The specification discloses a portable dialysis machine having a detachable controller unit and base unit. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a planar surface for receiving a container of fluid, a scale integrated with the planar surface, a heater in thermal communication with the planar surface, and a sodium sensor in electromagnetic communication with the planar surface. Embodiments of the disclosed portable dialysis system have improved structural and functional features, including improved modularity, ease of use, and safety features.

A membrane contactor for degassing a gas-entrained liquid and to discharge gas-depleted liquid includes: a shell has two ends; a cap closes one shell end; a membrane extends between the shell ends and is enclosed within the shell; a first center tube discharges the gas-entrained liquid into the membrane; a second center tube discharges the gas-depleted liquid from the contactor; and one tube surrounds the other tube. The membrane may be a flat sheet membrane or a hollow fiber membrane. The cap has an in let in fluid communication with the first center tube and an outlet in fluid communication with the second center tube. A baffle may be located within the membrane between the shell ends.

Fluid treatment system comprising a row of vertically arranged cylindrical filtration modules having a cylindrical shell, an upper end, a lower end and a shell interior and an upper and a lower header coupled to upper and lower end of the shell. In the shell interior, hollow fiber membranes are embedded with their ends in an upper and a lower tube sheet and are open at the ends. An exterior filtrate space is formed around the membranes extending between upper and lower tube sheets and an inner surface of the shell. Upper and lower head spaces are formed between upper and lower tube sheets and the respective headers. The lumina of the hollow fiber membranes are in fluid communication with the head spaces. The cylindrical shells comprise outlet ports being in fluid communication with the exterior filtrate spaces and being connected to a filtrate branch pipe. Upper headers are in fluid connection with each other thereby forming an upper collecting duct running along the row at the same level as or above the upper headers. Lower headers are in fluid connection with each other thereby forming a lower collecting duct running along the row on the level of or below the lower headers. The filtrate branch pipes are connected to and open into a filtrate collecting pipe running lengthwise of the row at the upper end of the filtration modules. Upper collecting duct and filtrate collecting pipe are arranged at the upper headers eccentrically and on different sides with respect to a cross-sectional center of the shell and parallel to each other at the same height level.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.

An apparatus is disclosed for separating and preserving biomolecules of a biological fluid sample. The apparatus includes an assembly having sides forming a hollow shape having a first opening at one end and second opening at the opposite end, a sample mixing chamber positioned adjacent the first opening within the assembly, the sample mixing chamber from which a flow of the biological fluid sample is actuated in a direction from the sample mixing chamber to the first matrix layer, the sample mixing chamber being in a direction downstream of the first opening, a first valve positioned between the sample mixing chamber and the first matrix layer, the first valve configured to control the flow to the first matrix layer, a first input in fluid communication with the sample mixing chamber and positioned upstream of the first valve, a second input positioned between the first matrix layer and the second matrix layer, and a second valve positioned between the second matrix layer and the second opening, the second valve configured to control the flow to the second matrix layer.

A single-use filtration device (10) comprises a plurality of single-use filter capsules (12) connected with each other by rigid lines, of which at least a part is firmly mounted in a raster universally specified by a holder (14). The filter capsules (12), in particular as regards the type of filter, type of construction and/or size, and/or the connections of the filter capsules (12), are preconfigured for a desired filtration process.

The invention relates to a connection device for receiving and connecting filter modules, in particular tubular filter modules, having at least one lateral, in particular radial, connector wherein a connecting apparatus of the connection device connects the filter module at the lateral connector and fixes it in the connection device. Further connecting apparatus of the connection device serve in the connecting of connectors arranged coaxially on the filter module, wherein the coaxial connectors are not fixed via the further connecting apparatus.

The specification discloses a portable dialysis machine having a detachable controller unit and base unit with an improved reservoir heating system. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a reservoir with an internal pan and external pan, separated by a space that holds a heating element. The heating element is electrically coupled to electrical contacts attached to the external surface of the external pan.

The invention relates to a method for producing a device for a mass transfer between two fluids, wherein at least one hollow-fiber mat (9) is wound on an at least partly hollow core assembly (1, 1a, 1b, 2), and the formed coil is inserted into a housing (10). The assembly of the housing (10) and the coil is then sealed (10), in particular potted, with a sealant at the opposing axial ends in the regions between the hollow-fiber ends and the housing. The core assembly (1, 2) is made of at least two axially adjacent core parts (1, 1a, 1b, 2) arranged one behind the other, at least one (1, 1a, 1b) of which has a hollow design, and the core parts (1, 1a, 1b, 2) are kept in specified axial positions relative to each other, in particular at a distance to each other, by means of at least one aid element (7) at least over the period of the sealing process and preferably over the period of the winding process as well. After the sealing process and the removal of the at least one aid element (7), at least the axially end-face core parts (1, 1a, 2) are kept in their relative positions to each other by means of the sealant. The invention also relates to a coil, a core assembly, and a core system.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methodsincluding high throughput methodsfor screening cells that have been subjected to editing and identifying cells that have been properly edited.