An electrodialysis desalination device includes a first electrode including a first-stage side; a second electrode including a first-stage side; and a first stage between the first-stage side of the first electrode and the first-stage side of the second electrode. The first stage includes at least one first-stage cell pair positioned between the first-stage side of the first electrode and the first-stage side of the second electrode, and each cell pair includes a pair of first-stage selectively permeable ion-exchange membranes with alternating selectivity that define first-stage channels on opposite sides of each first-stage membrane for respective flows of a first-stage diluate stream and a first-stage concentrate stream. A single pump is configured to pump the diluate streams and the concentrate streams through the first stage.

Methods of operating an electrochemical separation device is disclosed. The methods include operating the electrochemical separation device in an active mode until the resistance reaches a predetermined threshold, regenerating the electrochemical separation device in a passive mode until the resistance reaches a predetermined threshold, and resuming operation of the electrochemical separation device in the active mode. The methods also include operating the electrochemical separation device in an active mode for a predetermined period of time, regenerating the electrochemical separation device in a passive mode for a predetermined period of time, and resuming operation of the electrochemical separation device in the active mode. Water treatment systems include the electrochemical separation device and a control module are also disclosed. Methods of facilitating operation of the electrochemical separation device by providing a control sequence are also disclosed.