Initial liquid containing fine bubbles is produced by mixing water and air (step S11). Fine bubbles have diameters of less than 1 m. The density of bubbles in the initial liquid is measured (step S13), and when the measured density is less than a target density (step S14), the initial liquid is heated and reduced in pressure so that the liquid is vaporized (step S15). As a volume of the liquid decreases, the density of fine bubbles increases, and high-density fine bubble-containing liquid is easily obtained. Alternatively, by increasing the density of fine bubbles in the initial liquid with using a filter that does not pass all fine bubbles, high-density fine bubble-containing liquid is easily acquired (step S15). When the density of bubbles in the initial liquid is greater than the target density, the initial liquid is diluted (step S16).

A device for mixing powders by a cryogenic fluid, characterised in that it comprises: a chamber for mixing the powders, comprising a cryogenic fluid, provided with means for forming a fluidised powder bed; a chamber for supplying powders in order to allow the powders to be introduced into the mixing chamber; a chamber for supplying cryogenic fluid in order to allow the cryogenic fluid to be introduced into the mixing chamber; a system for generating vibrations in the fluidised powder bed; and a system for controlling the system for generating vibrations.

Initial liquid containing fine bubbles is produced by mixing water and air (step S11). Fine bubbles have diameters of less than 1 m. The density of bubbles in the initial liquid is measured (step S13), and when the measured density is less than a target density (step S14), the initial liquid is heated and reduced in pressure so that the liquid is vaporized (step S15). As a volume of the liquid decreases, the density of fine bubbles increases, and high-density fine bubble-containing liquid is easily obtained. Alternatively, by increasing the density of fine bubbles in the initial liquid with using a filter that does not pass all fine bubbles, high-density fine bubble-containing liquid is easily acquired (step S15). When the density of bubbles in the initial liquid is greater than the target density, the initial liquid is diluted (step S16).

In order to eliminate liquid accumulation occurring between a gas-liquid mixing part and a vaporization part to stably perform liquid feeding to the vaporization part and vaporization in the vaporization part, a liquid material vaporization apparatus includes: a gas-liquid mixing part adapted to mix a liquid material and gas to produce a gas-liquid mixture; and a vaporization part adapted to heat the gas-liquid mixture to vaporize the liquid material. In addition, the gas-liquid mixing part has a gas-liquid mixture lead-out pipe for leading out the gas-liquid mixture, the vaporization part has a heating flow path HS for heating the gas-liquid mixture, and a lead-out port of the gas-liquid mixture lead-out pipe is arranged in the heating flow path HS.

The present invention is a liquid material vaporizing device that heats a liquid material supplying pipe without providing a heating mechanism, the liquid material vaporizing device including: a gas-liquid mixer unit configured to mix a liquid material and a gas to generate a gas-liquid mixture; a liquid material supplying pipe configured to supply the liquid material to the gas-liquid mixer unit; a vaporizer unit configured to heat the gas-liquid mixture to vaporize the liquid material; and a casing configured to house the gas-liquid mixer unit, the vaporizer unit, and the liquid material supplying pipe, in which a channel configured to guide convection of heat from the vaporizer unit to the liquid material supplying pipe is provided inside the casing.

The disclosure provides compositions comprising water and ultrafine bubbles, and optionally non-gaseous solutes. The disclosure also provides methods of making and using such compositions.

The current invention relates to a method for manufacturing one or more carriers with one or more active pharmaceutical ingredients, wherein said method comprises mixing at least a solution comprising one or more active pharmaceutical ingredients with one or more organic solvents comprising one or more lipids and/or polymers, thereby forming a formulation comprising one or more carriers, and subsequently removing at least part of said one or more organic solvents by a pervaporation step. In a second aspect, said invention also relates to a system for manufacturing such carriers, wherein said system comprises a pervaporation device for removal of one or more organic solvents from a formulation comprising one or more carriers.