A small-scale, batch-wise device to simulate high-shear, short-duration emulsification of fluids from various industrial processes at elevated temperatures and pressures for the purpose of determining the quality and stability of those emulsions under different conditions and with different additives. A threaded, transparent tube capable high temperature and pressure is fitted with a threaded bearing with a shaft sealed gas tight at two points with spring-loaded, internally-facing, open rings. A socket head on the external end of the shaft held on a high-speed motor-drive rotates mixing blades on the internal end of the shaft. Process fluids and additives are added to the tube with a vaporizing liquid. The tube is sealed, heated to the process temperature under pressure, then inverted onto the motor drive, by which the blades are rotated at high-speed for a short duration. The tube is righted and the emulsion observed over time at process temperature under pressure.

Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

The present invention provides a method of efficiently manufacturing an emulsion that is improved in monodispersibility by a membrane emulsification method. The manufacturing method for an emulsion of the present invention includes circulating a mixed liquid containing a water phase and an oil phase in a circulation circuit including one or more tanks, a porous body, liquid-delivering means, and circulation pipes configured to connect the tanks, the porous body, and the liquid-delivering means so that the mixed liquid passes through the porous body a plurality of times, wherein the circulation circuit further includes a gas-separating device, and wherein the gas-separating device is configured to remove air bubbles from the mixed liquid therethrough.

The present invention provides a method of efficiently manufacturing an emulsion that is improved in monodispersibility by a membrane emulsification method. The manufacturing method for an emulsion of the present invention includes circulating a mixed liquid containing a water phase and an oil phase in a circulation circuit including one or more tanks, a porous body, liquid-delivering means, and circulation pipes configured to connect the tanks, the porous body, and the liquid-delivering means so that the mixed liquid passes through the porous body a plurality of times, wherein the circulation circuit further includes a gas-separating device, and wherein the gas-separating device is configured to remove air bubbles from the mixed liquid therethrough.

Methods and industrial scale set-ups for manufacturing spray-dried powders are provided. During the process, a solvent is used. The process is done batchwise such that the emulsification mass ratio is low when removal of the solvent is started. Preferred solvents are isopropyl acetate and ethyl acetate.

Methods and industrial scale set-ups for manufacturing spray-dried powders are provided. During the process, a solvent is used. The process is done batchwise such that the emulsification mass ratio is low when removal of the solvent is started. Preferred solvents are isopropyl acetate and ethyl acetate.

The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control, The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.

The present invention is generally related to systems and methods for producing droplets. The droplets may contain varying species, e.g., for use as a library. In some cases, at least one droplet is used to create a plurality of droplets, using techniques such as flow-focusing techniques. In one set of embodiments, a plurality of droplets, containing varying species, can be divided to form a collection of droplets containing the various species therein. A collection of droplets, according to certain embodiments, may contain various subpopulations of droplets that all contain the same species therein. Such a collection of droplets may be used as a library in some cases, or may be used for other purposes.

A flow-through cavitation device having an elongated housing with an inlet and an outlet. An inner annular body and an outer annular body are concentrically and nestingly disposed in the elongated housing. The outer annular body is fixed relative to the housing and the inner annular body is rotatable about a longitudinal axis of the housing. Each annular body has a plurality of channels that pass therethrough. Rotation of the inner body relative to the outer body provides for selective alignment or misalignment of the plurality of channels to control fluid flow from the inlet to the outlet. The device may have a plurality of pairs of inner and outer annular bodies as described.