Membrane cell stack arrangement comprising a housing, a stack of membranes defining flow compartments and a fluid manifold system, wherein the direction of flow through the flow compartments is different to the direction of flow through entry and exit openings and the width of the entry and exit openings are each larger than 45% of the width of the flow compartment.

The reverse osmosis centrifuge converts rotational energy into fluid velocity and conserves the energy placed into the concentrate. As concentrate travels back towards the center of the reverse osmosis centrifuge, the velocity of the fluid is converted into rotational force, thus conserving energy placed into the concentrate. To accomplish this, the reverse osmosis centrifuge includes a support shaft, a plurality of receiving tubes, a plurality of housings with filters therein, a plurality of departure tubes, and a permeate trough. The plurality of receiving tubes are coupled to a top of the plurality of housings, while the plurality of departure tubes are coupled to a bottom of the plurality of housings. Centrifugal force creates the permeate and concentrate. The permeate exits the plurality of housings and is deposited into the permeate trough. The concentrate travels through, and exists from, the plurality of departure tubes.

The specification discloses a portable dialysis machine having a detachable controller unit and base unit. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The manifold includes diaphragms adapted to minimize the dead space between the dialysis machine pins and improve responsivity. The base unit has a planar surface for receiving a container of fluid, a scale integrated with the planar surface and a heater in thermal communication with the container. Embodiments of the disclosed portable dialysis system have improved structural and functional features, including improved modularity, ease of use, and safety features.

A device for separating a gas, such as air, into components, includes a plurality of modules, each module having one or more polymeric membranes capable of gas separation. A set of valves, pipes, and manifolds together arrange the modules in one of two possible configurations. In a first configuration, the modules are arranged in parallel. In a second configuration, the modules are divided into two groups which are arranged in series. The device can be switched from parallel to series, or from series to parallel, simply by changing the positions of a small number of valves, typically three valves. The device can therefore produce gas either of higher purity, or moderate purity, depending on the settings of the valves.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

A module comprises a cell stack having a plurality of alternating ion depleting compartments and ion concentrating compartments, an inlet manifold configured to facilitate a flow of fluid into the cell stack, and a first flow distribution system, associated with the inlet manifold, including a first ramp to promote the circulation of the flow of fluid into the cell stack.

The invention concerns a device comprising a base (2) and a door (20), said device having a closed door position in which a circuit (8) of the device comprises a bag comprising two flexible films and connectors of the conveying network, and a press (9) comprising a first shell (16) disposed on a front face (5) of said base (2) and a second shell (17) disposed in said door (20); and a hinge system hinging said door (20) relative to said base (2), and disposed only on one side of said door (20) so as to form lateral clearances between said door (20) and said base (2) over the rest of a perimeter of said door (20).

There is disclosed a fluid distribution system for distributing fluid from a single source to a plurality of downstream receptacles. The system has a distribution manifold with a single inlet and a plurality of outlets arrayed around a circumferential outer periphery. The outlets may be directed to the different receptacles which each have their own vent filter, or each receptacle connects back to the distribution manifold for common venting.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.