A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.

Embodiments of the present invention provide for the deposition of spacing elements for spiral wound elements which promote mixing within the feed space during element operation thereby improving element performance and reducing concentration polarization and potential for biological fouling.

Cassettes for tangential flow filtration (TFF) are disclosed which reduce assembly and disassembly required for aseptic filtration. Packaging systems and methods for the TFF cassettes are also disclosed.

A raw water channel spacer capable of suppressing formation of a concentration polarization layer in a region in the vicinity of a separation membrane in a raw water channel, and a spiral wound membrane element including the same are provided. A raw water channel spacer is formed by superposing a first yarn row and a second yarn row, and includes alternately a first mesh structure having a configuration in which first rectangular meshes formed of the yarn rows are continuous in an extending direction of the second yarn row, and a second mesh structure having a configuration in which meshes are continuous in the extending direction of the second yam row such that an interval in the second yarn row is smaller than an interval of the second yarn row forming the first mesh structure.

A permeate carrier for reverse osmosis, nanofiltration, ultrafiltration, or microfiltration systems is provided. The permeate carrier includes a tricot knitted fabric sheet which includes synthetic yarns knitted into pillars formed by a 1-0, 0-1 lapping pattern or a 0-1, 1-0 lapping pattern and cross ribs formed by a 2-3, 1-0 lapping or a 1-0, 2-3 lapping pattern. The permeate carrier is configured for placement between adjacent filter membranes in a water filtration system.

A process for separating a feed gas comprising a polar gas and a non-polar gas into a permeate gas and a retentate gas, one of which is enriched in the polar gas and the other of which is depleted in the polar gas, the process comprising passing the feed gas through a gas separation module comprising: (i) a feed carrier comprising a membrane envelope and a feed spacer located within the membrane envelope; and (ii) a permeate carrier comprising: (a) a macroporous sheet; and (b) a protective sheet; and wherein: i) the feed gas is fed along the feed spacer of the feed carrier and a part of the feed gas passes through the membrane envelope and into the permeate carrier to give the permeate gas and a part of the feed gas is rejected by the membrane to give the retentate gas; ii) the protective sheet shields at least a part of the membrane envelope from contact with the macroporous sheet; and iii) the protective sheet comprises a non-woven material.

A spiral-wound type gas separation membrane element includes a central tube and a laminate wound around the central tube. Laminate includes at least one structure where a feed-side flow path member, a gas separation membrane, and a permeate-side flow path member are superimposed in this order. Permeate-side flow path member has a thickness of 400 m to 1300 m. Gas separation membrane is a membrane where a hydrophilic resin composition layer, a porous layer, and a permeate-side surface layer are superimposed in this order. Permeate-side surface layer faces Permeate-side flow path member and has a Young's modulus of 20 MPa to 400 MPa.

The present invention addresses the problem of providing a separation membrane element with which it is possible to stabilize the separation removal performance when a separation membrane element is operated. The present invention is a separation membrane element provided at least with a collecting pipe, a separation membrane, a feed-side channel material, and a permeation-side channel material, wherein: the feed-side channel material is configured from a fibrous column X configured from a plurality of fibrous materials A arranged in one direction and a fibrous column Y configured from a plurality of fibrous materials B arranged in a different direction to the fibrous column X; the fibrous materials A intersect the fibrous materials B to form intersections; and the fibrous materials A and/or the fibrous materials B have a small-diameter part and a large-diameter part between adjacent intersections in a section plane parallel to the respective fibrous column.

Membrane elements that use multiple membrane leaves may have a limited total active membrane area due to an increased diameter at the ends of the element. Membrane leaves may comprise a permeate carrier positioned between one or more membrane sheets. Adhesive may be used to seal one or more edges of the membrane leaf. The membrane sheets, permeate carrier and the adhesive contribute to the thickness of the edges of the membrane leaf and the diameter at the ends of the element. A reduced thickness of the edges of the permeate carrier may reduce the diameter at the ends of an element. Another permeate carrier sheet may also be used that is distanced from at least one edge of the membrane sheet so the permeate carrier sheet does not contribute towards the increased diameter at the ends of the element.

A piece of substrate material is formed under heat and pressure against a cavity into a shaped substrate sheet having one or more depressions. Two substrate sheets are bonded together to form a substrate wherein the one or more depressions form one or more interior channels. The substrate, if not formed with pre-coated substrate material, is coated with a dope and quenched to form a filtering membrane. A plurality of membranes may be placed side by side to form a bundle with permeating ends of the membrane, which are open to the one or more interior channels, separated by gaps or spacers. The bundle is connected to a header to produce a module. The module can be assembled into a cassette.