulating material. In some embodiments, the at least one passage may be in fluid communication with a combustion region.

A fuel tank inerting system uses a catalytic oxidation unit to combust fuel from the fuel tank to produce inert gas, simultaneously working with a gas separator that removes dissolved carbon dioxide from the fuel before it is cycled to the thermal management system (TMS) or the engine. This prevents cavitation of carbon dioxide (gaseous bubbling) within the fuel at varying temperatures while in flight.

A fuel tank inerting system uses a catalytic oxidation unit to combust fuel from the fuel tank to produce inert gas, simultaneously working with a gas separator that removes dissolved carbon dioxide from the fuel before it is cycled to the thermal management system (TMS) or the engine. This prevents cavitation of carbon dioxide (gaseous bubbling) within the fuel at varying temperatures while in flight.