The subject of the invention is a membrane for separation of target stem cells from biological samples, more precisely from a single-cell suspension that was prepared from a biological sample. As a result, sterile target stem cells are obtained in physiological buffer. The membrane of the invention consists of a 3D carrier structure made of at least one layer of biocompatible polymer with specific pore size, as a carrier material, and covalently bound target molecules on its surface and/or in the pores. These target molecules are preferably target antibodies, which recognize characteristic antigens that are bound on the surface of the target stem cells and thus bind the target stem cells to the membrane. Target molecules can be either directly bound to the surface and/or in the pores of the carrier structure or are bound to the surface and/or in the pores of the carrier structure through specific functionalized nanoparticles, which are bound to or embedded into the 3D carrier structure of the membrane. In addition, the present invention includes the membrane production process as well as the process and device for the separation of target stem cells from a biological sample, which includes the above membrane as a constituent part.

The disclosure provides a filtration system for a cell culture apparatus and a method of cell culture. The filtration system comprises a bioreactor vessel and two or more alternating tangential flow (ATF) filters connected in parallel. A failure in either filter is detected by an in-line sensor, and an automated response system functions to sequester the malfunctioning filter by stopping the flow of liquid media through the filter. Media flow through the remaining operable filters can be increased so that the rate of perfusion through the bioreactor remains relatively unchanged. Such a system may prevent issues that arise from ATF filter failures in conventional perfusion bioreactors, thereby improving the long-term viability of cell cultures.

The present disclosure is directed to filtering technologies that combine elements of continuous and batch NF/RO based on the constraints of the end-user facility to achieve a target balance between, for instance, recovery and power consumption, and to reduce long term operating cost of a plant. A method for extending batch operation into a second induction period with antiscalant injection is also disclosed herein, with the second induction period allowing for yet higher water recovery.

The present invention provides a hollow fiber membrane module which makes it possible to concentrate incubated platelets by efficiently removing water from an incubated platelet suspension liquid containing incubated platelets while suppressing deterioration of the function of the incubated platelets. The present invention provides an incubated platelet concentration module in which a plurality of hollow fiber membranes each having pores with an average pore diameter of 2 μm or less on a surface of the hollow fiber membrane are packed in a casing having at least one inlet for supplying an incubated platelet suspension liquid before concentration into the hollow fiber membranes, wherein a value (X/Y1) obtained by dividing a total cross-sectional area (X) of the plurality of hollow fiber membranes by a total cross-sectional area (Y1) of the least one inlet is 4.0 or less.

A high recovery variable volume reverse osmosis system where the volume of concentrate cycled through the RO system is reduced in response to recovery levels increasing. By reducing the volume of concentrate cycled through the RO system, this reduces the cycle time of highly saturated concentrate passing through the RO system. Reducing the cycle time of concentrate passing through the RO system tends to minimize or reduce membrane scaling.

A water purifier includes a water purifier body, a filter bracket provided inside the water purifier body, a pump unit provided inside the water purifier body and including a pump connected to a main water purifying filter installed in the filter bracket, and a vibration transmission-preventing unit which, while the main water purifying filter is installed in the filter bracket, ensures the transmission, to the filter bracket and the water purifier body, of vibrations due to the pressure difference between the pump and the main water purifying filter when water is supplied to the main water purifying filter by means of the pump is reduced by a filter vibration-damping member.

Implementations of a water filtration system are provided. In some implementations, the water filtration system comprises a housing having a plurality of ports for receiving and outputting fluids wherein the housing encloses components configured to, in a filtration mode, filter water received through one of the plurality of ports to produce potable water and output the potable water through one of the plurality of ports and wherein the housing encloses components configured to, in a flush mode, use fluid received through one of the plurality of ports to remove contaminants captured in the water filtration system and output the contaminants through one of the plurality of ports.

The present invention relates to a method for dynamic filtration of a cross-linked biopolymer-based hydrogel to remove unwanted molecules from the gel. In particular, the invention relates to dynamic filtration of a hyaluronic acid hydrogel using a dynamic filtration construction with rotating and semipermeable filter discs.

The disclosure generally relates to methods and apparatus for the efficient quantitative recovery of valuable biological fluids from filtration systems, more particularly to efficient quantitative recovery of valuable biological fluids from high precision separation systems suitable for use in the pharmaceutical and biotechnology industries.

A desalination system including: a partitioned container having upstream and downstream compartments divided by a movable partition, a first inlet port at an upstream end, and a second inlet port and an outlet port at the downstream end; a membrane container housing a cross-flow semipermeable membrane dividing the membrane container into saline and desalinated compartments, the saline compartment including first and second cross-flow ports, the desalinated compartment including a desalinated water outlet port; a feed pump connected to the first inlet port; a recharge pump having an inlet connected to the second cross-flow port and an outlet connected to the second inlet port; a main valve connected between the outlet port and the first cross-flow port; a bypass valve connecting the inlet port to the second cross-flow port and the recharge pump inlet; and a purge valve connecting the first cross-flow port and the main valve to a purge port.