Provided is a gas dissolving device capable of dissolving gas in a liquid in a supersaturated state and maintaining such a saturated state in a stable manner, and being easily attached to a water server or the like.

The gas dissolving device generates hydrogen water by dissolving hydrogen in water, and discharges the hydrogen water from an outlet. The gas dissolving device includes a dissolving chamber that stores under pressure generated hydrogen water introduced therein, and pressure reduction and transfer means for preventing pressure variation in a tube-shaped passage that connects the dissolving tank and the outlet due to an action of discharging the hydrogen water from the outlet, and for forming a laminar flow.

A coulter assembly for collecting soil samples from an agricultural field in one embodiment comprises an annular collection blade configured for penetrating soil to capture a sample, an annular cam ring configured for stationary mounting to a frame of an agricultural vehicle and comprising a cam track, a blade hub coupled to the blade for rotatably supporting the annular collection blade from the annular cam ring, and a movable sample collector mounted to the annular collection blade. The moveable sample collector is configured and operable for extracting a soil sample as the annular collection blade is rotated through the soil. The moveable sample collector in one embodiment comprises a piston mechanism including a cylinder and rod movably disposed therein which actuated by the annular cam ring to alternatingly open and close a collection end of the cylinder as the annular collection blade rotates through the soil.

Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.

Embodiments of the present application relate to compositions bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process with large particle diameter span.

The present invention relates to a device (60) for manufacturing pharmaceutical compositions, comprising: a support (62); a mixing container (16); a plurality of reservoirs (18, 20) containing starting materials for the composition of a medicament; at least one dispensing device (64, 66) that is designed to dispense an amount of a starting material into the mixing container, wherein the dispensing device is assembled, or is designed to be assembled, with a reservoir; a stirring device (68) that is able to stir the mixing container and/or the contents of the mixing container; and an electronic module (74) for controlling the at least one dispensing device.

The disclosure provides compositions comprising water and ultrafine bubbles, and optionally non-gaseous solutes. The disclosure also provides methods of making and using such compositions.

A composition of blending water for enhancing flavor of liquor. Provided is the composition of the blending water and the process for the preparation thereof wherein the blending water is prepared by purifying impurity and adding some natural extract and salts. Further provided is the preparation of concentrate comprising flavor enhancing agent and base thereof and the blending water use for blend and dilute the liquor.

The current invention relates to a method for manufacturing one or more carriers with one or more active pharmaceutical ingredients, wherein said method comprises mixing at least a solution comprising one or more active pharmaceutical ingredients with one or more organic solvents comprising one or more lipids and/or polymers, thereby forming a formulation comprising one or more carriers, and subsequently removing at least part of said one or more organic solvents by a pervaporation step. In a second aspect, said invention also relates to a system for manufacturing such carriers, wherein said system comprises a pervaporation device for removal of one or more organic solvents from a formulation comprising one or more carriers.

An automated bioprocess solution preparation apparatus includes a first mixing chamber containing at least one ingredient for a bioprocess solution, a first port and a second port for a fluid to enter the mixing chamber, and a third port for a liquid bioprocess solution to exit the mixing chamber. The apparatus further includes an array of tubing for fluid flow within the apparatus, a sensor arranged to measure a property of the liquid bioprocess solution exiting the mixing chamber, a first valve associated with the first port, and a second valve associated with the second port. When the property meets or exceeds a threshold value, the apparatus is operable to perform at least one of: closing the first valve to block the fluid from entering the mixing chamber through the first port, and opening the second valve for the fluid to enter the mixing chamber through the second port.

The present disclosure relates to systems and methods for producing nanoparticles of a material in a working liquid. The apparatus can include a core for accelerating the working liquid and the material, wherein the core includes: a first cylinder including: a radially outer surface and a radially inner surface; and a plurality of first through holes extending from the radially inner surface to the radially outer surface of the first cylinder; a second cylinder including: a radially outer surface and a radially inner surface; and a plurality of second through holes extending from the radially inner surface to the radially outer surface of the second cylinder; wherein the second cylinder radially surrounds the first cylinder; wherein each of the first through holes and the second through holes have a smaller cross-section at the radially inner surface than at the radially outer surface.