A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.

The present invention provides for a method for separating starch from processing solutions containing starch containing plants or roots such as potatoes, sweet potatoes, wheat, corn, tapioca, yams, cassaya, sago, rice, pea, broad bean, horse bean, sorghum, konjac, rye, buckwheat and barley to provide commercially acceptable starch while reducing disposal of solid or liquid waste matter into landfills or water treatment facilities.

This disclosure provides a method for concentrating a solution of a macromolecule that is retained on at least two semi-permeable membranes that have different molecular weight cutoffs (MWCOs), the method comprising passing the solution through a hybrid configuration of said semi-permeable membranes staged in series in a single pass tangential flow filtration (SPTFF) apparatus. The method is applicable to the efficient concentration of biological macromolecules such as proteins, antibodies and nucleic acids.

A turbocharger includes a turbocharger housing having an impeller housing comprising a circular cross-section. A main nozzle is disposed within the turbocharger housing communicating a first portion of a fluid stream to a first volute. A first auxiliary channel and a first auxiliary nozzle communicating a second portion of the fluid stream to the first volute. The first auxiliary nozzle is downstream of the main nozzle. A second auxiliary channel and a second auxiliary nozzle communicate a third portion of the fluid stream to the first volute. The second auxiliary nozzle is downstream of the first auxiliary nozzle. A valve assembly is selectively coupling the first auxiliary channel to the first auxiliary nozzle and the second auxiliary channel to the second auxiliary nozzle.

The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.

A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

A two-stage gas-separation membrane system includes two identical membrane modules held within a single casing. A feed gas is directed into the first module, so as to produce permeate and retentate streams. One of the latter streams then becomes the feed gas for the second module, and reaches the second module through a core tube located within the module. The product of the second module is the product gas for the system. The gas streams entering the two modules flow in mutually opposite directions. This arrangement makes it feasible to provide a two-stage system while using only the number of ports that would be needed for a single stage.

A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.

A purification system for a colloidal dispersion containing an unwanted dissolved substance in the dispersing liquid phase is described which includes a back-pressure regulating feature, disposed in a first conduit and downstream of a semi-permeable filter element. This is used to force a portion of the unpurified dispersing liquid across the filter element and into a second conduit. The second conduit is associated with an adsorptive element that serves to remove the unwanted dissolved substance from the filtered portion of the dispersing liquid. A mixing chamber is disposed downstream of the back-pressure regulating feature whereby the purified dispersing liquid portion from the second conduit rejoins the bulk flow of the colloidal dispersion passing through the first conduit. In a preferred embodiment, hollow fibers are used which serve as the back-pressure regulating feature, the adsorptive element, and the mixing chamber before being discharged at the outlet of the device.

A disc tube reverse osmosis module is provided. In various embodiments, deflector disc assemblies and associated membranes are sequentially alternately disposed from top to bottom. The upper flange is in sealing connection with the central pull rod, the upper lock nut is in threaded connection with an upper end of the central pull rod and located above the upper flange, the yielding water collecting pipe sleeves the central pull rod and is in sealing connection with a lower side of the lower flange, the lower lock nut is in threaded connection with a lower end of the central pull rod, an end of the yielding water receiving pipe is fixedly connected to the yielding water collecting pipe, an inner surface of the shell is respectively in sealing connection with the upper flange and the lower flange, and the water inlet receiving pipe and the concentrated liquid receiving pipe are fixed to the lower flange.