An exemplary compounding system and method can include a transfer set that includes a manifold for assisting in transferring a plurality of ingredients from supply container(s) to a final container. The manifold can include a first channel in fluid communication with at least one primary ingredient, and a second channel in fluid communication with a plurality of secondary ingredients. The first channel and second channel can be in fluid isolation from each other such that the at least one primary ingredient does not mix with the plurality of secondary ingredients within the manifold. The transfer set can include a plurality of inlet lines in fluid communication with the manifold and two outlet lines configured for connection to two separate pumps and eventually being in fluid communication with the final container.

The present invention provides a method of efficiently manufacturing an emulsion that is improved in monodispersibility by a membrane emulsification method. The manufacturing method for an emulsion of the present invention includes circulating a mixed liquid containing a water phase and an oil phase in a circulation circuit including one or more tanks, a porous body, liquid-delivering means, and circulation pipes configured to connect the tanks, the porous body, and the liquid-delivering means so that the mixed liquid passes through the porous body a plurality of times, wherein the circulation circuit further includes a gas-separating device, and wherein the gas-separating device is configured to remove air bubbles from the mixed liquid therethrough.

A microfluidic system and method suitable for liquid mixing. The microfluidic system uses a pump (400) as the driving source, which draws at least two liquid samples that are to be mixed into the pump (400). Some air is drawn into the pump (400) as well. The system is also comprised of a mixing reservoir (203). The two liquids drawn into the pump (400) are pushed into the mixing reservoir (203). The air bubbles generated by the air have a stirring effect on the mixed liquid in the mixing reservoir (203). After the air bubbles burst, left at rest, and the air has risen to the top of the mixing reservoir (203), the mixed liquid is drawn back to the pump (400) and fed to the outlet (103) for subsequent detection steps. The addition of an antifoaming agent will prevent the accumulation of air bubbles during the mixing process. In the system, the valves (501, 502, 503, 504) and the sensors (601, 602, 603, 604) in the microfluidic channels (301, 302, 303, 304) will be used for the operation of the microfluidic system and for the precise control of the flow.

A microfluidic system and method suitable for liquid mixing. The microfluidic system uses a pump (400) as the driving source, which draws at least two liquid samples that are to be mixed into the pump (400). Some air is drawn into the pump (400) as well. The system is also comprised of a mixing reservoir (203). The two liquids drawn into the pump (400) are pushed into the mixing reservoir (203). The air bubbles generated by the air have a stirring effect on the mixed liquid in the mixing reservoir (203). After the air bubbles burst, left at rest, and the air has risen to the top of the mixing reservoir (203), the mixed liquid is drawn back to the pump (400) and fed to the outlet (103) for subsequent detection steps. The addition of an antifoaming agent will prevent the accumulation of air bubbles during the mixing process. In the system, the valves (501, 502, 503, 504) and the sensors (601, 602, 603, 604) in the microfluidic channels (301, 302, 303, 304) will be used for the operation of the microfluidic system and for the precise control of the flow.

A container with two inner chambers (6, 7) running in its longitudinal direction and separated by at least one partition wall. An aerobic adhesive is stored in one inner chamber (6). A hydrophilic, gel-like activator is stored in the other inner chamber (7); a mixing unit can be attached to the front end of the container. The aerobic adhesive is fed to the mixing unit from the first inner chamber (6), and the hydrophilic activator is fed to the mixing unit from the second inner chamber (7), in a specified mixing ratio via a supply device and mixed together there. This mixture is discharged via an outlet opening (13) of the mixing unit.

An exemplary compounding method of controlling a compounding device to prepare an admixture of at least two distinct material sources can include examining material source solutions for incompatibility of the ingredients and operating a first and a second pump to prevent one of the incompatible source solutions from entering a common flow path. The processing method can detect degradation of a fluid line by evaluating one or more of calibration error rate data, cumulative volumetric flow data, or cumulative pump operation data. The processing method can also selectively transfer a first group of source solutions using the first pump, receiving pump data from one or more sensors that sense actions of the pumps, applying fluid correction factors and calculating discrete pump movements, the pump movements being indicative of an amount of source solution displacement by a pump, and operating the pumps to selectively dispense the source solution amounts according to a preparation order.

An embodiment for a microfluidic device is provided. The device comprises two areas, arranged side-by-side, and a trigger channel. They include a first area, which is delimited by a first liquid pinning barrier, and a second area, which is delimited by a second liquid pinning barrier. The latter extends parallel to the first liquid pinning barrier to delimit a corridor. The trigger channel extends through the corridor between the two areas. In addition, the trigger channel connects the first liquid pinning barrier with the second liquid pinning barrier, allowing a first liquid pinned at the first liquid pinning barrier and a second liquid pinned at the second liquid pinning barrier to be contacted, each, by a reverse flow of the second liquid in the trigger channel and thereby start mixing at a level of the corridor, in operation. The invention is further directed to related methods of operation.

A delivery system is provided that includes a device having a body extending along a longitudinal axis between proximal and distal ends. The body includes a proximal chamber, a distal chamber and a wall between the chambers. The body includes a first port in communication with the proximal chamber and a second port in communication with the distal chamber. A shaft is movably positioned within the body. The shaft extends through the wall and includes a proximal plunger positioned within the proximal chamber and a distal plunger positioned within the distal chamber. Pressure introduced through an opening in the proximal end moves the shaft such that the proximal plunger moves a fluid within the proximal chamber out of the first port and the distal plunger moves a fluid within the distal chamber out of the second port to simultaneously actuate a bone filler dispenser. Systems and methods are also provided.

An apparatus for processing a substrate includes a mixing nozzle having a mixing space that is shaped as an inverted cone, the mixing nozzle including a first inlet, a second inlet and an outlet installed at the mixing space; a first chemical supply unit connected to the first inlet; a second chemical supply unit connected to the second inlet; and a supply tank connected to the outlet, wherein the first chemical supply unit is configured to supply a first chemical solution to the mixing space through the first inlet, the second chemical supply unit is configured to supply a second chemical solution to the mixing space through the second inlet, and the supply tank is supplied with, through the outlet, a solution mixture that is formed of the first chemical solution and the second chemical solution after being mixed in the mixing space.

A fluid mixer of the present invention has an element (1) and a chassis (2) that accommodates the element therein and that is engaged with at least both ends of the element, the element having: a first-flow-path forming section (13) at an end of which a fluid inlet (3) is formed and in which a first flow path (4) is formed; and a body section (12) at an end of which a fluid outlet (8) is formed, in which a second flow path (5) is formed, and on an outer circumferential surface of which a plurality of communicating holes (11) are formed so as to allow the second flow path to communicate with the outside. A plurality of delay members (9) are discontinuously formed in a flow-path axial direction on at least one of an inner circumferential surface of the chassis and the outer circumferential surface of the body section, a single continuous space is formed between the inner circumferential surface of the chassis and the outer circumferential surface of the body section, the space serves as a third flow path (6), and the communicating holes serve as branch flow paths (7).